Neuroprotective effects of GYKI 52466 on experimental spinal cord injury in rats

Journal of Neurosurgery

Volumn 98, Issue 3 SUPPL., 2003, Pages 275-281

  Çolak, Ahmet ^a   Soy, Osman ^b   Uzun, Hafize ^b   Aslan, Özcan ^b   Barut, Seref ^b   Belce, Ahmet ^b   Akyildiz, Ayşenur ^b   Taşyürekli, Mustafa ^b  

^a Kartaltepe Mahallesi Incirli Caddesi   (Turkey)

^b NONE

Author keywords

2,3 Benzodiazepine; GYKI 52466; Kainate receptor; Spinal cord injury; amino 3 hydroxy 5 methylisoxazole 4 proprionic acid receptor

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; ADENOSINE TRIPHOSPHATE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; MALONALDEHYDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIPID PEROXIDATION; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0037379835     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2003.98.3.0275     Document Type: Article

References (28)

1. Adams H: Adenosine 5′-triphosphate determination with phosphoglycerate kinase, in Bergmeyer HV, Grabl M, Walter H (eds): Methods of Enzymatic Analysis. New York: Academic Press, 1963, pp 539-543
2. Agrawal SK, Fehlings MG: Mechanisms of secondary injury to spinal cord axons in vitro: role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and Na(+)-Ca2+ exchanger. J Neurosci 16:545-552, 1996
3. Agrawal SK, Fehlings MG: Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 17:1055-1063, 1997
4. Allen AR: Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column: a preliminary report. JAMA 57:877-880, 1911
5. Amar AP, Levy ML: Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery 44:1027-1040, 1999
6. Chimirri A, Gitto R, Zappalà M: AMPA receptor antagonists. Exp Op Ther Patents 9:557-570, 1999
7. Choi DW, Koh JY, Peters S: Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci 8:185-196, 1988
8. Coyle JT: Neurotoxic activation of kainic acid. J Neurochem 41:1-11, 1983
9. Danielisova V, Chavko M, Kehr J: Adenine nucleotide levels and regional distribution of ATP in rabbit spinal cord after ischemia and recirculation. Neurochem Res 12:241-245, 1987
10. De Sarro G, Chimirri A, De Sarro A, et al: GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice. Eu J Pharmacol 294:411-422, 1995
11. Donevan SD, Rogawski MA: GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron 10:51-59, 1993
12. Faden AI, Ellison JA, Noble LJ: Effects of competitive and noncompetitive NMDA receptor antagonists in spinal cord injury. Euro J Pharmacol 175:165-174, 1990
13. Farkas S, Ono H: Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rat: an in vivo study. Bri J Pharmacol 114:1193-1205, 1995
14. Gilbertson TA, Scobey R, Wilson M: Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells. Science 251:1613-1615, 1991
15. Hall ED, Braughler M: Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na+-K+)-ATPase activity. Dose-response analysis during the 1st hour after contusion injury in the cat. J Neurosurg 57:247-253, 1982
16. Iino M, Ozawa S, Tsuzuki K: Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurons. J Physiol 424:151-165, 1990
17. Kriegler S, Chiu JY: Calcium signaling of glial cells along mammalian axons. J Neurosci 13:4229-4245, 1993
18. Rivlin AS, Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:39-43, 1978
19. Rogawski MA: Therapeutic potential of excitatory amino acid antagonists: channel blocker and 2,3-benzodiazepines. Trends Pharmacol Sci 14:325-331, 1993
20. Rothman SM, Olney JW: Glutamate and pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19:105-111, 1986
21. Salter MW, Hicks JL: ATP-evoked increases in intracellular calcium in neurons and glia from the dorsal spinal cord. J Neurosci 14:1563-1575, 1994
22. Smith SE, Durmuller N, Meldrum BS: The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX, are anticonvulsant in two animal models of reflex epilepsy. Eur J Pharmacol 201:179-183, 1991
23. Smith SE, Meldrum BS: Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat. Stroke 23:861-864, 1992
24. Stys RK, Waxman RG, Ramson BR: Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and the Na(+)-Ca2+ exchanger. J Neurosci 12:430-439, 1992
25. Tarlov IM: Spinal Cord Compression: Mechanism of Paralysis and Treatment. Springfield IL: Charles C Thomas, 1957
26. Tamawa I, Farkas S, Berzsenyi P, et al: Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466. Eur J Pharmacol 167:193-199, 1989
27. Uchiama M, Mihara S: Determination of malondialdehyde precursor in tissue by thiobarbituric acid test. Anal Biochem 86:271-278, 1978
28. Vizi ES, Tarnawa I: 2,3-Benzodiazepines (GYKI 52466 and analogues): negative allosteric modulators of AMPA receptor. CNS Drugs Rev 2:91-126, 1996