Midazolam nasal spray for patients with epilepsy. The plasma concentrations are fine; now the value in practice;Midazolamneusspray bij patiënten met epilepsie: De spiegels zijn goed; nu nog de waarde in de praktijk

Pharmaceutisch Weekblad

Volumn 138, Issue 3, 2003, Pages 99-103

  Tenk, H ^a   Jonker, D M ^a   Van der Hoeven, R T M ^a   Vermeij, T A C ^a   Edelbroek, P M ^a   De Haan, G J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYMIDAZOLAM; CARBAMAZEPINE; DRUG METABOLITE; GABAPENTIN; LAMOTRIGINE; MIDAZOLAM; NOSE SPRAY; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADULT; ANTICONVULSANT THERAPY; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG EFFECT; DRUG HALF LIFE; EPILEPSY; FEMALE; HUMAN; MALE;

EID: 0037449578     PISSN: 00316911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Hanley DF, Kross JF. Use of midazolam in the treatment of refractory status epilepticus. Clin Ther 1998;20:1093-105.
2. Scott RC, Besag FMC, Boyd SG, et al. Buccal absorption of midazolam: pharmacokinetics and EEG pharmacodynamics. Epilepsia 1998;39:290-4.
3. Malinovsky JM, Populaire C, Cozian A, et al. Premedication with midazolam in children. Effect of intranasal, rectal and oral routes on plasma midazolam concentrations. Anaesthesia 1995;50:351-4.
4. Björkman S, Rigemar G, Idvall J. Pharmacokinetics of midazolam given as an intranasal spray to adult surgical patients. Br J Anaest 1997;79:575-80.
5. Lahat E, Goldman M, Barr J, et al. Comparision of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. BMJ 2000;321(7253):83-6.
6. Fisgin T, Gurer Y, Senbil N, et al. Nasal midazolam effects on childhood acute seizures. J Child Neurol 2000;(12):833-5.
7. Fisgin T, Gurer Y, Tezic T, et al. Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study. J Child Neurol 2002;17(2):123-6.
8. Walbergh EJ, Wills RJ, Eckhert J. Plasma concentrations of midazolam in children following intranasal administration. Anesthesiology 1991;74(2):233-5.
9. Burstein AH, Modica R, Hatton M, et al. Pharmacokinetics and pharmacodynamics of midazolam after intranasal administration. J Clin Pharmacol 1997;37(8):711-8.
10. Knoester PD, Jonker DM, Van der Hoeven RTM, et al. Midazolam intranasaal toegepast, eventueel als noodmedicatie. Pharm Weekbl 2002;137:112-7.
11. Knoester PD, Jonker DM, Van der Hoeven RTM, et al. Pharmcokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers. Br J Clin Pharmacol 2002;53:501-7.
12. Dingemanse J, Van Gerven JMA, Schoemaker RC. et al. Integrated pharmacokinetics and pharmacodynamics of Ro 48-6791, a new benzodiazepine, in comparision with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol 1997;44:477-86.