Endothelial vasodilatory function is predicted by circulating apolipoprotein B and HDL in healthy humans

Lipids

Volumn 37, Issue 12, 2003, Pages 1135-1140

  Steer, Peter ^a   Hulthe, Johannes ^b   Millgård, Jonas ^a   Sarabi, Dennis M ^a   Basu, Samar ^a   Vessby, Bengt ^a   Lind, Lars ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR SYSTEM; OXIDATION; PARTICLE SIZE ANALYSIS; PROTEINS; REGRESSION ANALYSIS;

LIPIDS;

APOLIPOPROTEIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; METHACHOLINE CHLORIDE; NITROPRUSSIDE SODIUM; OXIDIZED LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; ATHEROSCLEROSIS; ATTENUATION; CARDIOVASCULAR DISEASE; CELL FUNCTION; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; EARLY DIAGNOSIS; ENDOTHELIUM CELL; ENDOTHELIUM DEPENDENT VASODILATATION; FEMALE; FOREARM BLOOD FLOW; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LIPOPROTEIN SYNTHESIS; MALE; MULTIPLE STEPWISE REGRESSION ANALYSIS; NORMAL HUMAN; OXIDATION; PARTICLE SIZE; PATHOLOGICAL ANATOMY; PLETHYSMOGRAPHY; POPULATION RESEARCH; PREDICTION; REGRESSION ANALYSIS; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS; VASODILATATION; VEIN OCCLUSION;

ADULT; AGED; APOLIPOPROTEINS B; ENDOTHELIUM, VASCULAR; FACTOR ANALYSIS, STATISTICAL; FEMALE; HUMANS; LIPOPROTEINS, HDL; MALE; MIDDLE AGED; RANDOM ALLOCATION; REFERENCE VALUES; VASODILATION;

EID: 0037413195     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-002-1010-3     Document Type: Article

References (48)

