The preparation of a fully differentiated "multiwarhead" siderophore precursor

Journal of Organic Chemistry

Volumn 68, Issue 1, 2003, Pages 191-194

  Murray, Aaron P ^a   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOSYANURATES;

CHEMICAL REACTIONS; DRUG DOSAGE; SYNTHESIS (CHEMICAL); UREA;

AROMATIC COMPOUNDS;

ANTIINFECTIVE AGENT; CYANURIC ACID; FLUOROURACIL; ISOCYANURIC ACID; RHODOTORULIC ACID; SIDEROPHORE; UNCLASSIFIED DRUG; UREA;

ARTICLE; DRUG CONFORMATION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; INDICATORS AND REAGENTS; MOLECULAR STRUCTURE; SIDEROPHORES; UREA;

EID: 0037428018     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo026391c     Document Type: Article

References (24)

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8. For relevant reviews and "Trojan-Horse" delivery concepts, see: (a) Roosenberg, J. M.; Lin, Y.-M.; Lu, Y.; Miller, M. J. Curr. Med. Chem. 2000, 7, 159. (b) Malouin, F.; Miller, M. J. Acc. Chem. Res. 1993, 26, 241. (c) Miller, M. J.; Malouin, F. The Development of Iron Chelators for Clinical Use; Bergeron, R. J., Brittenham, G. M., Eds.; CRC: Ann Arbor, 1994; p 275. Roosenberg, J. M.; Miller, M. J. J. Org. Chem. 2000, 65, 4833.
9. For relevant reviews and "Trojan-Horse" delivery concepts, see: (a) Roosenberg, J. M.; Lin, Y.-M.; Lu, Y.; Miller, M. J. Curr. Med. Chem. 2000, 7, 159. (b) Malouin, F.; Miller, M. J. Acc. Chem. Res. 1993, 26, 241. (c) Miller, M. J.; Malouin, F. The Development of Iron Chelators for Clinical Use; Bergeron, R. J., Brittenham, G. M., Eds.; CRC: Ann Arbor, 1994; p 275. Roosenberg, J. M.; Miller, M. J. J. Org. Chem. 2000, 65, 4833.
10. For relevant reviews and "Trojan-Horse" delivery concepts, see: (a) Roosenberg, J. M.; Lin, Y.-M.; Lu, Y.; Miller, M. J. Curr. Med. Chem. 2000, 7, 159. (b) Malouin, F.; Miller, M. J. Acc. Chem. Res. 1993, 26, 241. (c) Miller, M. J.; Malouin, F. The Development of Iron Chelators for Clinical Use; Bergeron, R. J., Brittenham, G. M., Eds.; CRC: Ann Arbor, 1994; p 275. Roosenberg, J. M.; Miller, M. J. J. Org. Chem. 2000, 65, 4833.
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18. (a) For the preparation of Boc OBHA, see: Lee, B. H.; Miller, M. J. J. Org. Chem. 1983, 48, 24. (b) For an excellent review of related chemistry relating to protected hydroxylamines, see: Romine, J. L. Org. Prep. Proced. Int. 1996, 28, 249.
19. (a) For the preparation of Boc OBHA, see: Lee, B. H.; Miller, M. J. J. Org. Chem. 1983, 48, 24. (b) For an excellent review of related chemistry relating to protected hydroxylamines, see: Romine, J. L. Org. Prep. Proced. Int. 1996, 28, 249.
20. For the preparation of Troc OBHA, see; Lee, B. H.; Gerfen, G. J.; Miller, M. J. J. Org. Chem. 1984, 49, 2418.
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23. Mitsunobu, O. Synthesis 1981, 1.
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