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Volumn 41, Issue 4 SUPPL. 4, 2003, Pages S70-S78

The evolving role of direct thrombin inhibitors in acute coronary syndromes

Author keywords

[No Author keywords available]

Indexed keywords

ARGATROBAN; EFEGATRAN; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; HIRUDIN; HIRULOG; INOGATRAN; THROMBIN INHIBITOR;

EID: 0037454047     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0735-1097(02)02687-6     Document Type: Review
Times cited : (37)

References (59)
  • 1
    • 0027125530 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes
    • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:242-50.
    • (1992) N Engl J Med , vol.326 , pp. 242-250
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 2
    • 0027125530 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes
    • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:310-8.
    • (1992) N Engl J Med , vol.326 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 3
    • 0027123107 scopus 로고
    • Molecular and cellular biology of blood coagulation
    • Furie B, Furie BC. Molecular and cellular biology of blood coagulation. N Engl J Med 1992;326:800-6.
    • (1992) N Engl J Med , vol.326 , pp. 800-806
    • Furie, B.1    Furie, B.C.2
  • 4
    • 0033599835 scopus 로고    scopus 로고
    • New antithrombotic agents
    • Hirsh J, Weitz JI. New antithrombotic agents. Lancet 1999;353:1431-6.
    • (1999) Lancet , vol.353 , pp. 1431-1436
    • Hirsh, J.1    Weitz, J.I.2
  • 5
    • 0034600424 scopus 로고    scopus 로고
    • Unfractionated heparin and low-molecular-weight heparin in acute coronary syndrome without ST elevation: A meta-analysis
    • Eikelboom JW, Anand SS, Malmberg K, Weitz JI, Ginsberg JS, Yusuf S. Unfractionated heparin and low-molecular-weight heparin in acute coronary syndrome without ST elevation: a meta-analysis. Lancet 2000;355:1936-42.
    • (2000) Lancet , vol.355 , pp. 1936-1942
    • Eikelboom, J.W.1    Anand, S.S.2    Malmberg, K.3    Weitz, J.I.4    Ginsberg, J.S.5    Yusuf, S.6
  • 6
    • 0025146426 scopus 로고
    • Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors
    • Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest 1990;86:385-91.
    • (1990) J Clin Invest , vol.86 , pp. 385-391
    • Weitz, J.I.1    Hudoba, M.2    Massel, D.3    Maraganore, J.4    Hirsh, J.5
  • 7
    • 0031936090 scopus 로고    scopus 로고
    • Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors
    • Weitz JI, Leslie B, Hudoba M. Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors. Circulation 1998;97:544-52.
    • (1998) Circulation , vol.97 , pp. 544-552
    • Weitz, J.I.1    Leslie, B.2    Hudoba, M.3
  • 8
    • 0030755896 scopus 로고    scopus 로고
    • Direct thrombin inhibitors: Appraisal of the antithrombotic/hemorrhagic balance
    • Verstraete M. Direct thrombin inhibitors: appraisal of the antithrombotic/hemorrhagic balance. Thromb Haemost 1997;78:357-63.
    • (1997) Thromb Haemost , vol.78 , pp. 357-363
    • Verstraete, M.1
  • 9
    • 0024582671 scopus 로고
    • Effects of thrombin inhibition on development of acute platelet-thrombus deposition during angioplasty in pigs
    • Heras M, Chesebro JH, Penny WS, Bailey KR, Badimon L, Fuster V. Effects of thrombin inhibition on development of acute platelet-thrombus deposition during angioplasty in pigs. Circulation 1989;79:657-65.
    • (1989) Circulation , vol.79 , pp. 657-665
    • Heras, M.1    Chesebro, J.H.2    Penny, W.S.3    Bailey, K.R.4    Badimon, L.5    Fuster, V.6
  • 10
    • 0025824011 scopus 로고
    • Thrombin regulation of platelet interaction with damaged vessel wall and isolated collagen type I at arterial flow conditions in a porcine model: Effects of hirudins, heparin, and calcium chelation
    • Badimon L, Badimon JJ, Lassila R, Heras M, Chesebro JH, Fuster V. Thrombin regulation of platelet interaction with damaged vessel wall and isolated collagen type I at arterial flow conditions in a porcine model: effects of hirudins, heparin, and calcium chelation. Blood 1991;78:423-34.
