Immunodetection of Tropheryma whipplei in intestinal tissues from Dr. Whipple's 1907 patient [8]

New England Journal of Medicine

Volumn 348, Issue 14, 2003, Pages 1411-1412

  Dumler, J Stephen ^a   Baisden, Blaire L ^a   Yardley, John H ^a   Raoult, Didier ^b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b Université de Médecine   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA 16S; PERIODIC ACID; SCHIFF BASE;

BACTERIUM CULTURE; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; HISTOPATHOLOGY; HUMAN; IMMUNODETECTION; INFLAMMATORY INFILTRATE; INTESTINE LIPODYSTROPHY; LAMINA PROPRIA; LETTER; MACROPHAGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STAINING; TRANSMISSION ELECTRON MICROSCOPY; TROPHERYMA WHIPPELII;

HISTORY, 20TH CENTURY; MICROCOCCACEAE; WHIPPLE DISEASE;

EID: 0037417233     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200304033481425     Document Type: Letter

References (5)

1. Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907;18: 382-91.
2. Yardley JH, Hendrix TR. Combined electron and light microscopy in Whipple's disease. Bull Johns Hopkins Hosp 1961;109:80-98.
3. Relman DA, Schmidt TM, MacDermott RP, Falkow S. Identification of the uncultured bacillus of Whipple's disease. N Engl J Med 1992;327:293-301.
4. Raoult D, Birg ML, La Scola B, et al. Cultivation of the bacillus of Whipple's disease. N Engl J Med 2000;342:620-5. [Erratum, N Engl J Med 2000;342:1538.]
5. Baisden BL, Lepidi H, Raoult D, Argani P, Yardley JH, Dumler JS. Diagnosis of Whipple disease by immunohistochemical analysis: a sensitive and specific method for the detection of Tropheryma whipplei (the Whipple bacillus) in paraffin-embedded tissue. Am J Clin Pathol 2002;118:742-8.