The binding of CpG-oligodeoxynucleotides to cell-surface and its immunostimulatory activity are modulated by extracellular acidic pH

Vaccine

Volumn 21, Issue 5-6, 2003, Pages 485-490

  Hu, Zhenlin ^a   Sun, Shuhan ^a   Zhou, Fengjuan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Binding; Cell surface; CpG oligodeoxynucleotides; Immunostimulation

Indexed keywords

DNA; OLIGODEOXYNUCLEOTIDE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CPG ISLAND; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BINDING SITES; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EXTRACELLULAR SPACE; FISHES; HUMANS; HYDROGEN-ION CONCENTRATION; ISOTOPE LABELING; LYMPHOCYTES; MALE; MICE; MICE, INBRED ICR; OLIGONUCLEOTIDES; PHOSPHORUS RADIOISOTOPES; RECEPTORS, CELL SURFACE; SPERMATOZOA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037449525     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00477-2     Document Type: Article

References (22)

1. Kreig A.M., Hartmann G., Yi A.K. Mechanism of action of CpG DNA. Curr. Top. Microbiol. Immunol. 247:2000;1.
2. Davis H.L. Use of CpG DNA for enhancing specific immune responses. Curr. Top. Microbiol. Immunol. 247:2000;170.
3. Kline J.N. Effects of CpG DNA on Th1/Th2 balance in asthma. Curr. Top. Microbiol. Immunol. 247:2000;210.
4. Liang H., Nishioka Y., Reich C.F., Pisetsky D.S., Lipsky P.E. Activation of human B cells by phosphorothioate oligodeoxynucleotides. J. Clin. Invest. 98:1996;1119.
5. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H.et al. A toll-like receptor recognizes bacterial DNA. Nature. 408:2000;740.
6. Manzel L., Macfarlane D.E. Lack of immune stimulation by immobilized CpG-oligodeoxynucleotide. Antisense Nucl. Acid Drug Dev. 9:1999;459.
7. Bennett R.M., Gabor G.T., Merritt M.M. DNA binding to human leukocytes evidence for a receptor-mediated association, internalization, and degradation of DNA. J. Clin. Invest. 76:1985;2182.
8. Tonkinson J.L., Stein C.A. Patterns of intracellular acompartmentation. Nucleic Acid Res. 22:1994;4268.
9. Yi A.K., Tuetken R., Redford T., Waldschmidt M., Kirsch J., Krieg A.M. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160:1998;4755.
10. Hacker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T.et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:1998;6230.
11. Yi A.K., Linman D.M., Martin T.L., Krieg A.M. Rapid immune activation by CpG motifs in bacterial DNA: systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol. 157:1996;5394.
12. Hartmann G.A., Krug A., Eigler A., Moeller J., Murphy J., Albrecht R.et al. Specific suppression of human tumor necrosis factor-α synthesis by antisense oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev. 6:1999;291.
13. Kimura Y., Sonehara K., Kuramoto E., Makino T., Yamamoto S., Yamamoto T.et al. Binding of oligoguanylate to scavenger receptor is required for oligonucleotides to augment NK cell activity and induce IFN. J. Biochem. 116:1994;991.
14. Benimetskaya L., Loike J.D., Khaled Z., Loike G., Silverstein S.C., Cao L. Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein. Nat. Med. 3:1997;414.
15. Rykova E.Y., Laktionov P.P., Vlassov V.V.et al. Activation of spleen lymphocytes by plasmid DNA. Vaccine. 17:1999;1193.
16. Hu Z.L., Sun S.H., Dai J.X., Zhou F.J. Immunostimulatory sequence up-modulate the interaction between immunoglobulins and plasmid DNA at acidic pH. Vaccine. 19:2001;3051.
17. Bauer S., Kirschning C.J., Hacker H., Redecke V., Hausmann S., Akira S.et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9237.
18. Fujita N., Shimotake N., Ohki I., Chiba T., Saya H., Shirakawa M.et al. Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Mol. Cell. Biol. 20:2000;5107.
19. Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M.et al. Role of toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167(7):2001;3555.
20. Lardner A. The effects of extracellular pH on immune function. J. Leukoc. Biol. 69:2001;522.
21. Lopez D.H., Trevant A.S., Salamone G., Andonegui G., Raiden S., Giordano M.et al. Acidic pH increase the avidity of FcγR for immune complexes. Immunology. 98:1999;450.
22. Miyazawa K., Inoue K. Complement activation by human C-reactive protein in mild acidic conditions. J. Immunol. 145:1990;650.