    • (1991) Blood , vol.78 , pp. 423-434
    • Badimon, L.1    Badimon, J.J.2    Lassila, R.3    Heras, M.4    Chesebro, J.H.5    Fuster, V.6
  • 11
    • 34548144432 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in acute coronary syndromes and during percutaneous coronary intervention: Design of a meta-analysis based on individual patient data
    • Direct Thrombin Inhibitor Trialists' Collaborative Group. Direct thrombin inhibitors in acute coronary syndromes and during percutaneous coronary intervention: design of a meta-analysis based on individual patient data. Am Heart J 2001;141:E2-6.
    • (2001) Am Heart J , vol.141
  • 12
    • 0025817404 scopus 로고
    • Past, present and future of hirudin
    • Markwardt F. Past, present and future of hirudin. Haemostasis 1991;21:11-26.
    • (1991) Haemostasis , vol.21 , pp. 11-26
    • Markwardt, F.1
  • 13
    • 0030015015 scopus 로고    scopus 로고
    • Hirudins: From leeches to man
    • Wallis RB. Hirudins: from leeches to man. Semin Thromb Hemost 1996;22:185-96.
    • (1996) Semin Thromb Hemost , vol.22 , pp. 185-196
    • Wallis, R.B.1
  • 14
    • 0025346345 scopus 로고
    • Design and characterisation of hirulogs: A novel class of bivalent peptide inhibitors of thrombin
    • Maraganore JM, Bourdon P, Jablonski J, Ramachandran KL, Fenton JW. Design and characterisation of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. Biochemistry 1990;29:7095-101.
    • (1990) Biochemistry , vol.29 , pp. 7095-7101
    • Maraganore, J.M.1    Bourdon, P.2    Jablonski, J.3    Ramachandran, K.L.4    Fenton, J.W.5
  • 15
    • 0031729548 scopus 로고    scopus 로고
    • Direct thrombin inhibitors for treatment of arterial thrombosis: Potential differences between bivalirudin and hirudin
    • Bates SM, Weitz JI. Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin. Am J Cardiol 1998;82:12P-8P.
    • (1998) Am J Cardiol , vol.82
    • Bates, S.M.1    Weitz, J.I.2
  • 18
    • 0030222368 scopus 로고    scopus 로고
    • Antithrombotic activity of inogatran, a new low-molecular-weight inhibitor of thrombin, in a closed chest porcine model of coronary artery thrombosis
    • Uriuda Y, Wang QD, Grip L, Ryden L, Sjoquist PO, Mattsson C. Antithrombotic activity of inogatran, a new low-molecular-weight inhibitor of thrombin, in a closed chest porcine model of coronary artery thrombosis. Cardiovasc Res 1996;32:320-7.
    • (1996) Cardiovasc Res , vol.32 , pp. 320-327
    • Uriuda, Y.1    Wang, Q.D.2    Grip, L.3    Ryden, L.4    Sjoquist, P.O.5    Mattsson, C.6
  • 19
    • 0027959329 scopus 로고
    • Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: Comparison with heparin and recombinant hirudin
    • Berry CN, Girardot C, Lecoffre C, Lunven C. Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: comparison with heparin and recombinant hirudin. Thromb Haemost 1994;72:381-6.
    • (1994) Thromb Haemost , vol.72 , pp. 381-386
    • Berry, C.N.1    Girardot, C.2    Lecoffre, C.3    Lunven, C.4
  • 20
    • 0027361488 scopus 로고
    • Recombinant hirudin in patients with chronic stable coronary artery disease: Safety, half-life and effect on coagulation parameters
    • Zoldhelyi P, Webster MWI, Fuster V, et al. Recombinant hirudin in patients with chronic stable coronary artery disease: safety, half-life and effect on coagulation parameters. Circulation 1993;88:2015-22.
