Forced detachment of the CD2-CD58 complex

Biophysical Journal

Volumn 84, Issue 4, 2003, Pages 2223-2233

  Bayas, M V ^a   Schulten, K ^a,b   Leckband, D ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b University of Illinois at Urbana Champaign   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL ADHESION; EQUILIBRIUM CONSTANT; FORCE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMULATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; TENSILE STRENGTH;

EID: 0037380955     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(03)75028-0     Document Type: Article

References (26)

1. Arulanandam, A. R. N., J. M. Withka, D. F. Wyss, G. Wagner, A. Kister, P. Pallai, M. A. Recny, and E. L. Reinherz. 1993. The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC′C″ face of the human CD2 adhesion domain. Proc. Natl. Acad. Sci. USA. 90:11613-11617.
2. Arulanandam, A. R. N., A. Kister, M. J. McGregor, D. F. Wyss, G. Wagner, and E. L. Reinherz. 1994. Interaction between human CD2 and CD58 involves the major β sheet surface of each of their respective adhesion domains. J. Exp. Med. 180:1861-1871.
3. Bodian, D. L., E. Y. Jones, K. Harlos, D. I. Stuart, and S. J. Davis. 1994. Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 Å resolution. Structure. 2:755-766.
4. Bork, P., L. Holm, and C. Sander. 1994. The immunoglobulin fold. J. Mol. Biol. 242:309-320.
5. Carl, P., C. H. Kwok, G. Manderson, D. W. Speicher, and D. E. Discher. 2001. Forced unfolding modulated by disulfide bonds in the Ig domains of a cell adhesion molecule. Proc. Natl. Acad. Sci. USA. 98:1565-1570.
6. Chilkoti, A., T. Boland, B. D. Ratner, and P. S. Stayton. 1995. The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy. Biophys. J. 69:2125-2130.
7. Chothia, C., and E. Y. Jones. 1997. The molecular structure of cell adhesion molecules. Annu. Rev. Biochem. 66:823-862.
8. Davis, S. J., S. Ikemizu, M. K. Wild, and P. A. van der Merwe. 1998a. CD2 and the nature of protein interactions mediating cell-cell recognition. Immunol. Rev. 163:217-236.
9. Davis, S. J., E. A. Davies, M. G. Tucknott, E. Y. Jones, and P. A. van der Merwe. 1998b. The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2. Proc. Natl. Acad. Sci. USA. 95:5490-5494.
10. Evans, E., and K. Ritchie. 1997. Dynamic strength of molecular adhesion bonds. Biophys. J. 72:1541-1555.
11. Evans, E. 1998. Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamic force spectroscopy. Faraday Discuss. 111:1-16.
12. Fisher, T. E., M. Carrion-Vazquez, A. F. Oberhauser, H. Li, P. E. Marszalek, and J. M. Fernandez. 2000. Single molecule force spectroscopy of modular proteins in the nervous system. Neuron. 27:435-446.
13. Humphrey, W., A. Dalke, and K. Schulten. 1996. VMD - visual molecular dynamics. J. Mol. Graph. 14:33-38.
14. Ikemizu, S., L. M. Sparks, P. A. van der Merwe, K. Harlos, D. I. Stuart, E. Y. Jones, and S. J. Davis. 1999. Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8 Å. Proc. Natl. Acad. Sci. USA. 96:4289-4294.
15. Isralewitz, B., M. Gao, and K. Schulten. 2001. Steered molecular dynamics and mechanical functions of proteins. Curr. Opin. Struct. Biol. 11:224-230.
16. Izrailev, S., S. Stepaniants, M. Balsera, Y. Oono, and K. Schulten. 1997. Molecular dynamics study of unbinding of the Aviding-biotin complex. Biophys. J. 72:1568-1581.
17. Kale, L. V., R. D. Skeel, M. Bhandarkar, R. Brunner, A. Gursey, N. Krawetz, J. Philips, A. Shinazaki, K. Varadarajan, and K. Schulten. 1999. NAMD2: greater scalability for parallel molecular dynamics. J. Comp. Phys. 151:283-312.
18. Kim, M., Z. J. Sun, O. Byron, G. Campbell, G. Wagner, J. Wang, and E. L. Reinherz. 2001. Molecular dissection of the CD2-CD58 counter-receptor interface. J. Mol. Biol. 312:711-720.
19. Koyasu, S., T. Lawton, D. Novick, M. A. Recny, R. F. Siliciano, B. P. Wallner, and E. L. Reinherz. 1990. Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen. Proc. Natl. Acad. Sci. USA. 87:2603-2607.
20. Krammer, A., H. Liu, B. Isralewitz, V. Vogel, and K. Schulten. 1999. Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch. Proc. Natl. Acad. Sci. USA. 96:1351-1356.
21. Lu, H., B. Isralewitz, A. Krammer, V. Vogel, and K. Schulten. 1998. Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation. Biophys. J. 75:662-671.
22. MacKerell, A. D., D. Bashford, M. Bellot, R. L. Dunbrack, Jr., J. Evansec, M. J. Field, S. Fisher, J. Gao, H. Guo, S. Ha, D. Joseph, L. Kuchnir, K. Kuczera, F. T. K. Lau, C. Mattos, S. Michnick, T. Ngo, D. T. Nguyen, B. Prodhom, I. W. E. Reiher, B. Roux, M. Schlenkrich, J. Smith, R. Stote, J. Straub, M. Watanabe, J. Wiorkiewicz-Kuczera, D. Yin, and M. Karplus. 1998. All-hydrogen empirical potential for molecular modeling and dynamics studies of proteins using the CHARMM22 force field. J. Phys. Chem. B. 102:3586-3616.
23. Marszalek. P. E., H. Lu, H. B. Li, M. Carrion-Vazquez, A. F. Oberhauser, K. Schulten, and J. M. Fernandez. 1999. Mechanical unfolding intermediates in titin modules. Nature. 402:100-103.
24. Moigneon, P., H. Chang, B. P. Wallner, C. Stebbins, A. Z. Frey, and E. L. Reinherz. 1989. CD2-mediated adhesion facilitates T lymphocyte antigen recognition function. Nature (Lond.). 339:312-314.
25. Wang, J., A. Smolyar, K. Tan, J. Liu, M. Kim, Z. J. Sun, G. Wagner. and E. L. Reinherz. 1999. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell. 97:791-803.
26. Zhu, B., E. A. Davies, P. A. van der Merwe, T. Calvert, and D. E. Leckband. 2002. Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48. Biochemistry. 41:12163-12170.