1. Jousilahti, P., Vartiainen, E., Pekkanen, J., Tuomilehto, J., Sundvall, J., and Puska, P. (1998) Serum Cholesterol Distribution and Coronary Heart Disease Risk: Observations and Predictions Among Middle-Aged Population in Eastern Finland, Circulation 97, 1087-1094.
2. Williams, K.J., and Tabas, I. (1995) The Response-to-Retention Hypothesis of Early Atherogenesis, Arterioscler. Thromb. Vasc. Biol. 15, 551-561.
3. Ylä-Herttuala, S., Palinski, W., Rosenfeld, M.E., Parthasarathy, S., Carew, T.E., Butler, S., Witztum, J.L., and Steinberg, D. (1989) Evidence for the Presence of Oxidatively Modified Low Density Lipoprotein in Atherosclerotic Lesions of Rabbit and Man, J. Clin. Invest. 84, 1086-1095.
4. Deckert, V., Brunet, A., Lantoine, F., Lizard, G., Millanvoyevan Brussel, E., Monier, S., Lagrost, L., David-Dufilho, M., Gambert, P., and Devynck, M.A. (1998) Inhibition by Cholesterol Oxides of NO Release from Human Vascular Endothelial Cells, Arterioscler. Thromb. Vasc. Biol. 18, 1054-1060.
5. Navab, M., Berliner, J.A., Watson, A.D., Hama, S.Y., Territo, M.C., Lusis, A.J., Shih, D.M., Van Lenten, B.J., Frank, J.S., Demer, L.L., et al. (1996) The Yin and Yang of Oxidation in the Development of the Fatty Streak. A Review Based on the 1994 George Lyman Duff Memorial Lecture, Arterioscler. Thromb. Vasc. Biol. 16, 831-842.
6. Ylä-Herttuala, S., Palinski, W., Butler, S.W., Picard, S., Steinberg, D., and Witztum, J.L. (1994) Rabbit and Human Atherosclerotic Lesions Contain IgG That Recognizes Epitopes of Oxidized LDL, Arterioscler. Thromb. 14, 32-40.
7. Palinski, W., Rosenfeld, M.E., Ylä-Herttuala, S., Gurtner, G.C., Socher, S.S., Butler, S.W., Parthasarathy, S., Carew, T.E., Steinberg, D., and Witztum, J.L. (1989) Low Density Lipoprotein Undergoes Oxidative Modification in vivo, Proc. Natl. Acad. Sci. USA 86, 1372-1376.
8. Puurunen, M., Manttari, M., Manninen, V., Tenkanen, L., Alfthan, G., Ehnholm, C., Vaarala, O., Aho, K., and Palosuo, T. (1994) Antibody Against Oxidized Low-Density Lipoprotein Predicting Myocardial Infarction, Arch. Intern. Med. 154, 2605-2609.
9. Fukumoto, M., Shoji, T., Emoto, M., Kawagishi, T., Okuno, Y., and Nishizawa, Y. (2000) Antibodies Against Oxidized LDL and Carotid Artery Intima-Media Thickness in a Healthy Population, Arterioscler. Thromb. Vasc. Biol. 20, 703-707.
10. Kugiyama, K., Kerns, S.A., Morrisett, J.D., Roberts, R., and Henry, P.D. (1990) Impairment of Endothelium-Dependent Arterial Relaxation by Lysolecithin in Modified Low-Density Lipoproteins, Nature 344, 160-162.
11. Galle, J., Ochslen, M., Schollmeyer, P., and Wanner, C. (1994) Oxidized Lipoproteins Inhibit Endothelium-Dependent Vasodilation. Effects of Pressure and High-Density Lipoprotein, Hypertension 23, 556-564.
12. Dupuis, J., Tardif, J.C., Cernacek, P., and Theroux, P. (1999) Cholesterol Reduction Rapidly Improves Endothelial Function After Acute Coronary Syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) Trial, Circulation 99, 3227-3233.
13. Glasser, S.P., Selwyn, A.P., and Ganz, P. (1996) Atherosclerosis: Risk Factors and the Vascular Endothelium, Am. Heart J. 131, 379-384.
14. Mäkimattila, S., Liu, M.L., Vakkilainen, J., Schlenzka, A., Lahdenperä, S., Syvanne, M., Mantysaari, M., Summanen, P., Bergholm, R., Taskinen, M.R., et al. (1999) Impaired Endothelium-Dependent Vasodilation in Type 2 Diabetes. Relation to LDL Size, Oxidized LDL, and Antioxidants, Diabetes Care 22, 973-981.
15. Creager, M.A., Cooke, J.P., Mendelsohn, M.E., Gallagher, S.J., Coleman, S.M., Loscalzo, J., and Dzau, V.J. (1990) Impaired Vasodilation of Forearm Resistance Vessels in Hypercholesterolemic Humans, J. Clin. Invest. 86, 228-234.
16. Egashira, K., Suzuki, S., Hirooka, Y., Kai, H., Sugimachi, M., Imaizumi, T., and Takeshita, A. (1995) Impaired Endothelium-Dependent Vasodilation of Large Epicardial and Resistance Coronary Arteries in Patients with Essential Hypertension. Different Responses to Acetylcholine and Substance P, Hypertension 25, 201-206.
