Selective activation of deoxycytidine kinase by thymidine-5′-thiosulphate and release by deoxycytidine in human lymphocytes

Biochemical Pharmacology

Volumn 65, Issue 4, 2003, Pages 563-571

  Keszler, Gergely ^a   Szikla, Karoly ^a   Kazimierczuk, Zygmunt ^b   Spasokoukotskaja, Tatjana ^a   Sasvari Szekely, Maria ^a   Staub, Maria ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Deoxycytidine kinase; Deoxynucleoside salvage; DNA repair; Enzyme modulation; Nucleoside 5 thiosulphates; Thymidine kinases

Indexed keywords

CELL DNA; CELL EXTRACT; DEOXYADENOSINE; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; DEOXYRIBONUCLEOSIDE; ISOENZYME; NUCLEOTIDE; RIBONUCLEOSIDE; RIBOPURINE; RIBOURIDINE; THIOSULFATE; THYMIDINE; THYMIDINE KINASE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ARTICLE; BLOOD CELL; CELL FREE SYSTEM; CELL METABOLISM; CELL STIMULATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; DRUG METABOLISM; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; TONSIL CELL;

CELL-FREE SYSTEM; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; DEOXYCYTOSINE NUCLEOTIDES; ENZYME ACTIVATION; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; LYMPHOCYTES; THIOSULFATES; THYMIDINE; THYMIDINE KINASE; TONSIL;

EID: 0037441388     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01557-5     Document Type: Article

References (43)

