Correlation between histopathological findings of the liver and IgA class antibodies to 2-oxo-acid dehydrogenase complex in primary biliary cirrhosis

Digestive Diseases and Sciences

Volumn 48, Issue 5, 2003, Pages 932-938

  Masuda, Jun Ichi ^a   Omagari, Katsuhisa ^a   Ohba, Kazuo ^a,b   Hazama, Hiroaki ^a   Kadokawa, Yoshiko ^a   Kinoshita, Hideki ^a   Hayashida, Kenji ^a   Hayashida, Kazuhiro ^c   Ishibashi, Hiromi ^d   Nakanuma, Yasuni ^b   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

Author keywords

2 oxo acid dehydrogenase complex; Immunoblotting anti mitochondrial antibody; Immunoglobulin A; Liver histology; Primary biliary cirrhosis

Indexed keywords

2 OXOACID DEHYDROGENASE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; MITOCHONDRION ANTIBODY; PYRUVATE DEHYDROGENASE;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LIVER BIOPSY; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL;

ADULT; AGED; AUTOANTIBODIES; BIOLOGICAL MARKERS; BIOPSY, NEEDLE; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; PYRUVATE DEHYDROGENASE COMPLEX; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 0037404329     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023055714208     Document Type: Article

References (27)

1. Kaplan MM: Primary biliary cirrhosis. N Engl J Med 335:1570-1580, 1996
2. Mackay IR, Gershwin ME: Pathogenesis of primary biliary cirrhosis. In Autoimmune Liver Diseases, 2nd ed. EL Krawitt, RH Wiesner, M Nishioka (eds). Amsterdam, Elsevier, 1998, pp 49-69
3. Heseltine L, Turner IB, Fussey SPM, Kelly PJ, James OFW, Yeaman SJ, Bassendine MF: Primary biliary cirrhosis. Quantitation of autoantibodies to purified mitochondrial enzymes and correlation with disease progression. Gastroenterology 99:1786-1792, 1990
4. Van Norstrand MD, Malinchoc M, Lindor KD, Therneau TM, Gershwin ME, Leung PSC, Dickson ER, Homburger HA: Quantitative measurement of autoantibodies to recombinant mitochondrial antigens in patients with primary biliary cirrhosis: relationship of levels of autoantibodies to disease progression. Hepatology 25:6-11, 1997
5. Jones DEJ: Autoantigens in primary biliary cirrhosis. J Clin Pathol 53:813-821, 2000
6. Invernizzi P, Podda M, Battezzati PM, Crosignani A, Zuin M, Hitchman E, Maggioni M, Meroni PL, Penner E, Wesierska-Gadek J: Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol 34:366-372, 2001
7. Joshi S, Cauch-Dudek K, Heathcote EJ, Lindor K, Jorgensen R, Klein R: Antimitochondrial antibody profiles: are they valid prognostic indicators in primary biliary cirrhosis? Am J Gastroenterol 97:999-1002, 2002
8. Kisand KE, Kisand KV, Karvonen A-L, Vuoristo M, Mattila J, Makinen J, Uibo R: antibodies to pyruvate dehydrogenase in primary biliary cirrhosis: correlation with histology. APMIS 106:884-892, 1998
9. Scheuer PJ, Lefkowitch JH: Liver Biopsy Interpretation, 6th ed. London, WB Saunders, 2000
10. Hazama H, Omagari K, Masuda J, Ohba K, Kinoshita H, Matsuo I, Isomoto HI, Mizuta Y: Automated enzymatic mitochondrial antibody assay for the diagnosis of primary biliary cirrhosis: applications of a routine diagnostic tool for the detection of antimitochondrial antibodies. J Gastroenterol Hepatol 17:316-323, 2002
11. Takemura M, Ohya K, Kojima K: Fundamental evaluation of MES ACUP-2 Test Mitochondrial M2. Jpn J Med Pharm Sci 46:809-816, 2001 (in Japanese)
