Synthesis of acylglucuronides of drugs using immobilized dog liver microsomes octadecylsilica particles coated with phospholipid

Analytical Biochemistry

Volumn 317, Issue 1, 2003, Pages 99-106

  Kamimori, Hiroshi ^a   Ozaki, Yoshihisa ^a   Okabayashi, Yoshito ^a   Ueno, Kyoji ^a   Narita, Shigeru ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Acylglucuronide; Dog liver microsomes; Glucuronidation; Ketoprofen; Microsome immobilized ODS particles coated with phospholipid; S 1255; UDP glucuronic acid; UDP glucuronosyltransferase

Indexed keywords

DRUG PRODUCTS; GLUCOSE; HYDROPHOBICITY; LIVER; MASS SPECTROMETRY; PRODUCTIVITY;

ACYLGLUCURONIDE; GLUCURONIDATION; KETOPROFEN; LIVER MICROSOMES; ODS PARTICLES; S-1255; UDP GLUCURONOSYLTRANSFERASE; UDP-GLUCURONIC ACID;

PHOSPHOLIPIDS;

2 (1,3 BENZODIOXOL 5 YL) 6 ISOPROPYL 4 (4 METHOXYPHENYL) 2H CHROMENE 3 CARBOXYLIC ACID; 2 (BENZO[1,3]DIOXOL 5 YL) 6 ISOPROPYL 4 (4 METHOXYPHENYL) 2H CHROMENE 3 CARBOXYLIC ACID; DIPALMITOYLPHOSPHATIDYLCHOLINE; ENDOTHELIN RECEPTOR ANTAGONIST; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; KETOPROFEN; PHOSPHOLIPID; SILICON DIOXIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ABSORPTION; ARTICLE; BINDING AFFINITY; CATALYSIS; DOG; DRUG STRUCTURE; ENZYME ACTIVITY; HYDROPHOBICITY; LIVER MICROSOME; MASS SPECTROMETRY; MATERIAL COATING; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

CANIS FAMILIARIS; TRIXIS;

EID: 0037410072     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(03)00111-8     Document Type: Article

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