Post-ischemic cyclooxygenase-2 expression is regulated by the extent of cerebral blood flow reduction in non-human primates

Neuroscience Letters

Volumn 341, Issue 1, 2003, Pages 37-40

  Yokota, Chiaki ^a   Kuge, Yuji ^b,c   Inoue, Hiroyasu ^a   Tagaya, Masafumi ^d   Kito, Go ^e   Susumu, Teruo ^e   Tamaki, Nagara ^b   Minematsu, Kazuo ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Inst Biofunctional Res Co Inc   (Japan)

^d Osaka Hospital   (Japan)

^e SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

Cerebral blood flow; Cerebral glucose metabolic rate; Cyclooxygenase 2; Focal brain ischemia; Positron emission tomography; Primate

Indexed keywords

CYCLOOXYGENASE 2; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE INDUCTION; GLUCOSE METABOLISM; MALE; METABOLIC RATE; NONHUMAN; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIMATE; PRIORITY JOURNAL; RANDOMIZATION; TEMPORAL LOBE; UPREGULATION;

EID: 0037464401     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00152-6     Document Type: Article

References (13)

1. Collaco-Moraes Y., Aspey B., Harrison M., Belleroche J.D. Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;1366-1372.
2. Heiss W.-D., Graf R., Wienhard K., Saito L.R., Fujita T., Rosner G., Wagner R. Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J. Cereb. Blood Flow Metab. 14:1994;892-902.
3. Iadecola C., Forster C., Nogawa S., Clark H.B., Ross M.E. Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. Acta. Neuropathol. 98:1999;9-14.
4. Iadecola C., Niwa K., Nogawa S., Zhao X., Nagayama M., Araki E., Morham S., Ross M.E. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc. Natl. Acad. Sci. USA. 98:2001;1294-1299.
5. Inoue H., Tanabe T., Umesono K. Feedback control of cyclooxygenase-2 expression through PPARgammma. J. Biol. Chem. 275:2000;28028-28032.
6. Inoue H., Yokoyama C., Hara S., Tone Y., Tanabe T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. J. Biol. Chem. 270:1995;24965-24971.
7. Kito G., Nishimura A., Susumu T., Nagata R., Kuge Y., Yokota C., Minematstu K. Experimental thromboembolic stroke in cynomolgus monkey. J. Neurosci. Methods. 105:2001;45-53.
8. Kuge Y., Yokota C., Tagaya M., Hasegawa Y., Nishimura A., Kito G., Tamaki N., Hashimoto N., Yamaguchi T., Minematsu K. Serial changes in cerebral blood flow and flow-metabolism uncoupling in primates with acute thromboembolic stroke. J. Cereb. Blood Flow Metab. 21:2001;202-210.
9. Miettinen S., Fusco F.R., Yrjanheikki J., Keinanen R., Hirvonen T., Roivainen R., Narhi M., Hokfelt T., Koistinaho J. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. Proc. Natl. Acad. Sci. USA. 94:1997;6500-6505.
10. Nogawa S., Zhang F., Ross M.E., Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 17:1997;2746-2755.
11. Sairanen T., Ristimaki A., Karjalainen-Lindsberg M.-L., Paetau A., Kaste M., Lindsberg P.J. Cyclooxygenase-2 induced globally in infarcted human brain. Ann. Neurol. 43:1998;738-747.
12. Wienhard K., Dahlbom M., Eriksson L., Michel C., Bruckbauer T., Pietrzyk U., Heiss W.D. The ECAT EXACT HR: performance of a new high resolution positron scanner. J. Comput. Assist. Tomogr. 18:1994;110-118.
13. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 11:1993;371-386.