Structural and concentration effects on the deposition of tricyclic antidepressants in human hair

Forensic Science International

Volumn 84, Issue 1-3, 1997, Pages 225-236

  Pragst, F ^a   Rothe, M ^a   Hunger, J ^a   Thor, S ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Compliance analysis; Hair analysis; Tricyclic antidepressants

Indexed keywords

AMITRIPTYLINE; CLOMIPRAMINE; DOXEPIN; IMIPRAMINE; MAPROTILINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGED; CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG CONCENTRATION; DRUG STRUCTURE; FEMALE; HAIR ANALYSIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PATIENT MONITORING; PRIORITY JOURNAL;

EID: 0031031608     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(96)02066-X     Document Type: Conference Paper

References (19)

1. A. Tracqui, P. Kintz and P. Mangin, Hair analysis: a worthless tool for therapeutic compliance monitoring. Forensic Sci. Int., 70 (1995) 183-189.
2. I. Ishiyama, T. Nagai and S. Toshida, Detection of basic drugs (methamphetamine, antidepressants and nicotine) from human hair. J. Forensic Sci., 28 (1983) 380-385.
3. P. Kintz, B. Ludes and P. Mangin, Detection of drugs in human hair using Abott Adx, with confirmation by gas chromatography/mass spectrometry (GC/MS). J. Forensic Sci., 37 (1992) 328-331.
4. P. Kintz, A. Tracqui and P. Mangin, Detection of drugs in human hair for clinical and forensic applications. Int. J. Leg. Med., 105 (1992) 1-4.
5. A. Tracqui, P. Kreissig, P. Kintz, A. Pouliqen and P. Mangin. Hum. Exp. Toxicol., 11 (1992) 363-367.
6. P.M. Edelbroeck, E.J.M. De Haas and F.A. De Wolf, Liquid Chromatographic determination of amitriptyline and its metabolites in serum, with absorption on glass minimized. Clin. Chem., 28 (1982) 2143-2148.
7. S. A. Montgomery, Measurement of serum drug levels in the assessment of antidepressants. Brit. J. Clin. Pharmacol., 10 (1980) 411-416.
8. C.F. Gram, P. Kragh-Soerensen, C.B. Christensen, M. Moeller, O.L. Pedersen and P. Thayssen, Plasma level monitoring of antidepressants, theoretical basis and clinical application. Clin. Pharm. Ther., 33 (1983) 335-342.
9. R.N. Gupta and G. Molnar, Plasma levels and tricyclic anti-depressant therapy. Biopharm. Drug Dispos., 1 (1980) 259-278.
10. J.E. O'Brien and O.N. Hinsvark, GLC determination of doxepine plasma levels. J. Pharm. Sci., 65 (1976) 1068-1069.
11. M. Rothe and F. Pragst, Solvent optimization for the direct extraction of opiates from hair samples. J. Anal. Toxicol., 19 (1995) 236.
12. M. Rothe, F. Pragst, J. Hunger and S. Thor, Determination of carbamazepine and its metabolites in hair of epileptics. In V. Spiehler (ed), Proceedings of the 1994 Joint TIAFT / SOFT International Meeting, DABFT Newport Beach, CA, pp. 198-206.
13. W.A. Baumgartner and V.A. Hill, Sample preparation techniques. Forensic Sci. Int., 63 (1993) 121-135.
14. G.L. Henderson, Mechanism of drug incorporation into hair. Forensic Sci. Int., 63 (1993) 19-29.
15. A. Mizuno, T. Uematsu, A. Oshima, M. Nakamura and M. Nakashima, Analysis of nicotine content of hair for assessing individual cigarette-smoking behaviour. Ther. Drug Monit., 15 (1993) 99-104.
16. H. Sato, T. Uematsu, K. Yamada and M. Nakashima, Chlorpromazine in human scalp hair as an index of dosage history; comparison with simultaneously measured haloperidol. Eur. J. Clin. Pharmacol., 44 (1993) 439-444.
17. T. Uematsu, R. Sato, O. Fujimori and M. Nakashima, Human scalp hair as evidence of individual dosage history of haloperidol: a possible linkage of haloperidol excretion into hair with hair pigment. Arch. Dermatol. Res., 282 (1990) 120-125.
18. J. F. Wilson, S. Green, F. D. J. Dunstan, J. F. C. Wicks, C. Brewer and N.Perfect, Relationship between methadone dose, hair methadone concentration and hair colour in man. Ther. Drug Monit., 17 (1995) 419.
19. M. Rothe, F. Pragst, S. Thor and J. Hunger, Effect of pigmentation on the drug deposition in hair of grey-haired subjects. Forensic Sci. Int. (this issue).