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1
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85045229505
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Kakeya H., Morishita M., Kobinata K., Osono M., Ishizuka M., Osada H. J. Antibiotics. 51:1998;1126.
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J. Antibiotics
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Kakeya, H.1
Morishita, M.2
Kobinata, K.3
Osono, M.4
Ishizuka, M.5
Osada, H.6
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2
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0033524896
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Kakeya H., Morishita M., Koshino H., Morita T., Kobayashi K., Osada H. J. Org. Chem. 64:1999;1052.
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(1999)
J. Org. Chem.
, vol.64
, pp. 1052
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Kakeya, H.1
Morishita, M.2
Koshino, H.3
Morita, T.4
Kobayashi, K.5
Osada, H.6
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4
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0034480581
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(a) For reviews of the subject, see: Stirling R.G., Chung K.F. Eur. Respir. J. 16:2000;1158. (b) Renauld J.C. J. Clin. Pathol. 54:2001;577.
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(2000)
Eur. Respir. J.
, vol.16
, pp. 1158
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Stirling, R.G.1
Chung, K.F.2
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5
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0034881918
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(a) For reviews of the subject, see: Stirling R.G., Chung K.F. Eur. Respir. J. 16:2000;1158 (b) Renauld J.C. J. Clin. Pathol. 54:2001;577.
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(2001)
J. Clin. Pathol.
, vol.54
, pp. 577
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Renauld, J.C.1
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6
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0032540412
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Takacs has described a conceptually identical approach as a generalized synthesis of 4-substituted oxazolidin-2-ones. See: Takacs J.M., Jaber M.R., Vellekoop A.S. J. Org. Chem. 63:1998;2742.
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(1998)
J. Org. Chem.
, vol.63
, pp. 2742
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Takacs, J.M.1
Jaber, M.R.2
Vellekoop, A.S.3
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7
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0032542166
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(a) Prashad M., Kim H.-Y., Har D., Repic O., Blacklock T.J. Tetrahedron Lett. 39:1998;9369.
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(1998)
Tetrahedron Lett.
, vol.39
, pp. 9369
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Prashad, M.1
Kim, H.-Y.2
Har, D.3
Repic, O.4
Blacklock, T.J.5
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10
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0033518561
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(b) Note that the corresponding enantioselective addition of enolsilanes to benzyloxyacetaldehyde using chiral Cu(II) complexes does not work well for phenylacetate derivatives. See: Evans D.A., Kozlowski M.C., Murry J.A., Burgey C.S., Campos K.R., Connell B.T., Staples R.J. J. Am. Chem. Soc. 121:1999;669.
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J. Am. Chem. Soc.
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Evans, D.A.1
Kozlowski, M.C.2
Murry, J.A.3
Burgey, C.S.4
Campos, K.R.5
Connell, B.T.6
Staples, R.J.7
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11
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85031197344
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note
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D=-71° for 1 (c=0.1, MeOH, 23°C; see ref 1).
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14
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85031201601
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note
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3H-thymidine (1 mCi/well) and then harvested and counted.
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15
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85031209997
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note
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5 cells/well. Compounds were dissolved in DMSO and serially diluted in media to give a final concentration of 0.3% DMSO. Compounds were added to cells 5 min prior to stimulating the cells with anti-CD3 (R&D Systems) at 1 mg/mL and anti-CD28 (Caltag Laboratories) at 200 μg/mL. Cells were cultured in a final volume of 200 μL at 37°C for 24 h. Supernatants were then harvested and cytokine levels measured by ELISA according to the manufacturer's instructions (Pharmingen).
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16
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85031203598
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note
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4 cells/well in serum free AIM V media (Gibco BRL) in 96-well plates with various concentrations of compound. After incubation for 24 h at 37°C, MTS (Promega) was added to each well at a final concentration of 333 μg/mL. Cell viability was determined after an additional 3 h incubation at 37°C by reading the plates at 490 nM absorbance. Inhibition was determined relative to cells cultured with 1% DMSO.
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18
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85031196623
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note
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(b) After the completion of our work, Carda, et al. reported a variation of the aldol/Curtius strategy towards cytoxazone 1 (but not 9) that utilizes an unusual chiral ketone derived in five steps from L-erthrulose.
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22
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0034798208
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Hameršak Z., Ljubović E., Merćep M., Mesić M., Šunjić V. Synthesis. 2001;1989.
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(2001)
Synthesis
, pp. 1989
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Hameršak, Z.1
Ljubović, E.2
Merćep, M.3
Mesić, M.4
Šunjić, V.5
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