Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: Evidence from a controlled trial involving adults

Clinical Infectious Diseases

Volumn 36, Issue 7, 2003, Pages 850-857

  Scheifele, David W ^a,e   Duval, Bernard ^b   Russell, Margaret L ^c   Warrington, Richard ^d   DeSerres, Gaston ^b   Skowronski, Danuta M ^a   Dionne, Marc ^b   Kellner, James ^c   Davies, Dele ^c   MacDonald, Judy ^c  

^a Can Assoc Immunization Res/Eval   (Canada)

^b Can Assoc Immunization Res Eval   (Canada)

^c Can Assoc Immunization Res/Eval   (Canada)

^d Can Assoc Immunization Res Eval   (Canada)

^e BC CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INACTIVATED VACCINE; INFLUENZA VACCINE; PLACEBO;

ADULT; ARM MOVEMENT; ARTHRALGIA; ARTICLE; CHILL; CLINICAL TRIAL; COMMON COLD; CONFIDENCE INTERVAL; CONJUNCTIVAL HYPEREMIA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; DYSPHAGIA; DYSPNEA; EDEMA; ERYTHEMA; EYE DISEASE; EYELID EDEMA; FATIGUE; FEMALE; FEVER; FUNCTIONAL DISEASE; HEADACHE; HOARSENESS; HUMAN; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS; LIP DISEASE; MAJOR CLINICAL STUDY; MALAISE; MALE; MOUTH DISEASE; MULTICENTER STUDY; MYALGIA; NAUSEA; OCULAR PRURITUS; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RISK ASSESSMENT; SLEEP DISORDER; SORE THROAT; THORAX PAIN; VISUAL IMPAIRMENT; VOMITING; WHEEZING;

ADULT; AGE DISTRIBUTION; COUGH; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EYE DISEASES; FEMALE; HOARSENESS; HUMANS; INFLUENZA VACCINES; MALE; MIDDLE AGED; VACCINES, INACTIVATED;

EID: 0037385128     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/368189     Document Type: Article

References (15)

1. National Advisory Committee on Immunization. Supplementary statement for the 2001-2002 season: influenza vaccination of persons who experienced oculorespiratory syndrome following previous influenza vaccination. Can Commun Dis Rep 2001; 27:1-7.
2. Boulianne N, De Serres G, Duval B, Shadmani R, Rochette L. Clinical manifestations and incidence of oculorespiratory syndrome following influenza vaccination - Quebec, 2000. Can Commun Dis Rep 2001; 27:85-90.
3. Greenland S, Robins JM. Conceptual problems in the definition and interpretation of attributable fraction. Am J Epidemiol 1988; 128:1185-97.
4. Margolis KL, Nichol KL, Poland GA, Pluhar RE. Frequency of adverse reactions to influenza vaccine in the elderly: a randomized, placebo-controlled trial. JAMA 1990; 264:1139-41.
5. Nichol KL, Margolis KL, Lind A, et al. Side effects associated with influenza vaccination in healthy, working adults: a randomized, placebo-controlled trial. Arch Intern Med 1996; 156:1546-50.
6. Allsup SJ, Gosney M, Regan M, Haycox A, Fear S, Johnstone FC. Side effects of influenza vaccination in healthy older people: a randomised single-blind placebo-controlled trial. Gerontology 2001; 47:311-4.
7. Govaert TME, Dinant GJ, Aretz K, Masurel N, Sprenger MJW, Knottnerus JA. Adverse reactions to influenza vaccine in elderly people: randomized double blind placebo controlled trial. BMJ 1993; 307:988-90.
8. Scheifele DW, Bjornson G, Johnston J. Evaluation of adverse events after influenza vaccination in hospital personnel. CMAJ 1990; 142:127-30.
9. al-Mazrou A, Scheifele DW, Soong T, Bjornson G. Comparison of adverse reactions to whole-virion and split-virion influenza vaccines in hospital personnel. CMAJ 1991; 145:213-8.
10. Cate TR, Couch RB, Parker D, Baxter B. Reactogenicity, immunogenicity and antibody persistence in adults given inactivated influenza vaccines - 1978. Rev Infect Dis 1983; 5:737-47.
11. Fleiss JL. The design and analysis of clinical experiments. New York: John Wiley and Sons, 1986:263-90.
12. DeSerres G, Boulianne N, Duval B, et al. Oculo-respiratory syndrome after vaccination: evidence for occurrence with more than one influenza vaccine. Vaccine (in press).
13. Coplan P, Chiacchierini L, Nikas A, et al. Development and evaluation of a standardized questionnaire for identifying adverse events in vaccine clinical trials. Pharmacoepidemiol Drug Safety 2000; 9:457-71.
14. Skowronski DM, De Serres G, Warrington R, et al. Oculo-respiratory syndrome following influenza vaccine: recurrence risk with a re-formulated vaccine for 2001-2002 (abstract S42). In: Program and abstracts of the 5th Annual Conference on Vaccine Research (Baltimore). Bethesda, MD: National Foundation for Infectious Diseases, 2002:11.
15. Skowronski DM, Strauss B, Kendall P, Duval B, DeSerres G. Low risk of recurrence of oculorespiratorv syndrome following influenza revaccination. CMAJ 2002; 167:853-8.