Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection

Journal of Immunology

Volumn 170, Issue 9, 2003, Pages 4693-4700

  DeSchoolmeester, Matthew L ^a   Little, Matthew C ^a   Rollins, Barrett J ^b   Else, Kathryn J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CHEMOKINE; CYTOKINE; INTERLEUKIN 12; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL POLARITY; CONTROLLED STUDY; CYTOKINE RELEASE; HELMINTHIASIS; IMMUNE RESPONSE; IMMUNITY; INFECTION RESISTANCE; INTESTINE INFECTION; LYMPH NODE; MACROPHAGE; MOUSE; NEMATODE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; TRICHURIS; TRICHURIS MURIS;

EID: 0037406738     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.9.4693     Document Type: Article

References (47)

1. Else, K., and D. Wakelin. 1988. The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice. Parasitology 96:543.
2. Else, K. J., F. D. Finkelman, C. R. Maliszewski, and R. K. Grencis. 1994. Cytokine-mediated regulation of chronic intestinal helminth infection. J. Exp. Med. 179:347.
3. Bancroft, A. J., A. N. McKenzie, and R. K. Grencis. 1998. A critical role for IL-13 in resistance to intestinal nematode infection. J. Immunol. 160:3453.
4. Faulkner, H., J. C. Renauld, J. Van Snick, and R. K. Grencis. 1998. Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris. Infect. Immun. 66:3832.
5. Richard, M., R. K. Grencis, N. E. Humphreys, J. C. Renauld, and J. Van Snick. 2000. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proc. Natl. Acad. Sci. USA 97:767.
6. Else, K. J., L. Hultner, and R. K. Grencis. 1992. Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice. Immunology 75:232.
7. Bancroft, A. J., K. J. Else, J. P. Sypek, and R. K. Grencis. 1997. Interleukin-12 promotes a chronic intestinal nematode infection. Eur. J. Immunol. 27:866.
8. Betts, C. J., and K. J. Else. 1999. Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris. Parasite Immunol. 21:45.
9. Else, K. J., and R. K. Grencis. 1996. Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris. Infect. Immun. 64:2950.
10. + T cell-mediated protection in reconstituted SCID mice. Parasitology 121:631.
11. Valente, A. J., D. T. Graves, C. E. Vialle-Valentin, R. Delgado, and C. J. Schwartz. 1988. Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture. Biochemistry 27:4162.
12. Yoshimura, T., E. A. Robinson, S. Tanaka, E. Appella, and E. J. Leonard. 1989. Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes. J. Immunol. 142:1956.
13. Matsushima, K., C. G. Larsen, G. C. Dubois, and J. J. Oppenheim. 1989. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J. Exp. Med. 169:1485.
14. Allavena, P., G. Bianchi, D. Zhou, J. van Damme, P. Jilek, S. Sozzani, and A. Mantovani. 1994. Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3. Eur. J. Immunol. 24:3233.
15. 2+ mobilization, and enzyme release. J. Immunol. 156:322.
16. Carr, M. W., S. J. Roth, E. Luther, S. S. Rose, and T. A. Springer. 1994. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. USA 91:3652.
17. Bischoff, S. C., M. Krieger, T. Brunner, A. Rot, T. von, V. M. Baggiolini, and C. A. Dahinden. 1993. RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. Eur. J. Immunol. 23:761.
18. Rutledge, B. J., H. Rayburn, R. Rosenberg, R. J. North, R. P. Gladue, C. L. Corless, and B. J. Rollins. 1995. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J. Immunol. 155:4838.
19. Fuentes, M. E., S. K. Durham, M. R. Swerdel, A. C. Lewin, D. S. Barton, J. R. Megill, R. Bravo, and S. A. Lira. 1995. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. J. Immunol. 155:5769.
20. Grewal, I. S., Rutledge, B. J., Fiorillo, J. A., Gu, L., Gladue, R. P., Flavell, R. A., and Rollins, B. J. 1997. Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1. J. Immunol. 159:401.
21. Gunn, M. D., N. A. Nelken, X. Liao, and L. T. Williams. 1997. Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J. Immunol. 158:376.
22. Nakamura, K., I. R. Williams, and T. S. Kupper. 1995. Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin. J. Invest. Dermatol. 105:635.
23. Lu, B., B. J. Rutledge, L. Gu, J. Fiorillo, N. W. Lukacs, S. L. Kunkel, R. North, C. Gerard, and B. J. Rollins. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187:601.