    • (1993) Circulation , vol.88 , pp. 2015-2022
    • Zoldhelyi, P.1    Webster, M.W.I.2    Fuster, V.3
  • 21
    • 0029153842 scopus 로고
    • r-Hirudin in unstable angina pectoris: Rationale and preliminary data from the APT pilot study
    • Fox KA. r-Hirudin in unstable angina pectoris: rationale and preliminary data from the APT pilot study. Eur Heart J 1995;16:28-32.
    • (1995) Eur Heart J , vol.16 , pp. 28-32
    • Fox, K.A.1
  • 22
    • 0029153048 scopus 로고
    • Recombinant hirudin and front-loaded alteplase in acute myocardial infarction: Final results of a pilot study: HIT-I (Hirudin for the Improvement of Thrombolysis)
    • Zeymer U, von Essen R, Tebbe U, et al. Recombinant hirudin and front-loaded alteplase in acute myocardial infarction: final results of a pilot study: HIT-I (Hirudin for the Improvement of Thrombolysis). Eur Heart J 1995;16:22-7.
    • (1995) Eur Heart J , vol.16 , pp. 22-27
    • Zeymer, U.1    Von Essen, R.2    Tebbe, U.3
  • 23
    • 15444340960 scopus 로고    scopus 로고
    • HBW 023 (recombinant hirudin) for the acceleration of thrombolysis and prevention of coronary reocclusion in acute myocardial infarction: Results of a dose-finding study (HIT-II) by the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte
    • von Essen R, Zeymer U, Tebbe U, et al. HBW 023 (recombinant hirudin) for the acceleration of thrombolysis and prevention of coronary reocclusion in acute myocardial infarction: results of a dose-finding study (HIT-II) by the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte. Coron Artery Dis 1998;9:265-72.
    • (1998) Coron Artery Dis , vol.9 , pp. 265-272
    • Von Essen, R.1    Zeymer, U.2    Tebbe, U.3
  • 24
    • 0028346249 scopus 로고
    • Recombinant hirudin for unstable angina pectoris: A multicenter, randomized angiographic trial
    • Topol EJ, Fuster V, Harrington RA, et al. Recombinant hirudin for unstable angina pectoris: a multicenter, randomized angiographic trial. Circulation 1994;89:1557-66.
    • (1994) Circulation , vol.89 , pp. 1557-1566
    • Topol, E.J.1    Fuster, V.2    Harrington, R.A.3
  • 25
    • 0029084036 scopus 로고
    • Angiographic dose-finding study with r-hirudin (HBW 023) for the improvement of thrombolytic therapy with streptokinase (HIT-SK): Interim results
    • Molhoek GP, Laarman GJ, Lok DJ, et al. Angiographic dose-finding study with r-hirudin (HBW 023) for the improvement of thrombolytic therapy with streptokinase (HIT-SK): interim results. Eur Heart J 1995;16:33-7.
    • (1995) Eur Heart J , vol.16 , pp. 33-37
    • Molhoek, G.P.1    Laarman, G.J.2    Lok, D.J.3
  • 26
    • 0028296374 scopus 로고
    • A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis In Myocardial Infarction (TIMI) 5 trial
    • Cannon CP, McCabe CH, Henry TD, et al. A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis In Myocardial Infarction (TIMI) 5 trial. J Am Coll Cardiol 1994;23:993-1003.
    • (1994) J Am Coll Cardiol , vol.23 , pp. 993-1003
    • Cannon, C.P.1    McCabe, C.H.2    Henry, T.D.3
  • 27
    • 0028795568 scopus 로고
    • Initial experience with hirudin and streptokinase in acute myocardial infarction: Results of the Thrombolysis In Myocardial Infarction (TIMI) 6 trial
    • Lee LV. Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis In Myocardial Infarction (TIMI) 6 trial. Am J Cardiol 1995;75:7-13.
