Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity

Journal of Organic Chemistry

Volumn 68, Issue 6, 2003, Pages 2350-2361

  Su, Bao Ning ^a   Park, Eun Jung ^a   Nikolic, Dejan ^a   Santarsiero, Bernard D ^a   Mesecar, Andrew D ^a   Vigo, Jose Schunke ^b   Graham, James G ^a   Cabieses, Fernando ^b   Van Breemen, Richard B ^a   Fong, Harry H S ^a   Farnsworth, Norman R ^a   Pezzuto, John M ^a   Kinghorn, A Douglas ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Instituto Nacional de Medicina Tradicional INMETRA   (Peru)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CELLS; PURIFICATION; SINGLE CRYSTALS; X RAY DIFFRACTION ANALYSIS;

CHEMOPREVENTIVE ACTIVITY;

ONCOLOGY;

DEPREA SUBTRIFLORA EXTRACT; NORWITHANOLIDE; PLANT EXTRACT; SUBTRIFLORALACTONE A; SUBTRIFLORALACTONE B; SUBTRIFLORALACTONE C; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG ISOLATION; ENZYME ACTIVITY; INGESTION; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOMA, HEPATOCELLULAR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; LACTONES; MICE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PERU; PLANTS, MEDICINAL; SOLANACEAE; TUMOR CELLS, CULTURED;

EID: 0037459704     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020542u     Document Type: Article

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