Solubilization of flurbiprofen in pH-surfactant solutions

Journal of Pharmaceutical Sciences

Volumn 92, Issue 5, 2003, Pages 951-956

  Li, Ping ^a   Zhao, Luwei ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b SANOFI   (France)

Author keywords

Flurbiprofen; Micellized surfactant; Model; pH surfactant; Solubility

Indexed keywords

FLURBIPROFEN; POLYSORBATE 80;

ARTICLE; DRUG SOLUBILITY; DRUG STRUCTURE; MICELLE; PH;

EID: 0037406562     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10360     Document Type: Article

References (18)

1. Rippie EG, Lamb DJ, Romig PW. 1964. Solubilization of weakly acidic and basic drugs by aqueous solutions of polysorbate 80. J Pharm Sci 53:1346-1348.
2. Dyer DL. 1959. The effect of pH on solubilization of weak acids and bases. J Coll Sci 14:640-645.
3. Collett JH, Koo L. 1975. Interaction of substituted benzoic acids with polysorbate 20 micelles. J Pharm Sci 64:1253-125.
4. Park JY, Rippie EG. 1977. Micellar distribution equilibria: Ultracentrifugal study of apparent partition coefficients. J Pharm Sci 66:858-861.
5. Lopes A, Macanlta AL, Pina FS, Melo E, Wamhoff H. 1992. Multiequilibria of 2-(2′-furanyl)-1H-benzimidazole neutral and protonated forms in the presence of amphiphilic aggregates. Environ Sci Technol 26: 2448-2453.
6. Castro DB, Gameiro P, Guimaraes C, Lima JLFC, Reis S. 1998. Acid/base properties of β-blockers and benzodiazepines in sodium dodecyl sulfate micelles. A spectrophotometric and potentiometric study. J Pharm Sci 87:356-359.
7. Li P, Tabibi SE, Yalkowsky SH. 1999. Solubilization of ionized and unionized flavopiridol by ethanol and polysorbate 20. J Pharm Sci 88:507-509.
8. Li P, Tabibi SE, Yalkowsky SH. Solubilization of flavopiridol by pH control combined with cosolvents, surfactants, or complexants. J Pharm Sci 88: 945-947.
9. Jinno J, OH DM, Crison JR, Amidon GL. 2000. Dissolution of ionizable water-insoluble drugs: The combined effect of pH and surfactant. J Pharm Sci 89:268-274.
10. Jain N, Yang G, Tabibi SE, Yalkowsky SH. 2001. Solubilization of NSC-639829. Int J Pharm 225: 41-47.
11. Attwood D, Florence AT. 1983. Surfactant systems. Their chemistry, pharmacy and biology. New York: Chapman and Hall, pp 236-237.
12. Berezin IV, Martinek K, Yatsimirskii AK. 1973. Physicochemical foundations of micellar catalysis. Russ Chem Rev 42:787-802.
13. de Castro B, Gameiro P, Guimaráes C, Lima JLFC, Reis S. 1998. Acid/base properties of β-blockers and benzodiazepines in sodium dodecyl sulfate micelles. A spectrophotometric and potentiometric study. J Pharm Sci 87:356-359.
14. Li P, Zhao L. 2002. Cosolubilization of non-polar drugs in polysorbate 80 solutions. Int J Pharm 249: 211-217.
15. Higuchi T, Connors K. 1965. Phase-solubility techniques. Adv Anal Inst 4:117-212.
16. Anderson BD, Conradi RA. 1985. Predictive relationships in the water solubility of salts of a nonsteroidal anti-inflammatory drug. J Pharm Sci 74: 815-820.
17. Park KM, Kim CK. 1999. Preparation and evaluation of flurbiprofen-loaded microemulsion forparenteral delivery. Int J Pharm 181:173-179.
18. Avdeef A, Berger CM, Brownell C. 2000. pH-metric solubility 2: Correlation between the acid-base titration and the saturation shake-flask solubility-pH method. Pharm Res 17:85-89.