    • (1995) Am J Cardiol , vol.75 , pp. 7-13
    • Lee, L.V.1
  • 28
    • 0033213674 scopus 로고    scopus 로고
    • Recombinant hirudin (Lepirudin) for the improvement of thrombolysis with streptokinase in patients with acute myocardial infarction: Results of the HIT-4 trial
    • Neuhaus KL, Molhoek GP, Zeymer U, et al. Recombinant hirudin (Lepirudin) for the improvement of thrombolysis with streptokinase in patients with acute myocardial infarction: results of the HIT-4 trial. J Am Coll Cardiol 1999;34:966-73.
    • (1999) J Am Coll Cardiol , vol.34 , pp. 966-973
    • Neuhaus, K.L.1    Molhoek, G.P.2    Zeymer, U.3
  • 29
    • 0343580449 scopus 로고    scopus 로고
    • Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: A pilot study
    • Organisation to Assess Strategies for Ischemic Syndromes (OASIS) Investigators. Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: a pilot study. Circulation 1997;96:769-77.
    • (1997) Circulation , vol.96 , pp. 769-777
  • 30
    • 0028037517 scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994;90:1631-7.
    • (1994) Circulation , vol.90 , pp. 1631-1637
  • 31
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction: Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial
    • Antman EM. Hirudin in acute myocardial infarction: safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial. Circulation 1994;90:1624-30.
    • (1994) Circulation , vol.90 , pp. 1624-1630
    • Antman, E.M.1
  • 32
    • 0028117846 scopus 로고
    • Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study: A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte
    • Neuhaus KL, von Essen R, Tebbe U, et al. Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study: a study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte. Circulation 1994;90:1638-42.
    • (1994) Circulation , vol.90 , pp. 1638-1642
    • Neuhaus, K.L.1    Von Essen, R.2    Tebbe, U.3
  • 33
    • 0029835392 scopus 로고    scopus 로고
    • A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
    • The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996;335:775-82.
    • (1996) N Engl J Med , vol.335 , pp. 775-782
  • 34
    • 0029788104 scopus 로고    scopus 로고
    • Hirudin in acute myocardial infarction: Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial
    • Antman EM. Hirudin in acute myocardial infarction: Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation 1996;94:911-21.
    • (1996) Circulation , vol.94 , pp. 911-921
    • Antman, E.M.1
  • 35
    • 0033528281 scopus 로고    scopus 로고
    • Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: A randomised trial
    • Organisation to Assess Strategies for Ischemic Syndromes (OASIS-2) Investigators. Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial. Lancet 1999;353:429-38.
    • (1999) Lancet , vol.353 , pp. 429-438
  • 36
    • 0027140468 scopus 로고
    • Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris
    • Sharma GV, Lapsley D, Vita JA, et al. Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris. Am J Cardiol 1993;72:1357-60.
    • (1993) Am J Cardiol , vol.72 , pp. 1357-1360
    • Sharma, G.V.1    Lapsley, D.2    Vita, J.A.3
  • 37
    • 0027497137 scopus 로고
    • Initial experience with a direct antithrombin, hirulog, in unstable angina: Anticoagulant, antithrombotic, and clinical effects
    • Lidon RM, Theroux P, Juneau M, Adelman B, Maraganore J. Initial experience with a direct antithrombin, hirulog, in unstable angina: anticoagulant, antithrombotic, and clinical effects. Circulation 1993;88:1495-501.
    • (1993) Circulation , vol.88 , pp. 1495-1501
    • Lidon, R.M.1    Theroux, P.2    Juneau, M.3    Adelman, B.4    Maraganore, J.5
  • 38
    • 0029148676 scopus 로고
    • Hirulog in the treatment of unstable angina: Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial
    • Fuchs J, Cannon CPA. Hirulog in the treatment of unstable angina: results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial. Circulation 1995;92:727-33.
