The cell-rounding activity of the vesicular stomatitis virus matrix protein is due to the induction of cell death

Journal of Virology

Volumn 77, Issue 9, 2003, Pages 5524-5528

  Kopecky, Sarah A ^a   Lyles, Douglas S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MATRIX PROTEIN; MESSENGER RNA; PLASMID DNA; PROTEIN BCL 2; TUBULIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HELA CELL; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION;

APOPTOSIS; GENE EXPRESSION; HELA CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TRANSFECTION; VESICULAR STOMATITIS-INDIANA VIRUS; VIRAL MATRIX PROTEINS;

EID: 0037405741     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.9.5524-5528.2003     Document Type: Article

References (28)

1. Ahmed, M., and D. S. Lyles. 1998. Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III. J. Virol. 72:8413-8419.
2. Ahmed, M., M. O. McKenzie, S. Puckett, M. Hojnacki, L. Poliquin, and D. S. Lyles. Ability of matrix protein of vesicular stomatitis virus to suppress beta interferon gene expression is genetically correlated with the inhibition of host RNA and protein synthesis. J. Virol., in press.
3. Barge, A., Y. Gaudin, P. Coulon, and R. H. Ruigrok. 1993. Vesicular stomatitis virus M protein may be inside the ribonucleocapsid coil. J. Virol. 67:7246-7253.
4. Black, B. L., G. Brewer, and D. S. Lyles. 1994. Effect of vesicular stomatitis virus matrix protein on host-directed translation in vivo. J. Virol. 68:555-560.
5. Black, B. L., and D. S. Lyles. 1992. Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo. J. Virol. 66:4058-4064.
6. Black, B. L., R. B. Rhodes, M. McKenzie, and D. S. Lyles. 1993. The role of vesicular stomatitis virus matrix protein in inhibition of host-directed gene expression is genetically separable from its function in virus assembly. J. Virol. 67:4814-4821.
7. Blondel, D., G. G. Harmison, and M. Schubert. 1990. Role of matrix protein in cytopathogenesis of vesicular stomatitis virus. J. Virol. 64:1716-1725.
8. Connor, J. H., and D. S. Lyles. 2002. Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1. J. Virol. 76:10177-10187.
9. Ferran, M. C., and J. M. Lucas-Lenard. 1997. The vesicular stomatitis virus matrix protein inhibits transcription from the human beta interferon promoter. J. Virol. 71:371-377.
10. Her, L. S., E. Lund, and J. E. Dahlberg. 1997. Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus. Science 276:1845-1848.
11. Huneycutt, B. S., Z. Bi, C. J. Aoki, and C. S. Reiss. 1993. Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice. J. Virol. 67:6698-6706.
12. Kaptur, P. E., R. B. Rhodes, and D. S. Lyles. 1991. Sequences of the vesicular stomatitis virus matrix protein involved in binding to nucleocapsids. J. Virol. 65:1057-1065.
13. Kopecky, S. A., and D. S. Lyles. Contrasting effects of matrix protein on apoptosis in HeLa and BHK cells infected with vesicular stomatitis virus are due to inhibition of host gene expression. J. Virol., in press.
14. Kopecky, S. A., M. C. Willingham, and D. S. Lyles. 2001. Matrix protein and another viral component contribute to induction of apoptosis in cells infected with vesicular stomatitis virus. J. Virol. 75:12169-12181.
15. Lyles, D. S., and M. O. McKenzie. 1997. Activity of vesicular stomatitis virus M protein mutants in cell rounding is correlated with the ability to inhibit host gene expression and is not correlated with virus assembly function. Virology 299:77-89.
16. Lyles, D. S., M. O. McKenzie, M. Ahmed, and S. C. Woolwine. 1996. Potency of wild-type and temperature-sensitive vesicular stomatitis virus matrix protein in the inhibition of host-directed gene expression. Virology 225:172-180.
17. Melki, R., Y. Gaudin, and D. Blondel. 1994. Interaction between tubulin and the viral matrix protein of vesicular stomatitis virus: possible implications in the viral cytopathic effect. Virology 202:339-347.
18. Muller, U., U. Steinhoff, L. F. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
19. Neely, M. D., K. R. Sidell, D. G. Graham, and T. J. Montine. 1999. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. J. Neurochem. 72:2323-2333.
20. Newcomb, W. W., and J. C. Brown. 1981. Role of the vesicular stomatitis virus matrix protein in maintaining the viral nucleocapsid in the condensed form found in native virions. J. Virol. 39:295-299.
21. Paik, S. Y., A. C. Banerjea, G. G. Harmison, C. J. Chen, and M. Schubert. 1995. Inducible and conditional inhibition of human immunodeficiency virus proviral expression by vesicular stomatitis virus matrix protein. J. Virol. 69:3529-3537.
22. Petersen, J. M., L. S. Her, V. Varvel, E. Lund, and J. E. Dahlberg. 2000. The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes. Mol. Cell. Biol. 20:8590-8601.
23. Vikman, K., B. Robertson, G. Grant, A. Liljeborg, and K. Kristensson. 1998. Interferon-gamma receptors are expressed at synapses in the rat superficial dorsal horn and lateral spinal nucleus. J. Neurocytol. 27:749-759.
24. Volberg, T., A. D. Bershadsky, M. Elbaum, A. Gazit, A. Levitzki, and B. Geiger. 2000. Disruption of microtubules in living cells by tyrphostin AG-1714. Cell Motil. Cytoskeleton 45:223-234.
25. von Kobbe, C., J. M. van Deursen, J. P. Rodrigues, D. Sitterlin, A. Bachi, X. Wu, M. Wilm, M. Carmo-Fonseca, and E. Izaurralde. 2000. Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin nup98. Mol. Cell 6:1243-1252.
26. Wang, E., and R. D. Goldman. 1978. Functions of cytoplasmic fibers in intracellular movements in BHK-21 cells. J. Cell Biol. 79:708-726.
27. Yuan, H., S. Puckett, and D. S. Lyles. 2001. Inhibition of host transcription by vesicular stomatitis virus involves a novel mechanism that is independent of phosphorylation of TATA-binding protein (TBP) or association of TBP with TBP-associated factor subunits. J. Virol. 75:4453-4458.
28. Yuan, H., B. K. Yoza, and D. S. Lyles. 1998. Inhibition of host RNA polymerase II-dependent transcription by vesicular stomatitis virus results from inactivation of TFIID. Virology 251:383-392.