Effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndrome in the Azithromycin in Acute Coronary Syndrome (AZACS) trial: A randomised controlled trial

Lancet

Volumn 361, Issue 9360, 2003, Pages 809-813

  Cercek, Bojan ^a   Shah, Prediman K ^a   Noc, Marko ^b   Zahger, Doron ^c   Zeymer, Uwe ^d   Matetzky, Shlomi ^e   Maurer, Gerald ^f   Mahrer, Peter ^g  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d KLINIKUM KASSEL   (Germany)

^e SHEBA MEDICAL CENTER   (Israel)

^f UNIVERSITY OF VIENNA   (Austria)

^g KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL SYMPTOM; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HOSPITAL ADMISSION; HUMAN; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RECURRENT DISEASE; REVASCULARIZATION; RISK ASSESSMENT; SHORT COURSE THERAPY; TREATMENT OUTCOME; UNSTABLE ANGINA PECTORIS;

EID: 0037426067     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)12706-7     Document Type: Article

References (18)

1. Falk E., Shah P.K., Fuster V. Coronary plaque rupture. Circulation. 92:1995;657-671.
2. Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet. 336:1990;827-830.
3. Cannon C.P., Weintraub W.S., Demopoulos L.A., et al. Comparison of early invasive and conservative strategies in patients with unstable coronary syndrome treated with glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med. 344:2001;1879-1887.
4. Schwartz G.G., Olsson G., Ezekowitz M.D., et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. JAMA. 285:2001;1711-1718.
5. Saikku P., Leinonen M., Matilla K., et al. Serologic evidence of an association of a novel chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet. 2:1988;983-986.
6. Kol A., Sukhova G.K., Lichtman A.H., Libby P. Chlamydial and human heat shock protein localizes in human atheroma and regulates macrophage tumor necrosis factor-a and matrix metalloproteinase expression. Circulation. 98:1998;300-307.
7. Van der Wal A.C., Becker A.E., van der Loos C.M., Das P.K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 89:1994;36-44.
8. Gupta S., Leatham E.W., Carrington D., et al. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation. 96:1997;404-407.
9. Muhlestein J.B., Anderson J.L., Carlquist J.F., et al. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease: primary clinical results of the ACADEMIC study. Circulation. 102:2000;1755-1760.
10. Anderson J.L., Muhlestein J.B., Carlquist J., et al. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: the Azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia (ACADEMIC) study. Circulation. 99:1999;1540-1547.
11. Gurfinkel E., Bozovich G., Daroca A., Beck E., Mautner B. Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study. Lancet. 350:1997;404-407.
12. Sinisalo J., Matilla K., Valtonen V., et al. Effect of 3 months of antimicrobial treatment with clarithromycin in acute non-Q-wave coronary syndrome. Circulation. 105:2002;1555-1560.
13. Stone A.F.M., Mendall M.A., Kaski J.-C., et al. Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: south Thames trial of antibiotics in myocardial infarction and unstable angina (STAMINA). Circulation. 106:2002;1219-1223.
14. Gurfinkel E., Bozovich G., Beck E., et al. Treatment with the antibiotic roxithromycin in patients with acute non-Q-wave coronary syndromes: the final report of the ROXIS study. Eur Heart J. 20:1999;121-127.
15. O'Connor C.M. Weekly intervention with zithromax for atherosclerosis and its related disorders: preliminary results of the WIZARD study. J Am Coll Cardiol. 40:2002;7.
16. Wood S. Roxithromycin strikes out on AMI. Heartwire News 2002.
17. Neumann F.-J., Kastrati A., Miethke T., et al. Treatment of Chlamydia pneumoniae infection with roxithromycin and effect on neointimal proliferation after coronary stent placement (ISAR-3): a randomized, double-blind, placebo controlled trial. Lancet. 357:2001;2086-2089.
18. Zhu J., Nieto F.J., Horne B.D., Anderson J.L., Muhlestein J.B., Epstein S.E. Prospective study of pathogen burden and risk of myocardial infarction or death. Circulation. 103:2001;45-51.