Structural correlates of a functional streptokinase antigenic epitope: Serine 138 is an essential residue for antibody binding

Journal of Immunological Methods

Volumn 272, Issue 1-2, 2003, Pages 93-105

  Parhami Seren, Behnaz ^a   Seavey, Matthew ^a,c   Krudysz, Jolanta ^a   Tsantili, Panayota ^b  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Anti streptokinase monoclonal antibodies; Plasminogen activation; Site directed mutagenesis; Streptokinase; Streptokinase variants; Streptokinase plasminogen activator complex

Indexed keywords

ENZYME VARIANT; EPITOPE; LYSINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A4 3; PLASMINOGEN; PLASMINOGEN ACTIVATOR; SERINE 138; STREPTOKINASE; STREPTOKINASE ANTIBODY; STREPTOKINASE PLASMINOGEN ACTIVATOR COMPLEX; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CROSS REACTION; EPITOPE MAPPING; INHIBITION KINETICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CROSS REACTIONS; DNA, BACTERIAL; EPITOPE MAPPING; EPITOPES; GENES, BACTERIAL; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMINOGEN; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; STREPTOCOCCUS; STREPTOKINASE; VARIATION (GENETICS);

EID: 0037437912     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(02)00435-0     Document Type: Article

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