17. Zeiher, A.M., Schachinger, V., and Minners, J. (1995) Long-Term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function, Circulation 92, 1094-1100.
18. Björnheden, T., Babyi, A., Bondjers, G., and Wiklund, O. (1996) Accumulation of Lipoprotein Fractions and Subfractions in the Arterial Wall, Determined in an in vitro Perfusion System, Atherosclerosis 123, 43-56.
19. Austin, M.A., Breslow, J.L., Hennekens, C.H., Buring, J.E., Willett, W.C., and Krauss, R.M. (1988) Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction, JAMA 260, 1917-1921.
20. Stampfer, M.J., Krauss, R.M., Ma, J., Blanche, P.J., Holl, L.G., Sacks, F.M., and Hennekens, C.H. (1996) A Prospective Study of Triglyceride Level, Low-Density Lipoprotein Particle Diameter, and Risk of Myocardial Infarction, JAMA 276, 882-888.
21. Lamarche, B., Tchernof, A., Moorjani, S., Cantin, B., Dagenais, G.R., Lupien, P.J., and Despres, J.P. (1997) Small, Dense Low-Density Lipoprotein Particles as a Predictor of the Risk of Ischemic Heart Disease in Men. Prospective Results from the Québec Cardiovascular Study, Circulation 95, 69-75.
22. Lind, L., Sarabi, M., and Millgård, J. (1998) Methodological Aspects of the Evaluation of Endothelium-Dependent Vasodilatation in the Human Forearm, Clin. Physiol. 18, 81-87.
23. Lind, L., Hall, J., Larsson, A., Annuk, M., Fellström, B., and Lithell, H. (2000) Evaluation of Endothelium-Dependent Vasodilation in the Human Peripheral Circulation, Clin. Physiol. 20, 440-448.
24. Havel, R.J., Eder, H.A., and Bragdon, J.H. (1955) The Distribution and Chemical Composition of Ultracentrifugally Separated Lipoproteins in Human Serum, J. Clin. Invest. 34, 1345-1353.
25. Seigler, L., and Wu, W.T. (1981) Separation of Serum High-Density Lipoprotein for Cholesterol Determination: Ultracentrifugation vs. Precipitation with Sodium Phosphotungstate and Magnesium Chloride, Clin. Chem. 27, 838-841.
26. Hulthe, J., Wiklund, O., Olsson, G., Fagerberg, B., Bokemark, L., Nivall, S., and Wikstrand, J. (1999) Computerized Measurement of LDL Particle Size in Human Serum. Reproducibility Studies and Evaluation of LDL Particle Size in Relation to Metabolic Variables and the Occurrence of Atherosclerosis, Scand. J. Clin. Lab. Invest. 59, 649-661.
27. Hulthe, J., Bokemark, L., Wikstrand, J., and Fagerberg, B. (2000) The Metabolic Syndrome, LDL Particle Size, and Atherosclerosis: The Atherosclerosis and Insulin Resistance (AIR) Study, Arterioscler. Thromb. Vasc. Biol. 20, 2140-2147.
28. Hulthe, J., Wikstrand, J., Lidell, A., Wendelhag, I., Hansson, G.K., and Wiklund, O. (1998) Antibody Titers Against Oxidized LDL Are Not Elevated in Patients with Familial Hypercholesterolemia, Arterioscler. Thromb. Vasc. Biol. 18, 1203-1211.
29. Hulthe, J., Bokemark, L., and Fagerberg, B. (2001) Antibodies to Oxidized LDL in Relation to Intima-Media Thickness in Carotid and Femoral Arteries in 58-Year-Old Subjectively Clinically Healthy Men, Arterioscler. Thromb. Vasc. Biol. 21, 101-107.
30. Palinski, W., Ylä-Herttuala, S., Rosenfeld, M.E., Butler, S.W., Socher, S.A., Parthasarathy, S., Curtiss, L.K., and Witztum, J.L. (1990) Antisera and Monoclonal Antibodies Specific for Epitopes Generated During Oxidative Modification of Low Density Lipoprotein, Arteriosclerosis 10, 325-335.
31. Griffin, M.E., McInerney, D., Fraser, A., Johnson, A.H., Collins, P.B., Owens, D., and Tomkin, G.H. (1997) Autoantibodies to Oxidized Low Density Lipoprotein: The Relationship to Low Density Lipoprotein Fatty Acid Composition in Diabetes, Diabet. Med. 14, 741-747.
32. Salonen, J.T., Ylä-Herttuala, S., Yamamoto, R., Butler, S., Korpela, H., Salonen, R., Nyyssonen, K., Palinski, W., and Witztum, J.L. (1992) Autoantibody Against Oxidized LDL and Progression of Carotid Atherosclerosis, Lancet 339, 883-887.
