An actinic keratosis is neither malignant nor premalignant: It is an initiated tumor [4]

Journal of the American Academy of Dermatology

Volumn 48, Issue 4, 2003, Pages 637-638

  Person, John R ^a  

^a Fallon Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINIC KERATOSIS; CANCER CELL; CANCER SUSCEPTIBILITY; GENE MUTATION; HISTOPATHOLOGY; HUMAN; KERATINOCYTE; LETTER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN BIOPSY; TUMOR GROWTH;

EID: 0037380336     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1067/mjd.2003.14     Document Type: Letter

References (11)

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3. Morris RJ, Fischer SM, Sloga TJ. Evidence that a slowly-cycling subpopulation of murine epidermal cells retains carcinogen. Cancer Res 1986;46:3061-6.
4. Mitchell DL, Volkmer B, Breitbart EM. Identification of a non-dividing subpopulation of mouse and human epidermal cells exhibiting high levels of persistent ultraviolet photodamage. J Invest Dermatol 2001;11:590-5.
5. Taylor G, Lehrer MS, Jersen PJ, et al. Involvement of follicular stem cells informing not only the follicle but also the epidermis. Cell 2000;102:451-61.
6. Elder D, Elenitas R, Jaworsky C, Johnson B. Lever's histopathology of the skin. 8th ed. Philadelphia: Lippincott-Raven; 1997, p. 703.
7. Ziegler A, Jonason AS, Leffell DJ, et al. Sunburn and P53 in the onset of skin cancer. Nature 1994;372:773-6.
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10. Nomura T, Nakijima H, Hungyo T, et al. Induction if cancer, actinic keratoses, and specific P53 mutations by UVB light in severe combined immunodeficient mice. Cancer Res 1997;57:2081-4.
11. Atillasoy ES, Elenitsas R, Santer ER, et al. UVB induction of epithelial tumors in human skin using a RAG-1 mouse xenograft model. J Invest Dermatol 1997;109:704-9.