1. Arner E.S., Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol. Ther. 67:1995;155-186.
2. Eriksson S., Kierdaszuk B., Munch-Petersen B., Oberg B., Johansson N.G. Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs. Biochem. Biophys. Res. Commun. 176:1991;586-592.
3. Tallman M.S., Hakimian D. Purine nucleoside analogs: emerging roles in indolent lymphoproliferative disorders. Blood. 86:1995;2463-2474.
4. Kierdaszuk B., Bohman C., Ullman B., Eriksson S. Substrate specificity of human deoxycytidine kinase toward antiviral 2′,3′-dideoxynucleoside analogs. Biochem. Pharmacol. 43:1992;197-206.
5. Pal S., Nair V. Phosphorylation of the anti-HIV compound (S,S)-isodideoxyadenosine by human recombinant deoxycytidine kinase. Biochem. Pharmacol. 60:2000;1505-1508.
6. Hatzis P., Al-Madhoon A.S., Jullig M., Petrakis T.G., Eriksson S., Talianidis I. The intracellular localization of deoxycytidine kinase. J. Biol. Chem. 273:1998;30239-30243.
7. Mitchell B.S., Song J.J., Jonsson E.E., Chen E., Dayton J.S. Regulation of human deoxycytidine kinase expression. Adv. Enzyme Regul. 33:1993;61-68.
8. Hengstschlager M., Denk C., Wawra E. Cell cycle regulation of deoxycytidine kinase. Evidence for post-transcriptional control. FEBS Lett. 321:1993;237-240.
9. Spasokoukotskaja T., Sasvari-Szekely M., Taljanidisz J., Staub M. Compartmentation of dCTP pools disappears after hydroxyurea or araC treatment in lymphocytes. FEBS Lett. 297:1992;151-154.
10. Sasvári-Székely M., Spasokukotskaja T., Staub M. Deoxyribocytidine is salvaged not only into DNA but also into phospholipid precursors. IV. Exogenous deoxycytidine can be used with the same efficacy as (ribo)cytidine for lipid activation. Biochem. Biophys. Res. Commun. 194:1993;966-972.
11. Bergmann A.M., Pinedo H.M., Jongsma A.P., Brouwer M., Ruiz van Haperen V.W., Veerman G., Leyva A., Eriksson S., Peters G.J. Decreased resistance to gemcitabine (2′,2′-difluorodeoxycytidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase. Biochem. Pharmacol. 57:1999;397-406.
12. Obata T., Endo Y., Tanaka M., Uchida H., Matsuda A., Sasaki T. Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides. Jpn. J. Cancer Res. 92:2001;793-798.
13. Veuger M.J., Heemskerk M.H., Honders M.W., Willemze R., Barge R.M. Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells. Blood. 99:2002;1373-1380.
14. Funato T., Satou J., Nishiyama Y., Fujimaki S., Miura T., Kaku M., Sasaki T. In vitro leukemia cell models of Ara-C resistance. Leuk. Res. 24:2000;535-541.
15. Beausejour C.M., Tremblay G., Momparler R.L. Potential of ribozymes against deoxycytidine kinase to confer drug resistance to cytosine nucleoside analogs. Biochem. Biophys. Res. Commun. 278:2000;569-575.
16. Stegmann A.P., Honders W.H., Willemze R., Ruiz van Haperen V.W., Landegent J.E. Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity. Blood. 85:1995;1188-1194.
17. Sasvari-Szekely M., Spasokoukotskaja T., Szoke M., Csapo Z., Turi A., Szanto I., Eriksson S., Staub M. Activation of deoxycytidine kinase during inhibition of DNA synthesis by 2-chloro-2′-deoxyadenosine (Cladribine) in human lymphocytes. Biochem. Pharmacol. 56:1998;1175-1179.
18. Csapo Z., Sasvari-Szekely M., Spasokoukotskaja T., Talianidis I., Eriksson S., Staub M. Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes. Biochem. Pharmacol. 61:2001;191-197.
19. Spasokoukotskaja T., Sasvari-Szekely M., Keszler G., Albertioni F., Eriksson S., Staub M. Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity. Eur. J. Cancer. 35:1999;1862-1867.
20. Ooi K., Ohkube T., Higashigawa M., Kawasaki H., Sakurai M. Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells. Biol. Pharm. Bull. 19:1996;1382-1383.
21. Csapo Z., Sasvari-Szekely M., Spasokoukotskaja T., Staub M. Modulation of human deoxycytidine kinase activity as a response to cellular stress induced by NaF. Acta Biochim. Pol. 48:2001;251-256.
22. Sasvari-Szekely M, Csapo Zs, Safrany G, Spasokoukotskaja T, Staub M. Activation of deoxycytidine kinase by gamma-irradiation. In: Eighth Symposium of European Society for Purine and Pyrimidine Metabolism in Man (ESSPPMM). Bruges, Belgium; 2001. p. 84.
