26-Week repeated oral dose toxicity study of the new quinolone antibacterial DW-116 in Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 41, Issue 5, 2003, Pages 637-645

  Kim, J C ^a   Shin, D H ^a   Ahn, T H ^a   Kang, S S ^a   Song, S W ^b   Han, J ^c   Kim, C Y ^c   Ha, C S ^c   Chung, M K ^c  

^a Chonnam National University   (South Korea)

^b Chemon Inc   (South Korea)

^c Korea Institute of Toxicology   (South Korea)

Author keywords

Fluoroquinolones; NOAEL; Rats; Repeated oral dose; Subchronic toxicity

Indexed keywords

ANTIINFECTIVE AGENT; FANDOFLOXACIN; QUINOLONE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BILIRUBIN BLOOD LEVEL; BIOCHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; FLUID INTAKE; FOOD INTAKE; HEMATOLOGY; HISTOPATHOLOGY; LEUKOCYTE; LIVER WEIGHT; LYMPHOCYTE COUNT; MALE; MORTALITY; NONHUMAN; OPHTHALMOSCOPY; RAT; RAT STRAIN; SALIVATION; TOXICITY TESTING; URINALYSIS;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ANTI-INFECTIVE AGENTS; BILIRUBIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROQUINOLONES; LEUKOCYTE COUNT; LIVER; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PIPERAZINES; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS;

EID: 0037401218     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00325-3     Document Type: Article

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