Macroprolactin - A cause of pseudohyperprolactinaemia

Hong Kong Medical Journal

Volumn 9, Issue 2, 2003, Pages 119-121

  Yuen, Y P ^a   Lai, J P S ^b   Au, K M ^a   Chan, A Y W ^a   Mak, T W L ^b  

^a PRINCESS MARGARET HOSPITAL   (Hong Kong)

^b TUEN MUN HOSPITAL   (Hong Kong)

Author keywords

Hyperprolactinemia; Immunoassay; Polyethylene glycol; Prolactin

Indexed keywords

IMMUNOGLOBULIN G; MACROGOL; MACROPROLACTIN; PROLACTIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CHILD; CLINICAL FEATURE; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HYPERPROLACTINEMIA; HYPOPHYSIS TUMOR; PITUITARY INCIDENTALOMA; PROLACTIN BLOOD LEVEL; PSEUDOHYPERPROLACTINAEMIA;

ADULT; ANDROGENS; CHILD; FEMALE; HUMANS; HYPERPROLACTINEMIA; MAGNETIC RESONANCE IMAGING; PITUITARY DISEASES; PITUITARY GLAND; PROLACTIN; PUBERTY;

EID: 0037383866     PISSN: 10242708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Smith CR, Norman MR. Prolactin and growth hormone: molecular heterogeneity and measurement in serum. Ann Clin Biochem 1990; 27:542-50.
2. Leite V, Cosby H, Sobrinho LG, Fresnoza MA, Santos MA, Friesen HG. Characterization of big, big prolactin in patients with hyperprolactinaemia. Clin Endocrinol (Oxf) 1992;37:365-72.
3. Bonhoff A, Vuille JC, Gomez F, Gellersen B. Identification of macroprolactin in a patient with asymptomatic hyperprolactinemia as a stable PRL-IgG complex. Exp Clin Endocrinol Diabetes 1995;103: 252-5.
4. John R, McDowell IF, Scanlon MF, Ellis AR. Macroprolactin reactivities in prolactin assays: an issue for clinical laboratories and equipment manufacturers. Clin Chem 2000;46:884-5.
5. Fahie-Wilson MN. Detection of macroprolactin causing hyperprolactinemia in commercial assays for prolactin. Clin Chem 2000;46: 2022-3.
6. Fahie-Wilson MN, Soule SG. Macroprolactinaemia: contribution to hyperprolactinaemia in a district general hospital and evaluation of a screening test based on precipitation with polyethylene glycol. Ann Clin Biochem 1997;34:252-8.
7. Vieira JG, Tachibana TT, Obara LH, Maciel RM. Extensive experience and validation of polyethylene glycol precipitation as a screening method for macroprolactinemia. Clin Chem 1998;44:1758-9.
8. Fahie-Wilson M, Brunsden P, Surrey J, Everitt A. Macroprolacin and the Roche Elecsys prolactin assay: characteristics of the reaction and detection by precipitation with polyethylene glycol. Clin Chem 2000; 46:1993-5.
9. Leslie H, Courtney CH, Bell PM, et al. Laboratory and clinical experience in 55 patients with macroprolactinemia identified by a simple polyethylene glycol precipitation method. J Clin Endocrinol Metab 2001;86:2743-6.
10. Sanchez-Eixeres MR, Mauri M, Alfayate R, et al. Prevalence of macroprolactin detected by Elecsys 2010. Horm Res 2001;56:87-92.
11. Bjoro T, Morkrid L, Wergeland R, et al. Frequency of hyperprolactinaemia due to large molecular weight prolactin (150-170 kD PRL). Scand J Clin Lab Invest 1995;55:139-47.
12. Olukoga AO, Kane JW. Macroprolactinaemia: validation and application of the polyethylene glycol precipitation test and clinical characterization of the condition. Clin Endocrinol (Oxf) 1999;51: 119-26.
13. Schneider W, Marcovitz S, Al-Shammari S, Yago S, Chevalier S. Reactivity of macroprolactin in common automated immunoassays. Clin Biochem 2001;34:469-73.
14. Olukoga AO, Dornan TL, Kane JW. Three cases of macroprolactinaemia. J R Soc Med 1999;92:342-4.
15. Heaney AP. Laing I, Walton L, Seif MW, Beardwell CG, Davis JR. Misleading hyperprolactinaemia in pregnancy. Lancet 1999;353:720.
16. Fideleff HL, Ruibal G, Boquete H, Pujol A, Sequera A, Sobrado P. Macroprolactinemia in childhood and adolescence: a cause of asymptomatic hyperprolactinemia. Horm Res 2000;53:16-9.
17. Cattaneo FA, Fahie-Wilson MN. Concomitant occurrence of macroprolactin, exercise-induced amenorrhea, and a pituitary lesion: a diagnostic pitfall. Case report. J Neurosurg 2001;95:334-7.
18. Jackson RD, Wortsman J, Malarkey WB. Macroprolactinemia presenting like a pituitary tumor. Am J Med 1985;78:346-50.
19. Glezer A, D'Alva CB, Salgado LR, et al. Pitfalls in pituitary diagnosis: peculiarities of three cases. Clin Endocrinol (Oxf) 2002;57:135-9.