33. Sarabi, M., Millgård, J., and Lind, L. (1999) Effects of Age, Gender and Metabolic Factors on Endothelium-Dependent Vasodilation: A Population-Based Study, J. Intern. Med. 246, 265-274.
34. Toikka, J.O., Ahotupa, M., Viikari, J.S., Niinikoski, H., Taskinen, M., Irjala, K., Hartiala, J.J., and Raitakari, O.T. (1999) Constantly Low HDL-Cholesterol Concentration Relates to Endothelial Dysfunction and Increased in vivo LDL-Oxidation in Healthy Young Men, Atherosclerosis 147, 133-138.
35. Palinski, W., Miller, E., and Witztum, J.L. (1995) Immunization of Low Density Lipoprotein (LDL) Receptor-Deficient Rabbits with Homologous Malondialdehyde-Modified LDL Reduces Atherogenesis, Proc. Natl. Acad. Sci. USA 92, 821-825.
36. Castelli, W.P., Doyle, J.T., Gordon, T., Hames, C.G., Hjortland, M.C., Hulley, S.B., Kagan, A., and Zukel, W.J. (1977) HDL Cholesterol and Other Lipids in Coronary Heart Disease. The Cooperative Lipoprotein Phenotyping Study, Circulation 55, 767-772.
37. Sharrett, A.R., Patsch, W., Sorlie, P.D., Heiss, G., Bond, M.G., and Davis, C.E. (1994) Associations of Lipoprotein Cholesterols, Apolipoproteins A-I and B, and Triglycerides with Carotid Atherosclerosis and Coronary Heart Disease. The Atherosclerosis Risk in Communities (ARIC) Study, Arterioscler. Thromb. 14, 1098-1104.
38. Mäkimattila, S., Luoma, J.S., Ylä-Herttuala, S., Bergholm, R., Utriainen, T., Virkamaki, A., Mantysaari, M., Summanen, P., and Yki-Järvinen, H. (1999) Autoantibodies Against Oxidized LDL and Endothelium-Dependent Vasodilation in Insulin-Dependent Diabetes Mellitus, Atherosclerosis 147, 115-122.
39. Maggi, E., Marchesi, E., Ravetta, V., Martignoni, A., Finardi, G., and Bellomo, G. (1995) Presence of Autoantibodies Against Oxidatively Modified Low-Density Lipoprotein in Essential Hypertension: A Biochemical Signature of an Enhanced in vivo Low-Density Lipoprotein Oxidation, J. Hypertens. 13, 129-138.
40. van de Vijver, L.P., Steyger, R., van Poppel, G., Boer, J.M., Kruijssen, D.A., Seidell, J.C., and Princen, H.M. (1996) Auto-antibodies Against MDA-LDL in Subjects with Severe and Minor Atherosclerosis and Healthy Population Controls, Atherosclerosis 122, 245-253.
41. Vakkilainen, J., Mäkimattila, S., Seppälä-Lindroos, A., Vehkavaara, S., Lahdenperä, S., Groop, P.H., Taskinen, M.R., and Yki-Järvinen, H. (2000) Endothelial Dysfunction in Men with Small LDL Particles, Circulation 102, 716-721.
42. O'Brien, S.F., Watts, G.F., Playford, D.A., Burke, V., O'Neal, D.N., and Best, J.D. (1997) Low-Density Lipoprotein Size, High-Density Lipoprotein Concentration, and Endothelial Dysfunction in Non-insulin-dependent Diabetes, Diabet. Med. 14, 974-978.
43. Matsuda, Y., Hirata, K., Inoue, N., Suematsu, M., Kawashima, S., Akita, H., and Yokoyama, M. (1993) High-Density Lipoprotein Reverses Inhibitory Effect of Oxidized Low Density Lipoprotein on Endothelium-Dependent Arterial Relaxation, Circ. Res. 72, 1103-1109.
44. Laakso, M. (1996) Insulin Resistance and Coronary Heart Disease, Curr. Opin. Lipidol. 7, 217-226.
45. Hattori, Y., Suzuki, M., Tsushima, M., Yoshida, M., Tokunaga, Y., Wang, Y., Zhao, D., Takeuchi, M., Hara, Y., Ryomoto, K.I., et al. (1998) Development of Approximate Formula for LDL-chol, LDL-apo B and LDL-chol/LDL-apo B as Indices of Hyperapobetalipoproteinemia and Small Dense LDL, Atherosclerosis 138, 289-299.
46. Marques, V.P., Amar, J., Cambou, J.P., and Chamontin, B. (1996) Relationships Between Blood Pressure Components, Lipids and Lipoproteins in Normotensive Men, J. Hum. Hypertens. 10, 239-244.
47. Steer, P., Millgård, J., Sarabi, M.D., Basu, S., Vessby, B., Kahan, T., Edner, M., and Lind, L. (2002) Cardiac and Vascular Structure and Function Are Related to Lipid Peroxidation and Metabolism, Lipids 37, 231-236.
48. Goode, G.K., and Heagerty, A.M. (1995) In vitro responses of Human Peripheral Small Arteries in Hypercholesterolemia and Effects of Therapy, Circulation 91, 2898-2903.