Efficacy and safety of ezetimibe coadministered with lovastatin in primary hypercholesterolemia

American Journal of Cardiology

Volumn 91, Issue 4, 2003, Pages 418-424

  Kerzner, Boris ^b   Corbelli, John ^b   Sharp, Stephan ^b   Lipka, Leslie J ^b   Melani, Lorenzo ^a   LeBeaut, Alexandre ^b   Suresh, Ramachandran ^b   Mukhopadhyay, Pabak ^b   Veltri, Enrico P ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EZETIMIBE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PLACEBO; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

EID: 0037441702     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(02)03236-8     Document Type: Article

References (14)

1. van Heek M., France C.F., Compton D.S., McLeod R.L., Yumibe N.P., Alton K.B., Sybertz E.J., Davis H.R. Jr. In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461. J Pharmacol Exp Ther. 283:1997;157-163.
2. van Heek M., Farley C., Compton D.S., Hoos L., Alton K.B., Sybertz E.J., Davis H.R. Jr. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br J Pharmacol. 129:2000;1748-1754.
3. Knopp R.H., Bays H., Manion C.V., Lipka L.J., Melani L., LeBeaut A.P., Suresh R., Veltri E.P. Effect of ezetimibe on serum concentrations of lipid-soluble vitamins. (abstr) Atherosclerosis. 2:(suppl):2001;90.
4. Dujovne CA, Ettinger MP, McNeer JF, Lipka LJ, LeBeaut AP, Suresh R, Yang B, Veltri EP. Efficacy and safety of a potent new selective cholesterol inhibitor, ezetimibe, in patients with hypercholesterolemia. Am J Cardiol 2002;90:1092-1097.
5. Knopp RH, Gitter H, Truitt T, Bays H, Manion CV, Lipka LJ, LeBeaut AP, Suresh R, Yang B, Veltri EP. Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur Heart J 2003; In press.
6. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA. 269:1993;3015-3023.
7. Executive Summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 285:2001;2486-2497.
8. Harris W.S., Held S.J., Dujovne C.A. Comparison of two scoring systems used to monitor diets in outpatient clinical trials. J Cardiovasc Risk. 2:1995;359-365.
9. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:1972;499-502.
10. Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis. 6th Ed. 1964;114 Little, Brown, Boston.
11. Kosoglou T., Meyer I., Cutler D.L., Musiol B., Yang B., Zhu Y., Maxwell S.E., Affrime M.B., Veltri E.P. Pharmacodynamic interaction between the selective cholesterol absorption inhibitor ezetimibe and lovastatin. (abstr) J Am Coll Cardiol. 37:(suppl A):2001;229A.
12. Ballantyne C., Houri J., Notarbartolo A., Melani L., Lipka L., LeBeaut A., Suresh R., Sun S., Veltri E. Ezetimibe co-administered with atorvastatin in 628 patients with primary hypercholesterolemia. (abstr) J Am Coll Cardiol. 39:(suppl A):2002;227A.
13. Davidson, M, McGarry T, Bettis R, Melani L, Lipka L, LeBeaut A, Suresh R, Sun S, Veltri E, for the Ezetimibe Study Group. Ezetimibe co-administered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-2134.
14. Melani L., Mills R., Hassman D., Lipetz R., Lipka L., LeBeaut A., Suresh R., Mukhopadhyay P., Veltri V. Ezetimibe co-administered with pravastatin in 538 patients with primary hypercholesterolemia. (abstr) J Am Coll Cardiol. 39:(suppl B):2002;139B.