The catalytic mechanism of Drosophila alcohol dehydrogenase: Evidence for a proton relay modulated by the coupled ionization of the active site lysine/tyrosine pair and a NAD+ ribose OH switch

Proteins: Structure, Function and Genetics

Volumn 51, Issue 2, 2003, Pages 289-298

  Koumanov, Assen ^a   Benach, Jordi ^a,c   Atrian, Silvia ^b   Gonzàlez Duarte, Roser ^b   Karshikoff, Andrey ^a   Ladenstein, Rudolf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF BARCELONA   (Spain)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Alcohol dehydrogenase; Catalytic mechanism; Electrostatic interactions; Ionization; Proton relay

Indexed keywords

ALCOHOL DEHYDROGENASE; DROSOPHILA ALCOHOL DEHYDROGENASE; HYDROGEN; LYSINE; RIBOSE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COENZYME; CONTROLLED STUDY; CORRELATION ANALYSIS; DROSOPHILA; ELECTRICITY; ENZYME DEGRADATION; HYDROGEN BOND; HYDROGENATION; IONIZATION; NONHUMAN; PH; POLARIZATION; PRIORITY JOURNAL; PROTON TRANSPORT; THEORETICAL STUDY; TITRIMETRY;

ALCOHOL DEHYDROGENASE; ANIMALS; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; DROSOPHILA; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROXIDES; LYSINE; MODELS, CHEMICAL; MODELS, MOLECULAR; NAD; OXIDATION-REDUCTION; PROTEIN BINDING; PROTONS; SUBSTRATE SPECIFICITY; TYROSINE; WATER;

SCAPTODROSOPHILA LEBANONENSIS;

EID: 0037402095     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10354     Document Type: Article

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