Local anesthetics modulate neuronal calcium signaling through multiple sites of action

Anesthesiology

Volumn 98, Issue 5, 2003, Pages 1139-1146

  Xu, Fang ^a   Garavito Aguilar, Zayra ^b   Recio Pinto, Esperanza ^b   Zhang, Jin ^b   Blanck, Thomas J J ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CAFFEINE; CALCIUM CHANNEL; CARBACHOL; FURA 2; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; POLOCAINE MPF; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; ROPIVACAINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AMIDES; ANESTHETICS, LOCAL; CALCIUM SIGNALING; CARBACHOL; CELL LINE; HUMANS; KINETICS; LIDOCAINE; MEPIVACAINE; NEURONS; POTASSIUM CHLORIDE; SODIUM CHANNELS; TUMOR CELLS, CULTURED;

EID: 0037407737     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200305000-00016     Document Type: Article

References (27)

1. Strichartz GR, Ritchie, JM: The action of local anesthetics on ion channels of excitable tissues, Local Anesthetics. Edited by Strichartz GR. Berlin, Heidelberg, New York, London, Paris, Tokyo, Springer-Verlag, 1987, pp 21-53
2. Moorman JR: Sodium Channels, Anesthesia Biologic Foundations. Edited by Yaksh TL, Lynch CIII, Zapol WM, Maze M, Biebuyck JF, Saidman LJ. Philadelphia, New York, Lippincott-Raven Publishers, 1998, pp 145-162
3. Hollmann MW, Durieux ME: Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology 2000; 93:858-75
4. Rossner KL, Freese KJ: Bupivacaine inhibition of L-type calcium current in ventricular cardiomyocytes of hamster. ANESTHESIOLOGY 1997; 87:926-34
5. Liu BG, Zhuang XL, Li ST, Xu GH, Brull SJ, Zhang JM: Effects of bupivacaine and ropivacaine on high-voltage-activated calcium currents of the dorsal horn neurons in newborn rats. ANESTHESIOLOGY 2001; 95:139-43
6. 2+ channels in rat anterior pituitary cells. Eur J Pharmacol 1998; 363:81-90
7. 2+ transients. ANESTHESIOLOGY 2000; 92:1746-56
8. Strichartz GR, Sanchez V, Arthur GR, Chafetz R, Martin D: Fundamental properties of local anesthetics. II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs. Anesth Analg 1990; 71:158-70
9. Strichartz GR, Berde, C B: Local Anesthetics, Anesthesia, 4th Edition. Edited by Miller RD. New York, Edinburgh, London, Madrid, Melbourne, Milan, Tokyo, Churchill Linvingstone, 1994, pp 489-521
10. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260:3440-50
11. Brown DL: Spinal, Epidural, and Caudal Anesthesia, Anesthesia, 4th Edition. Edited by Miller RD. New York, Edinburgh, London, Madrid, Melbourne, Milan, Tokyo, Churchhill Livingstone, 1994, pp 1505-1533
12. Wedel DJ: Nerve Blocks, Anesthesia, 4th Edition. Edited by Miller RD. New York, Edinburgh, London, Madrid, Melbourne, Milan, Tokyo, Churchhill Linvingstone, 1994, pp 1535-1564
13. Sharrock NE, Mather LE, Go G, Sculco TP: Arterial and pulmonary arterial concentrations of the enantiomers of bupivacaine after epidural injection in elderly patients. Anesth Analg 1998; 86:812-7
14. Kuramoto T, Werrbach-Perez K, Perez-Polo JR, Haber B: Membrane properties of a human neuroblastoma II: Effects of differentiation. J Neurosci Res 1981; 6:441-9
15. Forsythe ID, Lambert DG, Nahorski SR, Lindsdell P: Elevation of cytosolic calcium by cholinoceptor agonists in SH-SY5Y human neuroblastoma cells: estimation of the contribution of voltage-dependent currents. Br J Pharmacol 1992; 107:207-14
16. Toselli M, Tosetti P, Taglietti V: Functional changes in sodium conductances in the human neuroblastoma cell line SH-SY5Y during in vitro differentiation. J Neurophysiol 1996; 76:3920-7
17. Tosetti P, Taglietti V, Toselli M: Functional changes in potassium conductances of the human neuroblastoma cell line SH-SY5Y during in vitro differentiation. J Neurophysiol 1998; 79:648-58
18. 2+ stores in sarcoplasmic and endoplasmic reticulum. Science 1997; 275:1643-8
19. Hollmann MW, Fischer LG, Byford AM, Durieux ME: Local anesthetic inhibition of ml muscarinic acetylcholine signaling. ANESTHESIOLOGY 2000; 93: 497-509
20. Hollmann MW, Wieczorek KS, Berger A, Durieux ME: Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Gal-pha(q) protein function. Mol Pharmacol 2001; 59:294-301
21. Hollmann MW, Ritter CH, Henle P, de Klaver M, Kamatchi GL, Durieux ME: Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics. Br J Pharmacol 2001;133:207-16
22. Sullivan LM, Honemann CW, Arledge JA, Durieux ME: Synergistic inhibition of lysophosphatidic acid signaling by charged and unchanged local anesthetics. Anesth Analg 1999; 88:1117-24
23. Nietgen GW, Chan CK, Durieux ME: Inhibition of lysophosphatidate signaling by lidocaine and bupivacaine. ANESTHESIOLOGY 1997; 86:1112-9
24. Coyle DE, Sperelakis N: Bupivacaine and lidocaine blockade of calcium-mediated slow action potentials in guinea pig ventricular muscle. J Pharmacol Exp Ther 1987; 242: 1001-5
25. Sugiyama K, Muteki T: Local anesthetics depress the calcium current of rat sensory neurons in culture. ANESTHESIOLOGY 1994; 80:1369-78
26. 2+ current of single isolated frog sensory neurons. Brain Res 1988; 442:223-8
27. Weiss JN: The Hill equation revisited: uses and misuses. FASEB J 1997; 11:835-41