UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes

Chemico-Biological Interactions

Volumn 145, Issue 2, 2003, Pages 201-211

  Ghaoui, Roula ^a,b   Sallustio, Benedetta C ^a,b   Burcham, Philip C ^a   Fontaine, Frank R ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b QUEEN ELIZABETH HOSPITAL   (Australia)

Author keywords

Carboxylic acid containing drugs; Clofibric acid; DNA damage; Mouse hepatocytes; UDP glucuronosyltransferase

Indexed keywords

CLOFIBRIC ACID; CLOFIBRIC ACID DERIVATIVE; DNA; GLUCURONOSYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA DAMAGE; GENOME; GLUCURONIDATION; LIVER CELL CULTURE; MALE; MOUSE; NONHUMAN;

ANIMALS; BORNANES; CELL DEATH; CLOFIBRIC ACID; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; MALE; MICE; TIME FACTORS;

EID: 0037422455     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(02)00253-3     Document Type: Article

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