Potential end points of treatment after acute brain injury: Should we be using monitors of metabolism?

Current Opinion in Critical Care

Volumn 9, Issue 2, 2003, Pages 83-85

  Andrews, Peter J D ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCEROL; LACTIC ACID; PYRUVIC ACID;

AEROBIC METABOLISM; BIOLOGICAL MONITORING; BLOOD OXYGENATION; BLOOD PRESSURE REGULATION; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CENTRAL VENOUS PRESSURE; DISEASE SEVERITY; EDITORIAL; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; MEDICAL ASSESSMENT; MICRODIALYSIS; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; SUBARACHNOID HEMORRHAGE;

ACUTE DISEASE; BRAIN; BRAIN INJURIES; EXCITATORY AMINO ACIDS; HUMANS; INTENSIVE CARE; ISCHEMIA; MICRODIALYSIS; MONITORING, PHYSIOLOGIC; OXYGEN; TREATMENT OUTCOME;

EID: 0037383665     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-200304000-00001     Document Type: Editorial

References (17)

1. Andrews PJ, Sleeman DH, Statham PF, et al.: Predicting recovery in patients suffering from traumatic brain injury by using admission variables and physiological data: a comparison between decision tree analysis and logistic regression. J Neurosurg 2002, 97:326-336.
2. Robertson CS, Valadka AB, Hannay HJ, et al.: Prevention of secondary ischemic insults after severe head injury. Crit Care Med 1999, 27:2086-2095.
3. The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care: Hypotension. J Neurotrauma 2000, 17:591-595.
4. The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care: Critical pathway for the treatment of established intracranial hypertension. J Neurotrauma 2000, 17:537-538.
5. The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care: Use of barbiturates in the control of intracranial hypertension. J Neurotrauma 2000, 17:527-530.
6. The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care: Guidelines for cerebral perfusion pressure. J Neurotrauma 2000, 17:507-511.
7. Choi SC, Clifton GL, Marmarou A, et al.: Misclassification and treatment effect on primary outcome measures in clinical trials of severe neurotrauma. J Neurotrauma 2002, 19:17-22.
8. Dickinson K, Bunn F, Wentz R, et al.: Size and quality of randomised controlled trials in head injury: review of published studies. BMJ 2000, 320:1308-1311.
9. Roberts I, Schierhout G, Alderson P: Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review. J Neurol Neurosurg Psychiatry 1998, 65:729-733.
10. Clausen T, Zauner A, Levasseur JE, et al.: Induced mitochondrial failure in the feline brain: implications for understanding acute post-traumatic metabolic events. Brain Res 2001, 908:35-48.
11. Verweij BH, Muizelaar JP, Vinas FC, et al.: Impaired cerebral mitochondrial function after traumatic brain injury in humans. J Neurosurg 2000, 93:815-820.
12. Gopinath SP, Valadka AB, Uzura M, et al.: Comparison of jugular venous oxygen saturation and brain tissue Po2 as monitors of cerebral ischemia after head injury. Crit Care Med 1999, 27:2337-2345.
13. Gupta AK, Hutchinson PJ, Fryer T, et al.: Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method. J Neurosurg 2002, 96:263-268.
14. Valadka AB, Hlatky R, Furuya Y, et al.: Brain tissue PO2: correlation with cerebral blood flow. Acta Neurochir Suppl 2002, 81:299-301.
15. Macmillan CS, Andrews PJ, Easton VJ: Increased jugular bulb saturation is associated with poor outcome in traumatic brain injury. J Neurol Neurosurg Psychiatry 2001, 70:101-104.
16. Macmillan CS, Wild JM, Wardlaw JM, et al.: Traumatic brain injuries and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic." A primary study and review of the literature. Acta Neurochir (Wien) 2002, 144:853-862.
17. Hutchinson PJ, Gupta AK, Fryer TF, et al.: Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study. J Cereb Blood Flow Metab 2002, 22:735-745.