Exercise-induced ischemia initiates the second window of protection in humans independent of collateral recruitment

Journal of the American College of Cardiology

Volumn 41, Issue 7, 2003, Pages 1174-1182

  Lambiase, Pier D ^a   Edwards, Richard J ^a   Cusack, Michael R ^a   Bucknall, Clifford A ^a   Redwood, Simon R ^a   Marber, Michael S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BALLOON OCCLUSION; CLINICAL ARTICLE; CLINICAL PROTOCOL; COLLATERAL CIRCULATION; CONTROLLED STUDY; CORONARY ARTERY PRESSURE; EXERCISE ELECTROCARDIOGRAPHY; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART INFARCTION PREVENTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE EXTRASYSTOLE; HUMAN; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; PRIORITY JOURNAL; ST SEGMENT DEPRESSION; ST SEGMENT ELEVATION; STABLE ANGINA PECTORIS; TRANSLUMINAL CORONARY ANGIOPLASTY;

EID: 0037414093     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(03)00055-X     Document Type: Article

References (32)

1. Marber MS, Latchman DS, WaLker JM, Yellon DM. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 1993;88:1264-72.
2. Kuzuya T, Hoshida S, Yamashita N, et al. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circ Res 1993;72:1293-9.
3. Bolli R. The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase - an overview. Basic Res Cardiol 1996;91:57-63.
4. Dana A, Baxter GF, Walker JM, Yellon DM. Prolonging the delayed phase of myocardial protection: repetitive adenosine A1 receptor activation maintains rabbit myocardium in a preconditioned state. J Am Coll Cardiol 1998;31:1142-9.
5. Leesar MA, Stoddard MF, Dawn B, Jasti VG, Masden R, Bolli R. Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty. Circulation 2001;103:2935-41.
6. Dana A, Carroll R, Yellon DM, Walker JM. Exercise induced ischaemia results in both early and delayed myocardial adaptation: no role for adenosine (abstr)? Circulation 2000;102 Suppl 2:26.
7. Tomal F, Perino M, Ghini AS, et al. Exercise-induced myocardial ischemia triggers the early phase of preconditioning but not the late phase. Am J Cardiol 1999;83:586-8.
8. Edwards RJ, Redwood SR, Lambiase PD, Tomset E, Rakhit RD, Marber MS. Antiarrhythmic and anti-ischemic effects of angina in patients with and without coronary collaterals. Heart 2002;88:604-10.
9. Mac Alpin R, Kattus A. Adaptation to exercise in angina pectoris. Circulation 1966;33:183-201.
10. Pijls NH, van Son SJ, Kirkeeide RL, De Bruyne B, Gould KL. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation 1993;87:1354-67.
11. Li RA, Leppo M, Miki T, Seino S, Marban E. Molecular basis of electrocardiographic ST-segment elevation. Circ Res 2000;87:837-9.
12. Noma A. ATP-regulated K+ channels in cardiac muscle. Nature 1983;305:147-8.
13. Cohen MV, Yang XM, Downey JM. Attenuation of S-T segment elevation during repetitive coronary occlusions truly reflects the protection of ischemic preconditioning and is not an epiphenomenon. Basic Res Cardiol 1997;92:426-34.
14. Labovitz A, Lewen M, Kern M. Evaluation of left ventricular systolic and diastolic dysfunction during transient myocardial ischemia produced by angioplasty. J Am Coll Cardiol 1987;10:748-55.
15. Deutsch E, Berger M, Kussmaul WG, Hirshfield JW, Hermann HC, Laskey WK. Adaptation to ischemia during percutaneous transluminal coronary angioplasty: clinical haemodynamic and metabolic features. Circulation 1990;82:2044-51.
16. Tomai F, Crea F, Chiariello L, Gioffre PA. Ischemic preconditioning in humans: models, mediators, and clinical relevance. Circulation 1999;100:559-63.
17. Leesar MA, Stoddard MF, Manchikalapudi S, Bolli R. Bradykinin-induced preconditioning in patients undergoing coronary angioplasty. J Am Coll Cardiol 1999;34:639-50.
18. Matsubara T, Minatoguchi S, Matsuo H, et al. Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary, artery disease. J Am Coll Cardiol 2000;35:345-51.
19. Heusch G. Nitroglycerin and delayed preconditioning in humans: yet another new mechanism for an old drug? Circulation 2001;103:2876-8.
20. Billinger M, Fleisch M, Eberli FR, Garachemani A, Meier B, Seiler C. Is the development of myocardial tolerance to repeated ischemia in humans due to preconditioning or to collateral recruitment? J Am Coll Cardiol 1999;33:1027-35.
21. Jenkins DP, Kerac M, Zaman MJS, et al. Protecting the ischaemic myocardium using heat stress and ischaemic preconditioning. Med Sci Res 1997;25:569-72.
22. Mullenheim J, Schlack W, Frassdorf J, Heinen A, Preckel B, Thamer V. Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivo. Pflugers Arch 2001;442:178-87.
23. Lee T-M, Su S-F, Chou T-F, Lee Y-T, Tsai C-H. Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty. Circulation 2002;105:334-40.
24. Fletcher GF, Blaire SN, Blumentahl J, et al. Statement on exercise. Benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 1992;86:340-44.
25. Yamashita N, Baxter GF, Yellon DM. Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism. Heart 2001;85:331-6.
26. Tomai F. Warm up phenomenon and preconditioning in clinical practice. Heart 2002;87:99-100.
27. Marber MS, Walker JM, Latchman DS, et al. Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein. J Clin Invest 1994;93:1087-94.
28. Locke M, Tanguay RM, Klabundei RE, et al. Enhanced postischemic myocardial recovery following exercise induction of HSP 72. Am J Physiol 1995;269:H320-5.
29. Laughlin MH. Endothelium-mediated control of coronary vascular tone after chronic exercise training. Med Sci Sports Exerc 1995;27:1135-44.
30. Bolli R, Manchikalapudi S, Tang X-L, et al. The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Circ Res 1997;81:1094-7.
31. Bolli R. Late preconditioning. Circ Res 2000;87:972-84.
32. Bogaty P, Kingma JG, Guimond J, et al. Myocardial perfusion imaging findings and the role of adenosine in the warm-up angina phenomenon. J Am Coll Cardiol 2000;37:463-9.