Older patients with colon cancer: Is adjuvant chemotherapy safe and effective?

Journal of the American Geriatrics Society

Volumn 51, Issue 4, 2003, Pages 567-569

  Arora, Amit ^a   Potter, Jane ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; LEVAMISOLE;

AGED; AGING; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CANCER RECURRENCE; CLINICAL TRIAL; COLON CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HIGH RISK PATIENT; HUMAN; LEUKOPENIA; NAUSEA; NOTE; POSTOPERATIVE CARE; RANDOMIZED CONTROLLED TRIAL; STOMATITIS; VOMITING;

ADENOCARCINOMA; AGED; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; MALE; RANDOMIZED CONTROLLED TRIALS;

EID: 0037392146     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2003.51169.x     Document Type: Note

References (15)

1. Greenlee RT, Hill-Marmon MB, Murray T et al. Cancer statistic. Cancer J Clin 2001;51:15-36.
2. Greenfield S, Blanco DM, Elashoff RM et al. Patterns of care related to age of breast cancer patients. JAMA 1986;257:2766-2770.
3. Mor V, Masterson-Allen S, Goldberg RJ et al. Relationship between age at diagnosis and treatments received by cancer patients. J Am Geriatr Soc 1985; 33:585-589.
4. Laurie JA, Moertel CG, Fleming TR et al. Surgical adjuvant therapy of large bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. J Clin Oncol 1989;7:1447-1456.
5. Moertel CG, Fleming TR, Macdonald JS et al. Levamisole and fluorouracil for adjuvant therapy of resected colon cancer. N Engl J Med 1990;322:352-358.
6. Connell MJ, Laurie JA, Kahn M et al. Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high risk colon cancer. J Clin Oncol 1998;16:295-300.
7. Francini G, Petrioli R, Lorenzini L et al. Folinic acid and 5 fluorouracil for adjuvant chemotherapy in colon cancer. Gastroenterology 1994;106:899-906.
8. Sundararajan V, Mitra N, Jacobson J et al. Survival associated with fluorouracil-based adjuvant chemotherapy among elderly patients with node positive colon cancer. Ann Intern Med 2002;136:349-357.
9. Popescu RA, Norman A, Ross PJ et al. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999;17: 2412-2418.
10. Brower M, Asbury R, Kramer Z et al. Adjuvant chemotherapy for colorectal cancer in the elderly; population based experience [abstract]. Prog Proc AM Soc Clin Oncol 1993;12:195.
11. Tropman SE, Hatzell T, Paskett E et al. Colon cancer treatment in rural North and South Carolina. Cancer Detect Prev 1999;23:428-434.
12. Lichtman SM, Skirvin JA. Pharmacology of antineoplastic agents in older cancer patients. Oncology 2000;14:1743-1755.
13. Litchman SM, Boyer KLGI. Cancer in the elderly. In: Whitaker K, Balducci L (Guest, eds.). Clinics in Geriatric Medicine. Cancer in the Elderly. Part II. Philadelphia: W.B. Saunders Co., 1997, pp. 307-326.
14. Mahoney T, Kuo YH, Topilow A et al. Stage III colon cancers: Why adjuvant chemotherapy is not offered to elderly patients. Arch Surg 2000;135:182-185.
15. Kane RL, Ouslander JG, Abrass IB. Essentials of Clinical Geriatrics, 4th Ed. New York: McGraw-Hill, 1999, pp. 19-42.