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Journal of Pharmaceutical and Biomedical Analysis

Volumn 24, Issue 3, 2001, Pages 477-485

LC-1H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems

(8) Mortensen, Rasmus W a,d Corcoran, Olivia b Cornett, Claus a Sidelmann, Ulla G c Troke, Jeff b Lindon, John C b Nicholson, Jeremy K b Hansen, Steen Honoré a

a UNIVERSITY OF COPENHAGEN (Denmark)

b Biomedical Sciences Division (United Kingdom)

c NOVO NORDISK A S (Denmark)

d LEO PHARMA A S (Denmark)

Author keywords

Acyl migration; Glucuronide; HPLC elution order; HPLC NMR; Reactive metabolites; S naproxen

Indexed keywords

GLUCURONIDE; NAPROXEN; NAPROXEN BETA 1 O GLUCURONIDE; UNCLASSIFIED DRUG; PROTON;

ARTICLE; CHEMICAL REACTION; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; METABOLITE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; CHEMISTRY; ISOLATION AND PURIFICATION; METHODOLOGY; STEREOISOMERISM; ULTRAVIOLET SPECTROPHOTOMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; MAGNETIC RESONANCE SPECTROSCOPY; NAPROXEN; PROTONS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0034746532 PISSN: 07317085 EISSN: None Source Type: Journal
DOI: 10.1016/S0731-7085(00)00453-2 Document Type: Article

Times cited : (25)

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