Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation

Clinical Pharmacology and Therapeutics

Volumn 73, Issue 4, 2003, Pages 330-337

  Heikkinen, Tuija ^a,b   Ekblad, Ulla ^a   Palo, Pertti ^a   Laine, Kari ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; FLUOXETINE; NORFLUOXETINE;

ADULT; ARTICLE; BREAST MILK; CHILD GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DEPRESSION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG METABOLISM; DRUG MILK LEVEL; FEMALE; HUMAN; LACTATION; NERVOUS SYSTEM DEVELOPMENT; PANIC; PREGNANCY; PRIORITY JOURNAL; TREATMENT FAILURE;

ADULT; CHILD DEVELOPMENT; FEMALE; FLUOXETINE; HUMANS; INFANT, NEWBORN; LACTATION; MALE; MILK, HUMAN; PREGNANCY; PROSPECTIVE STUDIES;

EID: 0037384041     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(02)17634-X     Document Type: Article

References (36)

1. Stokes P, Holtz A. Fluoxetine tenth anniversary update: the progress continues. Clin Ther 1997;19:1135-250.
2. Fjordside L, Jeppesen U, Eap CB, Powell K, Bauman P, Brosen K. The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine. Pharmacogenetics 1999;9:55-60.
3. Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS. (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos 2000;28:1187-91.
4. Ring BJ, Eckstein JA, Gillespie JS, Binkley SN, Vandenbranden M, Wrighton SA. Identification of the human cytochromes p450 responsible for in vitro formation of r- and s-norfluoxetine. J Pharmacol Exp Ther 2001;297:1044-50.
5. Cusack B, Nelson A, Richelson E. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology 1994;114:559-65.
6. Renshaw PF, Guimaraes AR, Fava M, et al. Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration. Am J Psychiatry 1992;149:1592-4.
7. Eap CP, Bondolfi G, Zullino D, Savary-Cosendai L, Powell-Golay K, Kosel M, et al. Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers. J Clin Psychopharmacol 2001;21:330-4.
8. Pastuszak A, Schick-Boschetto B, Zuber C, Feldkamp M, Pinelli M, Sihn S, et al. Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac). JAMA 1993;269:2246-8.
9. Kulin NA, Pastuszak A, Sage SR, Schick-Boschetto B, Spivey G, Feldkamp M, et al. Pregnancy outcome following maternal use of the new selective serotonin re-uptake inhibitors. JAMA 1998;279:609-10.
10. Cohen LS, Heller VL, Bailey JW, Grush L, Ablon JS, Bouffard SM, et al. Birth outcomes following prenatal exposure to fluoxetine. Biol Psychiatry 2000;48:996-1000.
11. Nulman I, Rovet J, Stewart DE, Wolpin J, Gardner HA, Theis JG, et al. Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 1997;336:258-62.
12. Spencer MJ. Fluoxetine hydrochloride (Prozac) toxicity in a neonate. Pediatrics 1993;92:721-2.
13. Mhanna MJ, Bennet JB, Izatt SD. Potential fluoxetine chloride (Prozac) toxicity in a newborn. Pediatrics 1997;100:158-9.
14. Mohan CG, Moore JJ. Fluoxetine toxicity in a preterm infant. J Perinatol 2000;20:445-6.
15. Taddio A, Ito S, Koren G. Excretion of fluoxetine and its metabolite, norfluoxetine, in human breast milk. J Clin Pharmacol 1996;36:42-7.
16. Yoshida K, Smith B, Craggs M, Kumar RC. Fluoxetine in breast-milk and developmental outcome of breast-fed infants. Br J Psychiatry 1998;172:175-8.
17. Kristensen JH, Ilett KF, Hackett LP, Yapp P, Paich M, Begg EJ. Distribution and excretion of fluoxetine and norfluoxetine in human milk. Br J Clin Pharmacol 1999;48:521-7.
18. Hendrick V, Stowe ZN, Altshuler LL, Mintz J, Hwang S, Hostetter A, et al. Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. Biol Psychiatry 2001;50:775-82.
19. Chambers CD, Anderson PO, Thomas RG, Dick LM, Felix RJ, Johnson KA, et al. Weight gain in infants breastfed by mothers who take fluoxetine. Pediatrics 1999;104:e61.
20. Gesell AJ, Amatruda CS. Developmental diagnosis. 2nd ed. New York: Paul B. Hoeber; 1941.
21. Kelly MW, Perry PJ, Holstad SG, Garvey MJ. Serum fluoxetine and norfluoxetine concentrations and antidepressant response. Ther Drug Monit 1989;11:165-70.
22. International Dairy Federation. Standard 1D:1996. Milk: determination of fat content - gravimetric method (reference method). Brussels: International Dairy Federation; 1996.
23. Atkinson HC, Begg EJ, Darlow BA. Drugs in human milk: clinical pharmacokinetic considerations. Clin Pharmacokinet 1988;14:217.
24. Lundmark J, Reis M, Bengtsson F. Serum concentrations of fluoxetine in the clinical treatment setting. Ther Drug Monit 2001;23:139-47.
25. Wadelius M, Darj E, Frenne G, Rane A. Induction of CYP2D6 in pregnancy. Clin Pharmacol Ther 1997;26:400-7.
26. Heikkinen T, Ekblad U, Kero P, Ekblad S, Laine K. Citalopram in pregnancy and lactation. Clin Pharmacol Ther 2002;72:184-91.
27. Treluyr JM, Jacqz-Aigrain EJ, Alvarez F, Cresteil T. Expression of CYP2D6 in developing human liver. Eur J Biochem 1991;202:583-8.
28. Hakkola J, Pasanen M, Purkunen R, Saarikoski S, Pelkonen O, Maenpaa J, et al. Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver. Biochem Pharmacol 1994;48:59-64.
29. Shimada T, Yamazaki H, Mimura M, Wakamiya N, Ueng YF, Guegerich FP, et al. Characterisation of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human foetal livers and adult lungs. Drug Metab Dispos 1996;24:515-22.
30. Cresteil T. Onset of xenobiotic metabolism in children: toxicological implications. Food Addit Contam 1998;15:45-51.
31. Gow PJ, Ghabrial H, Smallwood RA, Morgan DJ, Ching MS. Neonatal hepatic drug elimination. Pharmacol Toxicol 2000;88:3-15.
32. Mannering GJ. Drug metabolism in the newborn. Fed Proc 1985;44:2302-8.
33. Atkinson HC, Begg EJ, Darlow BA. Drugs in human milk. Clinical pharmacokinetic considerations. Clin Pharmacokinet 1988;14:217-40.
34. Duffull SB, Begg EJ, Ilett KF. Fluoxetine distribution in human milk [letter]. Br J Clin Pharmacol 1996;36:1078.
35. Ito S. Drug therapy for breast-feeding women. N Engl J Med 2000;342:118-26.
36. Rambono J, Kristensen JH, Hackett LP, Paech M, Kohan R, Ilett KF. Citalopram and desmethylcitalopram in human milk; distribution, excretion and effects in breast fed infants. Br J Clin Pharmacol 2000;50:263-8.