Aldosterone blockade and heart failure

New England Journal of Medicine

Volumn 348, Issue 14, 2003, Pages 1380-1382

  Jessup, Mariell ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; SPIRONOLACTONE;

CLINICAL TRIAL; CORONARY ARTERY BLOOD FLOW; DEATH; DISEASE SEVERITY; DRUG EFFICACY; DRUG INDICATION; EDITORIAL; GYNECOMASTIA; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE FUNCTION; HOSPITALIZATION; HUMAN; HYPERKALEMIA; MORBIDITY; MORTALITY; PATIENT MONITORING; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; SEXUAL DYSFUNCTION; SIDE EFFECT; SUDDEN DEATH; SURVIVAL;

ALDOSTERONE; ALDOSTERONE ANTAGONISTS; HEART FAILURE, CONGESTIVE; HUMANS; MYOCARDIAL INFARCTION; RECEPTORS, ALDOSTERONE; SPIRONOLACTONE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0037417222     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMe030030     Document Type: Editorial

References (10)

1. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341:709-17.
2. Cicoira M, Zanolla L, Rossi A, et al. Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol 2002;40:304-10.
3. Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:1309-21.
4. Weber KT. Aldosterone and spironolactone in heart failure. N Engl J Med 1999;341:753-5.
5. Struthers AD. Impact of aldosterone on vascular pathophysiology. Congest Heart Fail 2002;8:18-22.
6. Weber KT. Aldosterone in congestive heart failure. N Engl J Med 2001;345:1689-97.
7. McMurray J, Pfeffer MA. New therapeutic options in congestive heart failure. Circulation 2002;105:2099-106.
8. Hunt SA, Baker DW, Chin MH, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 2001;38:2101-13.
9. Bozkurt B, Agoston I, Knowlton AA. Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. J Am Coll Cardiol 2003;41:211-4.
10. McNeil BJ. Shattuck Lecture - hidden barriers to improvement in the quality of care. N Engl J Med 2001;345:1612-20.