Evidence for central command activation of the human insular cortex during exercise

Journal of Applied Physiology

Volumn 94, Issue 5, 2003, Pages 1726-1734

  Williamson, J W ^a   McColl, R ^b   Mathews, D ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autonomic control; Brain imaging; Brain mapping; Magnetic resonance imaging; Single photon emission computed tomography

Indexed keywords

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE REGULATION; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN IMAGING; BRAIN MAPPING; CENTRAL COMMAND SIGNAL; CINGULATE GYRUS; CONTROLLED STUDY; EXERCISE; FEMALE; HAND GRIP; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; IMAGE PROCESSING; INSULA; MALE; MEAN ARTERIAL PRESSURE; MECHANOREFLEX; METABOREFLEX; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; REFLEX; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 0037405192     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01152.2002     Document Type: Article

References (30)

1. Ackermann H, Riecker A, Mathiak K, Erb M, Grodd W, and Wildgrubber D. Rate-dependent activation of prefrontal-insular-cerebellar network during passive listening to trains of click stimuli: an fMRI study. Neuroreport 12: 4087-4092, 2001.
2. Borg G. Perceived exertion: a note on history and methods. Med Sci Sports Exerc 5: 90-93, 1973.
3. Cechetto DF and Saper CB. Role of the cerebral cortex in autonomic function. In: Central Regulation of Autonomic Function. Oxford, UK: Oxford University Press, 1990, p. 208-223.
4. Critchley HD, Corfield DR, Chandler MP, Mathis CJ, and Dolan RJ. Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans. J Physiol 523: 259-270, 2000.
5. Kaufman M and Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 10, p. 381-447.
6. King AB, Menon RS, Hachinski V, and Cechetto DF. Human forebrain activation by visceral stimuli. J Comp Neurol 413: 572-582, 1999.
7. Leonard B, Mitchell JH, Mizuno M, Rube N, Saltin B, and Secher NH. Partial neuromuscular blockade and cardiovascular responses to static exercise in man. J Physiol 359: 365-379, 1985.
8. McColl RW, Blackburn T, and Peshock RM. Tools for analysis of fMRI data. Soc Photooptic Instrum Eng Med Imag 2707: 1197-1206, 1996.
9. Mitchell JH. Neural control of the circulation during exercise. Med Sci Sports Exerc 22: 141-154, 1990.
10. McIlveen SA, Hayes SG, and Kaufman MP. Both central command and the exercise pressor reflex reset the carotid sinus baroreflex. Am J Physiol Heart Circ Physiol 280: H1454-H1463, 2001.
11. Nowak M, Olsen K, Law I, Holm S, Paulson O, and Secher NH. Command-related distribution of regional cerebral blood flow during attempted handgrip. J Appl Physiol 86: 819-824, 1999.
12. Nowak M, Holm S, Secher NH, and Friberg L. PET and fMRI during light handgrip exercise: cardiovascular responses and insular activation. Proc 5th Internat Confer Human Brain Mapping, 1999, p. S486.
13. Nowak M. The insula and central command influence on cardiovascular regulation during exercise: a PET and fMRI study. In: University of Copenhagen Dissertation, 2000, p. 1-93.
14. Oppenheimer SM, Gelb A, Girvin JP, and Hachinski VC. Cardiovascular effects of human insular cortex stimulation. Neurology 42: 1727-1732, 1992.
15. Oppenheimer SM, Kulshreshtha N, Lenz FA, Zhang Z, Rowland LH, and Dougherty PM. Distribution of cardiovascular related cells within the human thalamus. Clin Auton Res 8: 173-179, 1998.
16. Raichle ME. Circulatory and metabolic correlates of brain function in normal humans. In: Handbook of Physiology. The Nervous System. Higher Functions of the Brain. Bethesda, MD: Am Physiol. Soc., 1987, sect. 1, vol. V, pt. 2, chapt. 16, p. 643-674.
17. Rainville P, Duncan GH, Price DD, Carrier B, and Bushnell MC. Pain affect encoded in the anterior cingulate but not somatosensory cortex. Science 277: 968-970, 1997.
18. Ruggiero DA, Mraovitch S, Granata AR, Anwar M, and Reis DJ. A role of insular cortex in cardiovascular function. J Comp Neurol 257: 189-207, 1987.
19. Saper CB. Convergence of autonomic and limbic connections in the insular cortex of the rat. J Comp Neurol 210: 163-173, 1982.
20. Thornton JM, Aziz T, Schlugman D, and Paterson DJ. Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans. J Physiol 539: 615-621, 2002.
21. Verberne AJM and Owens NC. Cortical modulation of the cardiovascular system. Prog Neurobiol 54: 149-168, 1998.
22. Waldrop TG and Iwamoto GA. Neurons in the insular cortex are responsive to muscular contraction and have sympathetic and/or cardiac-related discharge. Soc Neurosci Abstr 20: 1370, 1994.
23. Waldrop TG, Eldridge FL, Iwamoto GA, and Mitchell JH. Central neural control of respiratory and circulation during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am Physiol. Soc., 1996, sect. 12, chapt. 9, p. 333-380.
24. Williamson JW, Olesen HL, Pott F, Mitchell JH, and Secher NH. Central command increases cardiac output during static exercise in humans. Acta Physiol Scand 156: 429-434, 1996.
25. Williamson JW, McColl R, Mathews D, Ginsburg M, and Mitchell JH. Activation of the insular cortex is affected by the intensity of exercise. J Appl Physiol 87: 1213-1219, 1999.
26. Williamson JW, McColl R, Mathews D, Raven PB, Mitchell JH, and Morgan WP. Hypnotic manipulation of effort sense during dynamic exercise: cardiovascular responses and brain activation. J Appl Physiol 90: 1392-1399, 2001.
27. Williamson JW, McColl R, Mathews D, Mitchell JH, Raven PB, and Morgan WP. Brain activation by central command during actual and imagined handgrip under hypnosis. J Appl Physiol 92: 1317-1324, 2002.
28. Woods RP, Cherry SR, and Mazziotta JC. Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 16: 620-633, 1992.
29. Zhang Z and Oppenheimer SM. Characterization, distribution and lateralization of baroreceptor-related neurons in the rat insular cortex. Brain Res 760: 243-250, 1997.
30. Zhang ZH and Oppenheimer SM. Baroreceptive and somatosensory convergent thalamic neurons project to the posterior insular cortex in the rat. Brain Res 861: 241-256, 2000.