The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression

Toxicology

Volumn 187, Issue 2-3, 2003, Pages 139-148

  Cheng, Jing ^a   Fu, Juan Ling ^a   Zhou, Zong Can ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

3 Hydroxysteroid dehydrogenase (3 HSD); Cytochrome P450 side chain cleavage (P450scc) enzyme; Manganese chloride; Primary Leydig cell; Steroidogenic acute regulatory protein (StAR); Testosterone

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL DERIVATIVE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; MANGANESE CHLORIDE; PREGNENOLONE; PROGESTERONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; LEYDIG CELL; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STEROIDOGENESIS; TESTOSTERONE SYNTHESIS;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CELLS, CULTURED; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; HYDROXYCHOLESTEROLS; LEYDIG CELLS; MALE; MANGANESE; MITOCHONDRIA; PHOSPHOPROTEINS; PREGNENOLONE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; STEROIDS; STIMULATION, CHEMICAL; TESTOSTERONE;

EID: 0037417447     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(03)00063-5     Document Type: Article

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