Synthesis of enantiomerically-pure [13C]aristeromycylcobalamin and its reactivity in dioldehydratase, glyceroldehydratase, ethanolamine ammonia-lyase and methylmalonyl-CoA mutase reactions

Chemistry - A European Journal

Volumn 9, Issue 3, 2003, Pages 652-660

  Weigl, Ulrich ^a   Heimberger, Martin ^a   Pierik, Antonio J ^b   Rétey, János ^a  

^a UNIVERSITY OF KARLSRUHE   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Cobalamines; Cofactors; Enzyme catalysis; EPR spectroscopy; Kinetics; Synthetic methods

Indexed keywords

CHEMICAL BONDS; ENZYMES; SYNTHESIS (CHEMICAL);

ENANTIOSELECTIVE SYNTHESIS;

HYDROCARBONS;

ADENOSINE; ARISTEROMYCIN; CARBON; COBALAMIN DERIVATIVE; COBALT; COBAMAMIDE; CYANOCOBALAMIN; DIOL DEHYDRATASE; DRUG DERIVATIVE; ETHANOLAMINE AMMONIA LYASE; GLYCEROL DEHYDRATASE; HYDRO LYASES; HYDROLYASE; METHANE; METHYLMALONYL COENZYME A MUTASE; NITROALKANE; NITROMETHANE; PROPANEDIOL DEHYDRATASE; RADICAL; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL BOND; CHEMISTRY; COENZYME; DRUG EFFECT; ELECTRON SPIN RESONANCE; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ISOTOPE LABELING; KINETICS; METABOLISM; METHODOLOGY; REACTION ANALYSIS; STEREOISOMERISM; SYNTHESIS;

ADENOSINE; CARBON RADIOISOTOPES; CATALYSIS; COBAMIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; ETHANOLAMINE AMMONIA-LYASE; HYDRO-LYASES; ISOTOPE LABELING; KINETICS; METHANE; METHYLMALONYL-COA MUTASE; NITROPARAFFINS; PROPANEDIOL DEHYDRATASE; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0037416020     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200390073     Document Type: Article

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