An intracellular targeted NLS peptide inhibitor of karyopherin α:NF-κB interactions

Biochemical and Biophysical Research Communications

Volumn 300, Issue 2, 2003, Pages 403-407

  Cunningham, Mark D ^a   Cleaveland, Jeffrey ^a   Nadler, Steven G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Karyopherin; NF B; Nuclear localization; Peptide; Transcription factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KARYOPHERIN ALPHA; KARYOPHERIN ALPHA 2; KPNA1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; INHIBITION KINETICS; INTRACELLULAR TRANSPORT; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG EFFECT; METABOLISM; PROTEIN TRANSPORT; SPECTROFLUOROMETRY;

ALPHA KARYOPHERINS; ANIMALS; COS CELLS; CYTOPLASM; DRUG DELIVERY SYSTEMS; NF-KAPPA B; NUCLEAR LOCALIZATION SIGNALS; PROTEIN TRANSPORT; SPECTROMETRY, FLUORESCENCE;

EID: 0037427511     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02863-2     Document Type: Article

References (15)

1. Marelli M., Dilworth D.J., Wozniak R.W., Aitchison J.D. The dynamics of karyopherin-mediated nuclear transport. Biochem. Cell Biol. 79:2001;603-612.
2. Weis K. Nucleocytoplasmic transport: cargo trafficking across the border. Curr. Opin. Cell Biol. 14:2002;328-335.
3. Chook Y.M., Blobel G. Karyopherins and nuclear import. Curr. Opin. Struct. Biol. 11:2001;703-715.
4. Nadler S.G., Tritschler D., Haffar O.K., Blake J., Bruce A.G., Cleaveland J.S. Differential expression and sequence-specific interaction of karyopherin. α with nuclear localization sequences J. Biol. Chem. 272:1997;4310-4315.
5. Boulikas T. Nuclear localization signals. Crit. Rev. Eukaryotic Gene Express. 3:1993;193-227.
6. Jans D.A., Xiao C.Y., Lam M.H.C. Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays. 22:2000;532-544.
7. Yamamoto Y., Gaynor R.B. Therapeutic potential of inhibition of the NF-. κ B pathway in the treatment of inflammation and cancer J. Clin. Invest. 107:2001;135-142.
8. Karin M., Cao Y., Greten F.R., Li Z.W. NF-. κ B in cancer: from innocent bystander to major culprit Nature Rev. 2:2002;301-310.
9. Pahl H.L. Activators and target genes of Rel/NF-. κ B transcription factors Oncogene. 18:1999;6853-6866.
10. Fujihara S.M., Cleaveland J.S., Grosmaire L.S., Berry K.K., Kennedy K.A., Blake J.J., Loy J., Rankin B.M., Ledbetter J.A., Nadler S.G. A D-amino acid peptide inhibitor of NF-. κ B nuclear localization is efficacious in models of inflammatory disease J. Immunol. 165:2000;1004-1012.
11. Fisher P.J., Prendergrast F.G., Ehrardt M.E., Urbauer J.L., Wand A.J., Sedarous S.S., McCormick D.J., Buckley P.J. Calmodulin interacts with amphiphilic peptides composed of all D-amino acids. Nature. 368:1994;651-653.
12. Miles A.J., Skubitz A.P., Furcht L.T., Fields G.B. A peptide model of basement membrane collagen. α1 (IV) 53-543 binds the α3β1 integrin J. Biol. Chem. 269:1994;30939-30945.
13. Feifel B., Schonfeld H.J., Christen P. D-peptide ligands for the co-chaperone Dnaj. J. Biol. Chem. 273:1998;11999-12002.
14. Zhou N.et al. Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines. J. Biol. Chem. 277:2002;17476-17485.
15. Forwood J.K., Harley V., Jans D.A. The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importing. β1 J. Biol. Chem. 276:2001;46575-46582.