A novel bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 8075-8082

  Kalscheuer, Rainer ^a   Steinbüchel, Alexander ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; ESTERIFICATION; GENES; LIPIDS;

STORAGE LIPIDS;

ENZYMES;

ACYL COENZYME A; ACYL COENZYME A:FATTY ALCOHOL ACYLTRANSFERASE; ACYLTRANSFERASE; DIACYLGLYCEROL ACYLTRANSFERASE; ESTER; LONG CHAIN ACYL COENZYME A ACYLTRANSFERASE; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WAX; WAX ESTER; WAX ESTER SYNTHASE; LONG CHAIN ALCOHOL O FATTY ACYLTRANSFERASE; LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE; PRIMER DNA;

ACINETOBACTER CALCOACETICUS; ARABIDOPSIS; ARTICLE; BIOTECHNOLOGICAL PROCEDURES; ENZYME ASSAY; LIPOGENESIS; MYCOBACTERIOSIS; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS; SEQUENCE HOMOLOGY; YEAST; ACINETOBACTER; BACTERIAL GENE; BINDING SITE; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS;

ACINETOBACTER CALCOACETICUS; ANIMALIA; ARABIDOPSIS; ARABIDOPSIS THALIANA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM SMEGMATIS; PSEUDOMONAS; PSEUDOMONAS CITRONELLOLIS; SIMMONDSIA CHINENSIS;

ACINETOBACTER; ACYLTRANSFERASES; BASE SEQUENCE; BINDING SITES; DIACYLGLYCEROL O-ACYLTRANSFERASE; DNA PRIMERS; ESTERS; GENES, BACTERIAL; KINETICS; MOLECULAR SEQUENCE DATA; TRIGLYCERIDES;

EID: 0037424538     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210533200     Document Type: Article

References (45)

1. Steinbüchel. A. (1991) in Biomaterials (Byrom, D., ed), pp. 123-213, MacMillan, London
2. Barksdale, L., and Kim, K. S. (1977) Bacteriol. Rev. 41, 217-372
3. Alvarez, H. M., Kalscheuer, R., and Steinbüchel A. (1997) Fett/Lipid 9, 239-246
4. Olukoshi, E. R., and Packter, N. M. (1994) Microbiology 140, 931-943
5. Fixter, L. M., Nagi, M., McCormack, J. G., and Fewson, C. A. (1986) J. Gen. Microbiol. 132, 3147-3157
6. Bell, R. M., and Coleman, R. A. (1980) Annu. Rev. Biochem. 49, 459-487
7. Lassner, M. (1997) Lipid Technol. 9, 5-9
8. Lehner, R., and Kuksis, A. (1996) Prog. Lipid Res. 35, 169-201
9. Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C., Welch, C. B., Lusis, A. J., Erickson, S. K., and Farese, R. V., Jr. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13018-13023
10. Hobbs, D. H., Lu, C., and Hills, M. J. (1999) FEBS Lett. 452, 145-149
11. Routaboul, J. M., Benning, C., Bechtold, N., Caboche, M., and Lepiniec, L. (1999) Plant Physiol. Biochem. 37, 831-840
12. Zou, J., Wei, Y., Jake, C., Kumar, A., Selvaraj, G., and Taylor, D. C. (1999) Plant J. 19, 645-653
13. Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., and Farese, R. V., Jr. (2001) J. Biol. Chem. 276, 38870-38876
14. Bouvier-Navé, P., Benveniste, P., Oelkers, P., Sturley, S. L., and Schaller, H. (2000) Eur. J. Biochem. 267, 85-96
15. Sandager, L., Gustavsson, M. H., Ståhl, U., Dahlqvist, A., Wiberg, E., Banas, A., Lenman, M., Ronne, H., and Stymne, S. (2002) J. Biol. Chem. 277, 6478-6482
16. Chen, H. C., and Farese, R. V., Jr. (2000) Trends Cardiovasc. Med. 10, 188-192
17. Dahlqvist, A., Ståhl, U., Lenman, M., Banas, A., Lee, M., Sandager, L., Ronne, H., and Stymne, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6487-6492
18. Lehner, R., and Kuksis, A. (1993) J. Biol. Chem. 268, 8781-8786
19. Stobart, K., Mancha, M., Lenman, M., Dahlqvist, A., and Stymne, S. (1997) Planta 203, 58-66
20. Ohlrogge, J. B., Pollard, M. R., and Stumpf, P. K. (1978) Lipids 13, 203-210
21. Ervin, J. L., Geigert, J., Neidleman, S. L., and Wadsworth, J. (1984) in Biotechnology for the oil and fats industry (Ratledge, C., Dawson, P., and Rattray, L., eds) pp. 217-222, American Oil Chemists Society, Champaign, IL
22. Lardizabal, K. D., Metz, J. G., Sakamoto, T., Hutton, W. C., Pollard, M. R., and Lassner, M. W. (2000) Plant Physiol. 122, 645-655
23. Bullock, W. O., Fernandez, J. M., and Stuart, J. M. (1987) BioTechniques 5, 376-379
24. Simon, R., Priefer, U., and Pühler, A. (1983) Bio/Technology 1, 784-791
25. Snapper, S. B., Melton, R. E., Mustafa, S., Kieser, T., and Jacobs, W. R. (1990) Mol. Microbiol. 4, 1911-1919
26. Kovach, M. E., Elzer, P. H., Hill, D. S., Robertson, G. T., Farris, M. A., Roop II, R. M., and Peterson, K. M. (1995) Gene (Amst.) 166, 175-176
27. Sambrook, J., Fritsch, E. F., and Maniatis, T. (eds) (1989) Molecular Cloning: a Laboratory Manual, p. A.1, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
28. Schlegel, H. G., Kaltwasser, H., and Gottschalk, G. (1961) Arch. Mikrobiol. 38, 209-222
29. Herrero, M., de Lorenzo, V., and Timmis, K. N. (1990) J. Bacteriol. 172, 6557-6567
30. Reiser, S., and Somerville, C. (1997) J. Bacteriol. 179, 2969-2975
31. Wältermann, M., Luftmann, H., Baumeister, D., Kalscheuer, R., and Steinbüchel, A. (2000) Microbiology 146, 1143-1149
32. Kalscheuer, R., Arenskötter, M., and Steinbüchel, A. (1999) Appl. Microbiol. Biotechnol. 52, 508-515
33. Overhage, J., Priefert, H., Rabenhorst, J., and Steinbüchel, A. (1999) Appl. Microbiol. Biotechnol. 52, 820-828
34. Altschul, S. F., Madden, T. L., Schäffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
35. Coleman, J. (1990) Mol. Gen. Genet. 232, 295-303
36. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry III, C. E. et al. (1998) Nature 393, 537-544
37. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry III, C. E. et al. (1998) Nature 396, 190-198
38. Stachelhaus, T., Mootz, H. D., Bergendahl, V., and Marahiel, M. A. (1998) J. Biol. Chem. 273, 22773-22781
39. Wang, L., Takayama, K., Goldman, D. S., and Schnoes, H. K. (1972) Biochim. Biophys. Acta 260, 41-48
40. Nakagawa, H., Kashiwabara, Y., and Matsuki, G. (1976) J. Biochem. 80, 923-928
41. Wun, C.-K., Barakat, H. A., and Walker R. W. (1977) Biochim. Biophys. Acta 488, 454-463
42. Garton, N. J., Christensen, H., Minnikin, D. E., Adegbola, R. A., and Barer, M. R. (2002) Microbiology 148, 2951-2958
43. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
44. Kyte, J., and Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132
45. Persson, B., and Argos, P. (1996) Protein Sci. 5, 363-371