12. Stanley CJ, Perham RN: Purification of 2-oxo acid dehydrogenase multienzyme complexes from ox heart by a new method. Biochem J 191:147-154, 1980
13. Kinoshita H, Omagari K, Matsuo I, Yamaguchi K, Ikuno N, Kohno S: Frequency of IgG, IgM, and IgA class autoantibodies against 2-oxo-acid dehydrogenase complex in 102 Japanese patients with primary biliary cirrhosis. Hepatol Res 15:163-171, 1999
14. Itoh S, Ichida T, Yoshida T, Hayakawa A, Uchida M, Tashiro-Itoh T, Matsuda Y, Ishihara K, Asakura H: Autoantibodies against a 210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis. J Gastroenterol Hepatol 13:257-265, 1998
15. Corpechot C, Benlian P, Barbu V, Chazouilleres O, Poupon RE, Poupon R: Apolipoprotein E polymorphism, a marker of disease severity in primary biliary cirrhosis? J Hepatol 35:324-328, 2001
16. Donaldson P, Agarwal K, Craggs A, Craig W, James O, Jones D: HLA and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility. Gut 48:397-402, 2001
17. Metcalf JV, Mitchison HC, Palmer JM, Jones DE, Bassendine MF, James OFW: Natural history of early primary biliary cirrhosis. Lancet 348:1399-1402, 1996
18. Nagura H, Sumi Y, Fukuda Y, Hasegawa H, Watanabe K, Brown WR: Studies on the relationships of IgA to human liver. IgA deposition in non-alcoholic liver diseases. Acta Pathol Jpn 39:363-372, 1989
19. Sugiura H, Nakanuma Y: Secretory component and immunoglobulins in the intrahepatic biliary tree and peribiliary gland in normal livers and hepatolithiasis. Gastroenterol Jpn 24:308-314, 1989
20. Nishio A, Van de Water J, Leung PSC, Joplin R, Neuberger JM, Lake J, Bjorkland A, Totterman TH, Peters M, Worman HJ, Ansari AA, Coppel RL, Gershwin ME: Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis. Hepatology 25:1085-1089, 1997
21. Floreani A, Baragiotta A, Pizzuti D, Martines D, Cecchetto A, Chiarelli S: Mucosal IgA defect in primary biliary cirrhosis. Am J Gastroenterol 97:508-510, 2002
22. Fukushima N, Nalbandian G, Van de Water J, White K, Ansari AA, Leung P, Kenny T, Kamita SG, Hammock BD, Coppel RL, Stevenson F, Ishibashi H, Gershwin ME: Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with primary biliary cirrhosis. Hepatology 36:1383-1392, 2002
23. Joplin RE, Wallace LL, Lindsay JG, Palmer JM, Yeaman SJ, Neuberger JM: The human biliary epithelial cell plasma membrane antigen in primary biliary cirrhosis: pyruvate dehydrogenase X? Gastroenterology 113:1727-1733, 1997
24. Nakanuma Y, Tsuneyama K, Harada K: Pathology and pathogenesis of intrahepatic bile duct loss. J Hepatobiliary Pancreat Surg 8:303-315, 2001
25. Nakajima M, Shimizu H, Miyazaki A, Watanabe S, Kitami N, Sato N: Detection of IgA, IgM, and IgG subclasses of anti-M2 antibody by immunoblotting in autoimmune cholangitis: Is autoimmune cholangitis an early stage of primary biliary cirrhosis? J Gastroenterol 34:607-612, 1999
26. Masuda J, Omagari K, Miyakawa H, Hazama H, Ohba K, Kinoshita H, Matsuo I, Isomoto H, Murata I, Kohno S: Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis. Autoimmunity 35:135-141, 2002
27. Inoue K, Hirohara J, Nakano T, Seki T, Sasaki H, Higuchi K, Ohta Y, Onji M, Muto Y, Moriwaki H: Prediction of prognosis of primary biliary cirrhosis in Japan. Liver 15:70-77, 1995