    • (1995) Circulation , vol.92 , pp. 727-733
    • Fuchs, J.1    Cannon, C.P.A.2
  • 39
    • 0028936602 scopus 로고
    • Randomized double-blind comparison of two doses of hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction
    • Theroux P, Perez-Villa F, Waters D, Lesperance J, Shabani F, Bonan R. Randomized double-blind comparison of two doses of hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction. Circulation 1995;91:2132-9.
    • (1995) Circulation , vol.91 , pp. 2132-2139
    • Theroux, P.1    Perez-Villa, F.2    Waters, D.3    Lesperance, J.4    Shabani, F.5    Bonan, R.6
  • 40
    • 0030771823 scopus 로고    scopus 로고
    • Randomized, double-blind comparison of hirulog versus heparin in patients receiving streptokinase and aspirin for acute myocardial infarction (HERO)
    • White HD, Aylward PE, Frey MJ, et al. Randomized, double-blind comparison of hirulog versus heparin in patients receiving streptokinase and aspirin for acute myocardial infarction (HERO). Circulation 1997;96:2155-61.
    • (1997) Circulation , vol.96 , pp. 2155-2161
    • White, H.D.1    Aylward, P.E.2    Frey, M.J.3
  • 41
    • 0032738541 scopus 로고    scopus 로고
    • Clinical outcomes of bivalirudin for ischemic heart disease
    • Kong DF, Topol EJ, Bittl JA, et al. Clinical outcomes of bivalirudin for ischemic heart disease. Circulation 1999;100:2049-53.
    • (1999) Circulation , vol.100 , pp. 2049-2053
    • Kong, D.F.1    Topol, E.J.2    Bittl, J.A.3
  • 42
    • 0029103184 scopus 로고
    • Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina: Hirulog Angioplasty study investigators
    • Bittl JA, Strony J, Brinker JA, et al. Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina: Hirulog Angioplasty study investigators. N Engl J Med 1995;333:764-9.
    • (1995) N Engl J Med , vol.333 , pp. 764-769
    • Bittl, J.A.1    Strony, J.2    Brinker, J.A.3
  • 43
    • 0035206428 scopus 로고    scopus 로고
    • Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty study
    • Bittl JA, Chaitman BR, Feit F, et al. Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: final report reanalysis of the Bivalirudin Angioplasty study. Am Heart J 2001;142:952-9.
    • (2001) Am Heart J , vol.142 , pp. 952-959
    • Bittl, J.A.1    Chaitman, B.R.2    Feit, F.3
  • 44
    • 0035206572 scopus 로고    scopus 로고
    • A second look at bivalirudin
    • Antmann E, Braunwald E. A second look at bivalirudin. Am Heart J 2001;142:929-31.
    • (2001) Am Heart J , vol.142 , pp. 929-931
    • Antmann, E.1    Braunwald, E.2
  • 45
    • 0035651983 scopus 로고    scopus 로고
    • Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: The HERO-2 randomised trial
    • White HD, on behalf of the Hirulog and Early Reperfusion or Occlusion (HERO) Study Group. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet 2001;358:1855-63.
    • (2001) Lancet , vol.358 , pp. 1855-1863
    • White, H.D.1
  • 46
    • 0032694598 scopus 로고    scopus 로고
    • A multicentre, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: Myocardial infarction with novastan and TPA (MINT) study
    • Jang I-K, Brown DF, Giugliano RP, et al. A multicentre, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol 1999;33:1879-85.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1879-1885
    • Jang, I.-K.1    Brown, D.F.2    Giugliano, R.P.3
  • 47
    • 0001873571 scopus 로고    scopus 로고
    • Direct antithrombin-argatroban in acute myocardial infarction (ARGAMI-2) in late breaking clinical trials
    • Kaplinsky E. Direct antithrombin-argatroban in acute myocardial infarction (ARGAMI-2) in late breaking clinical trials. J Am Coll Cardiol 1998;32:1-7.
