Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis

Infection and Immunity

Volumn 68, Issue 6, 2000, Pages 3674-3679

  Turner, Oliver C ^a   Roberts, Alan D ^a   Frank, Anthony A ^a   Phalen, Susan W ^b   McMurray, David M ^b   Content, Jean ^c   Denis, Olivier ^c   D'Souza, Sushila ^c   Tanghe, Audrey ^c   Huygen, Kris ^c   Orme, Ian M ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c PASTEUR INSTITUTE OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 60;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM CULTURE; BRONCHIOLITIS; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; GUINEA PIG; IMMUNIZATION; IMMUNOGENICITY; LYMPHOCYTIC INFILTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN PURIFICATION; VACCINATION;

ANIMALS; BCG VACCINE; BRONCHIOLITIS; CHAPERONIN 60; GUINEA PIGS; LUNG; MICE; MYCOBACTERIUM TUBERCULOSIS; NECROSIS; PNEUMONIA, BACTERIAL; TUBERCULOSIS, PULMONARY; VACCINATION; VACCINES, DNA;

EID: 0034091119     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.6.3674-3679.2000     Document Type: Article

References (28)

1. Baldwin, S. L., C. D'Souza, A. D. Roberts, B. P. Kelly, A. A. Frank, M. A. Lui, J. B. Ulmer, K. Huygen, D. M. McMurray, and I. M. Orme. 1998. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect. Immun. 66:2951-2959.
2. Bonato, V. L., V. M. Lima, R. E. Tascon, D. B. Lowrie, and C. L. Silva. 1998. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect. Immun. 66:169-175.
3. Brooks, J. V., S. K. Furney, and I. M. Orme. 1999. Metronidazole therapy in mice infected with tuberculosis. Antimicrob. Agents Chemother. 43:1285-1288.
4. De Bruyn, J., R. Bosmans, M. Turneer, M. Weckx, J. Nyabenda, J. P. Van Vooren, P. Falmagne, H. G. Wiker, and M. Harboe. 1987. Purification, partial characterization, and identification of a skin-reactive protein antigen of Mycobacterium bovis BCG. Infect. Immun. 55:245-252.
5. De Bruyn, J., K. Huygen, R. Bosmans, M. Fauville, R. Lippens, J. P. Van Vooren, P. Falmagne, M. Weckx, H. G. Wiker, M. Harboe, et al. 1987. Purification, characterization and identification of a 32 kDa protein antigen of Mycobacterium bovis BCG. Microb. Pathog. 2:351-366.
6. Horwitz, M. A., B. W. Lee, B. J. Dillon, and G. Harth. 1995. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 92:1530-1534.
7. Huygen, K. 1998. DNA vaccines: application to tuberculosis. Int. J. Tuberc. Lung Dis. 2:971-978.
8. Huygen, K., D. Abramowicz, P. Vandenbussche, F. Jacobs, J. De Bruyn, A. Kentos, A. Drowart, J. P. Van Vooren, and M. Goldman. 1992. Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice. Infect. Immun. 60:2880-2886.
9. Huygen, K., J. Content, O. Denis, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. DeWitt, I. M. Orme, S. Baldwin, C. D'Souza, A. Drowart, E. Lozes, P. Vandenbussche, J. P. Van Vooren, M. A. Liu, and J. B. Ulmer. 1996. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2:893-898.
10. Kamath, A. T., C. G. Feng, M. Macdonald, H. Briscoe, and W. J. Britton. 1999. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect. Immun. 67:1702-1707.
11. Lamb, J. R., V. Bal, P. Mendez-Samperio, A. Mehlert, A. So, J. Rothbard, S. Jindal, R. A. Young, and D. B. Young. 1989. Stress proteins may provide a link between the immune response to infection and autoimmunity. Int. Immunol. 1:191-196.
12. Lamb, J. R., V. Bal, J. B. Rothbard, A. Mehlert, P. Mendez-Samperio, and D. B. Young. 1989. The mycobacterial GroEL stress protein: a common target of T-cell recognition in infection and autoimmunity. J. Autoimmun. 2(Suppl):93-100.
13. Lowrie, D. B., C. L. Silva, M. J. Colston, S. Ragno, and R. E. Tascon. 1997. Protection against tuberculosis by a plasmid DNA vaccine. Vaccine 15:834-838.
14. Lowrie, D. B., R. E. Tascon, V. L. Bonato, V. M. Lima, L. H. Faccioli, E. Stavropoulos, M. J. Colston, R. G. Hewinson, K. Moelling, and C. L. Silva. 1999. Therapy of tuberculosis in mice by DNA vaccination. Nature 400:269-271.
15. Orme, I. M. 1999. New vaccines against tuberculosis. The status of current research. Infect. Dis. Clin. N. Am. 13:169-185, vii-viii.
16. Pal, P. G., and M. A. Horwitz. 1992. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infect. Immun. 60:4781-4792.
17. Scanga, C. A., V. P. Mohan, H. Joseph, K. Yu, J. Chan, and J. L. Flynn. 1999. Reactivation of latent tuberculosis: variations on the Cornell murine model. Infect. Immun. 67:4531-4538.
18. Shinnick, T. M. 1987. The 65-kilodalton antigen of Mycobacterium tuberculosis. J. Bacteriol. 169:1080-1088.
19. Shinnick, T. M., D. Sweetser, J. Thole, J. van Embden, and R. A. Young. 1987. The etiologic agents of leprosy and tuberculosis share an immunoreactive protein antigen with the vaccine strain Mycobacterium bovis BCG. Infect. Immun. 55:1932-1935.
20. Shinnick, T. M., M. H. Vodkin, and J. C. Williams. 1988. The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein. Infect. Immun. 56:446-451.
21. Sonnenberg, M. G., and J. T. Belisle. 1997. Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electrospray mass spectrometry. Infect. Immun. 65:4515-4524.
22. Tanghe, A., P. Lefevre, O. Denis, S. D'Souza, M. Braibant, E. Lozes, M. Singh, D. Montgomery, J. Content, and K. Huygen. 1999. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J. Immunol. 162:1113-1119.
23. Tascon, R. E., M. J. Colston, S. Ragno, E. Stavropoulos, D. Gregory, and D. B. Lowrie. 1996. Vaccination against tuberculosis by DNA injection. Nat. Med. 2:888-892.
24. Turner, J., E. R. Rhoades, M. Keen, J. T. Belisle, A. A. Frank, and I. M. Orme. 2000. Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode. Infect. Immun. 68:1706-1709.
25. Young, D. B. 1990. Chaperonins and the immune response. Semin. Cell Biol. 1:27-35.
26. Young, D. B. 1990. The immune response to mycobacterial heat shock proteins. Autoimmunity 7:237-244.
27. Young, D. B. 1990. Stress proteins and the immune response. Antonie Leeuwenhoek 58:203-208.
28. Zhu, X., N. Venkataprasad, H. S. Thangaraj, M. Hill, M. Singh, J. Ivanyi, and H. M. Vordermeier. 1997. Functions and specificity of T cells following nucleic acid vaccination of mice against Mycohacterium tuberculosis infection. J. Immunol. 158:5921-5926.