Effects of the SOD mimetic, M40403, on prostaglandin production in an in vivo model of ischemia and reperfusion in rat heart

Inflammation Research

Volumn 52, Issue SUPPL.1, 2003, Pages

  Marzocca, C ^a   Vannacci, A ^a   Cuzzocrea, S ^a   Salvemini, D ^b,c   Mannaioni, P F ^a   Masini, E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c MetaPhore Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANGANESEDICHLORO(3,10,13,20,26 PENTAAZATETRACYCLO[20.3.1.0(4,9).0(14,19)] 1(26),22(23),24 HEXACOSATRIENE); MYELOPEROXIDASE; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART MUSCLE ISCHEMIA; INFLAMMATION; ISCHEMIC HEART DISEASE; MALE; NEUTROPHIL; NONHUMAN; RAT; REPERFUSION INJURY; TISSUE INJURY;

ANIMALS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; ORGANOMETALLIC COMPOUNDS; PEROXIDASE; PROSTAGLANDINS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 0037391528     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110300037     Document Type: Conference Paper

References (8)

1. Pairet M, van Ryn J and Distel M. Overview of COX-2 in inflammation: from the biology to the clinic. In: Inducible enzymes in the Inflammatory Response. D. A. Willoughby and Tomlinson A. Eds. Birkhäuser Verlag, Basel, Boston, Berlin, 1999, pp. 1-30.
2. Chen Z, Oberley TD, Ho Y, Chua CC, Siu B, Hamdy RC et al. Over-expression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury. Free Radic Biol Med 2000; 29: 589-96.
3. Salvemini D, Wang ZQ, Zweier JL, Samouilov A, Macarthur H, Misko TP et al. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science 1999; 286: 304-6.
4. Masini E, Cuzzocrea S, Mazzon E, Marzocca C, Mannaioni PF and Salvemini D. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol 2002; 136: 905-17.
5. Bani D, Masini E, Bello MG, Bigazzi M and Bani Sacchi T. Relax-in protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am J Pathol, 1998; 152: 1367-76.
6. Pradelles P, Grassi J and Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholinesterase as label: an alternative to radioimmunoassay. Anal Chem 1985; 57: 1170-3.
7. Mitchell JA, Belvisi M, Akerasereenont P, Robbins R, Kwon OJ, Croxtall J et al. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexametasone. Br J Pharmacol 1994; 113: 1008-114.
8. Patrono C, Patrignani P and Garcia Rodriguez LA. Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs. J Clin Invest 2001; 108: 7-13.