24. Chensue, S. W., K. S. Warmington, J. H. Ruth, P. S. Sanghi, P. Lincoln, and S. L. Kunkel. 1996. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157:4602.
25. Braun, M. C., E. Lahey, and B. L. Kelsall. 2000. Selective suppression of IL-12 production by chemoattractants. J. Immunol.164:3009.
26. Karpus, W. J., N. W. Lukacs, K. J. Kennedy, W. S. Smith, S. D. Hurst, and T. A. Barrett. 1997. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158:4129.
27. Karpus, W. J., and K. J. Kennedy. 1997. MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J. Leukocyte Biol. 62:681.
28. Lukacs, N. W., S. W. Chensue, W. J. Karpus, P. Lincoln, C. Keefer, R. M. Strieter, and S. L. Kunkel. 1997. C-C chemokines differentially alter interleukin-4 production from lymphocytes. Am. J. Pathol. 150:1861.
29. Gu, L., S. Tseng, R. M. Homer, C. Tam, M. Loda, and B. J. Rollins. 2000. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 404:407.
30. Reale, M., S. Frydas, R. C. Barbacane, F. C. Placido, I. Cataldo, D. Vacalis, A. Trakatellis, G. Anogianakis, M. Felaco, M. Di Gioacchino, et al. 1998. Induction of monocyte chemotactic protein-1 (MCP-1) and TNFα by Trichinella spiralis in serum of mice in vivo. Mol. Cell. Biochem. 179:1.
31. Frydas, S., T. Rallis, I. Theodorieds, M. N. Patsikas, C. Trakatellis, M. Di Gioacchino, and M. Felaco. 2000. Trichinella spiralis infection is mediated by MCP-1 and MIP-2, while echinococcus granulosus is strongly mediated by MCP-1 but not MIP-2. Int. J. Immunopathol. Pharmacol. 13:21.
32. Deng, Y., B. A. Vallance, C. M. Hogaboani, and S. M. Collins. 1998. Increased expression of the chemokines MCP-1 and eotaxin within the muscularis externa during intestinal inflammation. Gastroenterology 114:G3944.
33. Qiu, B., K. A. Frait, F. Reich, E. Komuniecki, and S. W. Chensue. 2001. Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Am. J. Pathol. 158:1503.
34. Grimm, M. C., S. K. Elsbury, P. Pavli, and W. F. Doe. 1996. Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. J. Leukocyte Biol. 59:804.
35. Karpus, W. J., K. J. Kennedy, S. L. Kunkel, and N. W. Lukacs. 1998. Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines. J. Exp. Med. 187:733.
36. c chain of the interleukin 2 receptor. Proc. Natl. Acad. Sci. USA 92:8353.
37. Huang, D. R., J. Wang, P. Kivisakk, B. J. Rollins, and R. M. Ransohoff. 2001. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193:713.
38. Wakelin, D. 1967. Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57:515.
39. Else, K. J., D. Wakelin, D. L. Wassom, and K. M. Hauda. 1990. MHC-restricted antibody responses to Trichuris muris excretory/secretory (E/S) antigen. Parasite Immunol. 12:509.
40. Else, K. J., and R. K. Grencis. 1991. Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection. Immunology 72:508.
41. Finkelman, F. D., and S. C. Morris. 1999. Development of an assay to measure in vivo cytokine production in the mouse. Int. Immunol. 11:1811.
42. Rosbottom, A., P. A. Knight, G. McLachlan, E. M. Thornton, S. W. Wright, H. R. Miller, and C. L. Scudamore. 2002. Chemokine and cytokine expression in murine intestinal epithelium following Nippostrongylus brasiliensis infection. Parasite Immunol. 24:67.
43. Matsukawa, A., C. M. Hogaboam, N. W. Lukacs, P. M. Lincoln, R. M. Strieter, and S. L. Kunkel. 1999. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J. Immunol. 163:6148.
44. Chae, P., M. Im, F. Gibson, Y. Jiang, and D. T. Graves. 2002. Mice lacking monocyte chemoattractant protein 1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment. Infect. Immun. 70:3164.
45. Peters, W., M. Dupuis, and I. F. Charo. 2000. A mechanism for the impaired IFN-γ production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses. J. Immunol. 165:7072.
46. Tylaska, L. A., L. Boring, W. Weng, R. Aiello, I. F. Charo, B. J. Rollins, and R. P. Gladue. 2002. CCR2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine 18:184.
47. Traynor, T. R., A. C. Herring, M. E. Dorf, W. A. Kuziel, G. B. Toews, and G. B. Huffnagle. 2002. Differential roles of CC chemokine ligand 2/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity. J. Immunol. 168:4659.