23. Mohammad R.M., Beck F.W., Katato K., Hamdy N., Wall N., Al-Katib A. Potentiation of 2-chlorodeoxyadenosine activity by bryostatin 1 in the resistant chronic lymphocytic leukemia cell line (WSU-CLL): association with increased ratios of dCK/5′-NT and Bax/Bcl-2. Biol. Chem. 379:1998;1253-1261.
24. Kreder C.N., van Bree C., Peters G.J., Loves W.J., Haveman J. Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation. Oncol. Rep. 9:2002;141-144.
25. Arnaout M.K., Radomski K.M., Srivastava D.K., Tong X., Belt J.R., Raimondi S.C., Behm F.G., Santana V.M., Crom W.R., Mirro J. Jr., Ribeiro R.C. Treatment of childhood acute myelogenous leukemia with an intensive regimen (AML-87) that individualizes etoposide and cytarabine dosages: short- and long-term effects. Leukemia. 14:2000;1736-1742.
26. Orzeszko A., Niedzwiecka-Kornas A., Stolarski R., Kazimierczuk Z. Synthesis and conformation of nucleoside 5′-thiosulphates. Z. Natureforsch. 536:1998;1191-1196.
27. Stefanska J.Z., Starosciak B.J., Orzeszko A., Kazimierczuk Z. Antimicrobial activity of organic thiosulfates (Bunte salts). Pharmazie. 53:1998;190-192.
28. Iciek M.B., Rokita H.B., Wlodek L.B. Effects of diallyl disulfide and other donors of sulfane sulfur on the proliferation of human hepatoma cell line. Neoplasma. 48:2001;307-312.
29. Arner E.S.J., Spasokoukotskaja T., Eriksson S. Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. Biochem. Biophys. Res. Commun. 188:1992;712-718.
30. Sasvari-Szekely M., Piroth Z., Kazimierczuk Z., Staub M. A novel effect of the new antileukemic drug, 2-chloro-2′-deoxyadenosine, in human lymphocytes. Biochem. Biophys. Res. Commun. 203:1994;1378-1384.
31. Staub M., Spasokukotskaja T., Benczur M., Antoni F. DNA synthesis and nucleoside metabolism in human tonsillar lymphocyte subpopulations. Acta Otolaryngol. Suppl. 457:1987;118-124.
32. Golos B., Dzik J.M., Kazimierczuk Z., Ciesla J., Zielinski Z., Jankowska J., Kraszewski A., Stawinski J., Rode W., Shugar D. Interaction of thymidylate synthase with the 5′-thiophosphates, 5′-dithiophosphates, 5′-H-phosphonates and 5′-S-thiosulfates of 2′-deoxyuridine, thymidine and 5-fluoro-2′-deoxyuridine. Biol. Chem. 382:2001;1439-1445.
33. Taljanidisz J., Sasvari-Szekely M., Spasokukotskaja T., Antoni F., Staub M. Reversible permeabilization of lymphocytes destroys the incorporation of deoxythymidine but not of deoxycytidine. Biochim. Biophys. Acta. 885:1986;266-271.
34. Wang L.M., Kucera G.L. Deoxycytidine kinase is phosphorylated in vitro by protein kinase C alpha. Biochim. Biophys. Acta. 1224:1994;161-167.
35. Spasokoukotskaja T., Csapo Z., Sasvari-Szekely M., Virga S., Talianidis I., Eriksson S., Staub M. Effect of phosphorylation on deoxycytidine kinase activity. Adv. Exp. Med. Biol. 486:2000;281-285.
36. Tamura R.N., Cox G.S. Effect of pyrimidine deoxynucleosides and sodium butyrate on expression of the glycoprotein hormone alpha-subunit and placental alkaline phosphatase in HeLa cells. Biochim. Biophys. Acta. 968:1988;151-159.
37. Guittet O., Hakansson P., Voevodskaya N., Fridd S., Graslund A., Arakawa H., Nakamura Y., Thelander L. Mammalian P53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J. Biol. Chem. 276:2001;40647-40651.
38. Yamaguchi T., Matsuda K., Sagiya Y., Iwadate M., Fujino M.A., Nakamura Y., Arakawa H. p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint. Cancer Res. 61:2001;8256-8261.
39. Chandra J., Mansson E., Gogvadze V., Kaufmann S.H., Albertioni F., Orrenius S. Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood. 99:2002;655-663.
40. Groschel B., Kaufmann A., Hover G., Cinatl J., Doerr H.W., Noordhuis P., Loves W.J., Peters G.J., Cinatl J. Jr. 3′-Azido-2′,3′-dideoxythymidine induced deficiency of thymidine kinase 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells. Biochem. Pharmacol. 64:2002;239-246.
41. Xu Y.Z., Huang P., Plunkett W. Functional compartmentation of dCTP pools. Preferential utilisation of salvaged deoxycytidine for DNA repair in human lymphoblasts. J. Biol. Chem. 270:1995;631-637.
42. Van Den Neste E., Cardoen S., Husson B., Rosier J.F., Delacauw A., Ferrant A., Van den Berg G., Bontemps F. 2-Chloro -2′-deoxyadenosine inhibits DNA repair synthesis and potentiates UVC cytotoxicity in chronic lymphocytic leukemia B-lymphocytes. Leukemia. 16:2002;36-43.
43. Haddad J.J. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cell Signal. 14:2002;879-897. [review article].