Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination

Biochemical Pharmacology

Volumn 65, Issue 8, 2003, Pages 1227-1241

  Griffin, Michael T ^a   Hsu, Jake Ching Hsuan ^b   Shehnaz, Darakhshanda ^b   Ehlert, Frederick J ^b  

^a CHAPMAN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenylyl cyclase; Coexpression; Cyclic AMP; Muscarinic receptors; Pertussis toxin; Phosphoinositide hydrolysis

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; OXOTREMORINE M; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; HYDROLYSIS; MATHEMATICAL ANALYSIS; NONHUMAN; NUCLEIC ACID STRUCTURE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN ISOLATION; RECEPTOR AFFINITY;

EID: 0037446481     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00068-6     Document Type: Article

References (26)

1. Arunlakshana O., Schild H.O. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14:1959;48-58.
2. Jordan B.A., Devi L.A. G-protein-coupled receptor heterodimerization modulates receptor function. Nature. 399:1999;697-700.
3. Eglen R.M., Hegde S.S., Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev. 48:1996;531-565.
4. Ehlert FJ, Thomas EA, Gerstin EH, Griffin MT. Muscarinic receptors and gastrointestinal smooth muscle. In: Eglen RM, editor. Muscarinic receptor subtypes in smooth muscle. Boca Raton: CRC Press; 1997. p. 92-147.
5. Ehlert F.J., Griffin M.T., Glidden P.F. The interaction of the enantiomers of aceclidine with subtypes of the muscarinic receptor. J. Pharmacol. Exp. Ther. 279:1996;1335-1344.
6. Thomas E.A., Hsu H.H., Griffin M.T., Hunter A.L., Luong T., Ehlert F.J. Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues. Mol. Pharmacol. 41:1992;718-726.
7. Candell L.M., Yun S.H., Tran L.L., Ehlert F.J. Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum. Mol. Pharmacol. 38:1990;689-697.
8. Berridge M.J., Downes C.P., Hanley M.R. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206:1982;587-595.
9. 3H ]inositol phospholipid turnover. In: Yamamura HI, editor. Methods in neurotransmitter receptor analysis. New York: Raven Press; 1990. p. 68-87.
10. Schultz J., Hamprecht B., Daly J.W. Accumulation of adenosine 3′:5′-cyclic monophosphate in clonal glial cells: labeling of intracellular adenine nucleotides with radioactive adenine. Proc. Natl. Acad Sci. U.S.A. 69:1972;1266-1270.
11. Gharagozloo P., Lazareno S., Popham A., Birdsall N.J. Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors. J. Med. Chem. 42:1999;438-445.
12. Ehlert F.J., Oliff H.S., Griffin M.T. The quaternary transformation products of N-(3-chloropropyl)-4-piperidinyl diphenylacetate and N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) have differential affinity for subtypes of the muscarinic receptor. J. Pharmacol. Exp. Ther. 276:1996;405-410.
13. 3 muscarinic receptors in the rat peripheral lung. Biochem. Pharmacol. 52:1996;643-658.
14. Peralta E.G., Ashkenazi A., Winslow J.W., Ramachandran J., Capon D.J. Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature. 334:1988;434-437.
15. Michell R.H. Inositol phospholipids and cell surface receptor function. Biochim. Biophys. Acta. 415:1975;81-147.
16. Birdsall N.J., Hulme E.C., Keen M. The binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium. Br. J. Pharmacol. 87:1986;307-316.
17. Birdsall N.J., Farries T., Gharagozloo P., Kobayashi S., Lazareno S., Sugimoto M. Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies. Mol. Pharmacol. 55:1999;778-786.
18. 2 acetylcholine receptors on the synthesis of cyclic AMP in CHO cells: dependence on time. Br. J. Pharmacol. 132:2001;1217-1228.
19. Gao B.N., Gilman A.G. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc. Natl. Acad. Sci. U.S.A. 88:1991;10178-10182.
20. 2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc. Natl. Acad. Sci. U.S.A. 88:1991;10173-10177.
21. sα. Biochemistry. 33:1994;12852-12959.
22. Tang W.J., Gilman A.G. Type-specific regulation of adenylyl cyclase by G protein βγ subunits. Science. 254:1991;1500-1503.
23. 2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science. 238:1987;672-675.
24. Lazareno S., Gharagozloo P., Kuonen D., Popham A., Birdsall N.J. Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol. Pharmacol. 53:1998;573-589.
25. Maggio R., Barbier P., Colelli A., Salvadori F., Demontis G., Corsini G.U. G protein-linked receptors: pharmacological evidence for the formation of heterodimers. J. Pharmacol. Exp. Ther. 291:1999;251-257.
26. 3-tail receptor. Eur. J. Pharmacol. 355:1998;267-274.