Design, synthesis and biological evaluation of oxazolidinone-quinolone hybrids

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 10, 2003, Pages 2313-2319

  Hubschwerlen, Christian ^a   Specklin, Jean Luc ^a   Sigwalt, Christine ^a   Schroeder, Susanne ^a   Locher, Hans H ^a  

^a Morphochem AG Basel   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 7 [4 [2 FLUORO 4 [5 (METHOXYTHIOCARBONYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERAZIN 1 YL] 4 OXO 1,4 DIHYDRO[1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID; 6 OXO 2,3 DIHYDRO 6H 1 OXA 3,3A DIAZAPHENALENE 5 CARBOXYLIC ACID; 7 [3 [4 [5 (ACETYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYLAMINO]AZETIDIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDRO[1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 [3 [4 [5 (ACETYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYLAMINO]PYRROLIDIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDRO[1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 [3 [4 [5 (ACETYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYLAMINO]PYRROLIDIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 1 CARBOXYLIC ACID; 7 [4 [4 [5 (ACETYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [5 [5 (ACETYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL]PYRIDIN 2 YL] 1 PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDRO[1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 [4 [[5 (ACETYLAMINOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDRO[1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID; CIPROFLOXACIN; LINEZOLID; OXAZOLIDINONE DERIVATIVE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PH; PHARMACOPHORE;

ANTI-BACTERIAL AGENTS; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLIDINONES; PROTEIN BIOSYNTHESIS; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

NEGIBACTERIA; POSIBACTERIA;

EID: 0037447946     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00083-X     Document Type: Article

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