    • (1998) J Am Coll Cardiol , vol.32 , pp. 1-7
    • Kaplinsky, E.1
  • 48
    • 0033179314 scopus 로고    scopus 로고
    • Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina
    • Klootwijk P, Lenderink T, Meij S, et al. Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina. Eur Heart J 1999;20:1101-11.
    • (1999) Eur Heart J , vol.20 , pp. 1101-1111
    • Klootwijk, P.1    Lenderink, T.2    Meij, S.3
  • 49
    • 0030762734 scopus 로고    scopus 로고
    • A low molecular weight, selective thrombin inhibitor, inogatran, vs heparin in unstable coronary artery disease in 1209 patients: A double-blindrandomized dose-finding study
    • Thrombin Inhibition in Myocardial Ischaemia (TRIM) study group
    • The TRIM Investigators. A low molecular weight, selective thrombin inhibitor, inogatran, vs heparin in unstable coronary artery disease in 1209 patients: a double-blindrandomized dose-finding study. Thrombin Inhibition in Myocardial Ischaemia (TRIM) study group. Eur Heart J 1997;18:1416-25.
    • (1997) Eur Heart J , vol.18 , pp. 1416-1425
  • 50
    • 0037176525 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in acute coronary syndromes: A meta-analysis based on individual patient data
    • Direct Thrombin Inhibitor Trialists' Collaborative Group. Direct thrombin inhibitors in acute coronary syndromes: a meta-analysis based on individual patient data. Lancet 2002;359:294-302.
    • (2002) Lancet , vol.359 , pp. 294-302
  • 51
    • 0031729548 scopus 로고    scopus 로고
    • Direct thrombin inhibitors for treatment of arterial thrombosis: Potential differences between bivalirudin and hirudin
    • Bates SM, Weitz JI. Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin. Am J Cardiol 1998;82:12P-8P.
    • (1998) Am J Cardiol , vol.82
    • Bates, S.M.1    Weitz, J.I.2
  • 52
    • 12244281403 scopus 로고    scopus 로고
    • Early percutaneous coronary intervention in hirudin and unfractionated heparin-treated patients with acute coronary syndromes
    • Mehta S, Eikelboom JW, Natarajan M, et al. Early percutaneous coronary intervention in hirudin and unfractionated heparin-treated patients with acute coronary syndromes. Eur Heart J 2002;23:17-23.
    • (2002) Eur Heart J , vol.23 , pp. 17-23
    • Mehta, S.1    Eikelboom, J.W.2    Natarajan, M.3
  • 53
    • 0037132843 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A meta-analysis of all major randomised clinical trials
    • Boersma E, Harrington RA, Moliterno D, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet 2002;359:189-98.
    • (2002) Lancet , vol.359 , pp. 189-198
    • Boersma, E.1    Harrington, R.A.2    Moliterno, D.3
  • 54
    • 0029944889 scopus 로고    scopus 로고
    • Modulating platelet function with direct thrombin inhibitors
    • Verstraete M. Modulating platelet function with direct thrombin inhibitors. Haemostasis 1996;26:70-7.
    • (1996) Haemostasis , vol.26 , pp. 70-77
    • Verstraete, M.1
  • 56
    • 2242477091 scopus 로고
    • Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty
    • The EPIC Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994;330:956-61.
    • (1994) N Engl J Med , vol.330 , pp. 956-961
  • 57
    • 0029101260 scopus 로고
    • A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty: HELVETICA investigators
    • Serruys PW, Herrmann JP, Simon R, et al. A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty: HELVETICA investigators. N Engl J Med 1995;333:757-63.
    • (1995) N Engl J Med , vol.333 , pp. 757-763
    • Serruys, P.W.1    Herrmann, J.P.2    Simon, R.3
  • 58
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST elevation
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK, on behalf of the Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST elevation. N Engl J Med 2001;345:494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 59
    • 0035949117 scopus 로고    scopus 로고
    • Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction
    • The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet 2001;358:605-13.
    • (2001) Lancet , vol.358 , pp. 605-613


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