From anticholinesterase toxicity to Alzheimer's disease: Important interactions of cholinergic and NMDA receptor systems

Toxicological Sciences

Volumn 72, Issue 2, 2003, Pages 185-187

  Popke, E Jon ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ATROPINE; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; DICHLORVOS; DIZOCILPINE; ETHYLCHOLINE MUSTARD AZIRIDINIUM; MECAMYLAMINE; METHOMYL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NT 1505; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CENTRAL NERVOUS SYSTEM; CHOLINERGIC STIMULATION; COGNITIVE DEFECT; DISEASE COURSE; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; LETHALITY; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REVIEW; SEIZURE;

ALZHEIMER DISEASE; ANIMALS; CHOLINESTERASE INHIBITORS; HUMANS; MICE; RECEPTORS, CHOLINERGIC; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0037390908     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg050     Document Type: Review

References (15)

1. Aizenman, E., Tang, L.H., and Reynolds, I.J. (1991). Effects of nicotinic agonists on the NMDA receptor. Brain Res. 551, 355-357.
2. Bachurin, S., Tkachenko, S., Baskin, I., Lermontova, N., Mukhina, T., Petrova, L., Ustinov, A., Proshin, A., Grigoriev, V., Lukoyanov, N., Palyulin, V., and Zefirov, N. (2001), Neuroprotective and cognition-enhancing properties of MK-801 flexible analogs. Structure-activity relationships. Ann. N.Y. Acad. Sci. 939, 219-236.
3. Bi, H., and Sze, C. I. (2002). N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease. J. Neurol. Sci. 200, 11-18.
4. Bi, X., Gall, C. M., Zhou, J., and Lynch, G. (2002). Uptake and pathogenic effects of amyloid β peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 114, 827-840.
5. Court, J.A., Piggott, M.A., and Perry, E.K. (1990). Nicotine reduces binding of [3H]MK-801 to brain membranes, but not via the stimulation of high-affinity nicotinic receptors. Brain Res. 524(2), 319-321.
6. Greenamyre, J.T., Penney, J.B., D'Amato, C.J., and Young, A.B. (1987). Dementia of the Alzheimer's type: changes in hippocampal L-[3H] glutamate binding. J. Neurochem. 48, 543-551.
7. Harkany, T., Abraham, I., Timmerman, W., Laskay, G., Sasvari, M., Konya, C., Sebens, J. B., Korf, J., Nyakas, C., Zarandi, M., Soos, K., Penke, B., and Luiten, P. G. M. (2000). β-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in the rat nucleus basalis. Eur. J. Neurosci. 12, 2735-2745.
8. Harkany, T., Mulder, J., Sasvari, M., Abraham, I., Konya, C., Zarandi, M., Penke, B., Luiten, P. G., and Nyakas, C. (1999). N-methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against β-amyloid neurotoxicity. Neurobiol. Dis. 6, 109-121.
9. Hynd, M. R., Scott, H. L., and Dodd, P. R. (2001). Glutamate NMDA receptor NR1 subunit mRNA expression in Alzheimer's disease. J. Neurochem. 78, 175-182.
10. Levin, E. D., Bettegowda, C., Weaver, T. and Channelle, C. (1998). Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial arm maze. Pharmacol. Biochem. Behav. 61, 335-340.
11. Olney, J. W., Wozinak, D. F., and Farber, N. B. (1997). Excitotoxic neurode-generation in Alzheimer's disease: new hypothesis and new therapeutic strategies. Arch. Neurol. 54, 124-1240.
12. Shoaib, M., Schindler, C. W., Goldberg, S. R., and Pauly, J. R. (1997). Behavioral and biochemical adaptations to nicotine in rats: influence of MK-801, an NMDA receptor antagonist. Psychopharmacologia 134, 121-130.
13. Sze, S. I., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M., and Martin, L. J. (2001). N-methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease. J. Neurol. Sci. 182, 151-159.
14. Sziraki, I., Sershen, H., Benuck, M., Hashim, A, and Lajtha, A. (1998). Receptor systems participating in nicotine-specific effects. Neruochem. Int. 33, 445-457.
15. Terry, A. V., Risbrough, V. B., Buccafusco, J. J., and Menzaghi, F. (2002). Effects of (±)-4-{[2-(1-methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys. J. Pharmacol. Exp. Ther. 301, 284-292.