Pharmacokinetics of 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1- piperazinyl)1,4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride (DW- 116), a new quinolone antibiotic in rats

Journal of Pharmaceutical Sciences

Volumn 86, Issue 5, 1997, Pages 550-553

  Yu, In Lim ^a   Chung, Suk Jae ^a   Lee, Min Hwa ^a   Shim, Chang Koo ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; FANDOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RUFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERY CATHETERIZATION; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG STRUCTURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RAT; VEIN CATHETERIZATION;

EID: 0031000212     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js960464o     Document Type: Article

References (9)

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5. Gibaldi, M.; Perrier, D. In Pharmacokinetics; Marcel Dekker: New York, 1982; pp 409-417.
6. Yu, I.-L. Pharmacokinetic Studies of a New Quinolone, DW-116 [1-(5-Fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4- oxoquinolone-3-carboxylic acid hydrochloride], in Wistar Rats, Master's Thesis, Seoul National University, Seoul, 1995.
7. Wagner, J. G. In Pharmacokinetics for the Pharmaceutical Scientists; Technomic Publication: Lancaster, PA, 1993; pp 45-62.
8. Siefert, R. M.; Maruhn, D.; Maul, W.; Foster, D.; Ritter, W. Drug Res. 1986, 36, 1496-1502.
9. Karabault, N.; Drusano, G. L. In Quinolone Antimicrobial Agents; Hooper, D. C.; Wolfson, J. S., Eds., American Society for Microbiology: Washington D. C., 1993; pp 195-223.