Isoflurane action in spinal cord indirectly depresses cortical activity associated with electrical stimulation of the reticular formation

Anesthesia and Analgesia

Volumn 96, Issue 4, 2003, Pages 999-1003

  Antognini, Joseph F ^a   Atherley, Richard ^a   Carstens, Earl ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INHALATION ANESTHETIC AGENT; ISOFLURANE;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; ELECTROENCEPHALOGRAM; ELECTROSTIMULATION; FEMALE; GOAT; INHALATION ANESTHESIA; MESENCEPHALON; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RETICULAR FORMATION; SPINAL CORD;

ANESTHETICS, INHALATION; ANIMALS; BRAIN; CEREBRAL CORTEX; DEPRESSION, CHEMICAL; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; FEMALE; GOATS; ISOFLURANE; RETICULAR FORMATION; SPINAL CORD; STEREOTAXIC TECHNIQUES; SYNAPTIC TRANSMISSION;

EID: 0037377948     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Antognini JF, Schwartz K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology 1993;79: 1244-9.
2. Rampil IJ. Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology 1994;80:606-10.
3. Antognini JF, Carstens E, Atherley R. Does the immobilizing effect of thiopental in brain exceed that of halothane? Anesthesiology 2002;96:980-6.
4. Kendig JJ. Spinal cord as a site of anesthetic action. Anesthesiology 1993;79:1161-2.
5. Ben-David B, Vaida S, Gaitini L. The influence of high spinal anesthesia on sensitivity to midazolam sedation. Anesth Analg 1995;81:525-8.
6. Eappen S, Kissin I. Effect of subarachnoid bupivacaine block on anesthetic requirements for thiopental in rats. Anesthesiology 1998;88:1036-42.
7. Antognini JF, Carstens E, Sudo M, Sudo S. Isoflurane depresses electroencephalographic and medial thalamic responses to noxious stimulation via an indirect spinal action. Anesth Analg 2000;91:1282-8.
8. Antognini JF, Wang XW, Carstens E. Isoflurane action in the spinal cord blunts electroencephalographic and thalamicreticular formation responses to noxious stimulation in goats. Anesthesiology 2000;92:559-66.
9. Steriade M. Arousal: revisiting the reticular activating system. Science 1996;272:225-6.
10. Moruzzi G, Magoun HW. Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1949;1:455-73.
11. Antognini JF, Jinks S, Buzin V, Carstens E. A method for differential delivery of intravenous drugs to the head and torso of the goat. Anesth Analg 1998;87:1450-2.
12. Antognini JF, Kien ND. A method for preferential delivery of volatile anesthetics to the in situ goat brain. Anesthesiology 1994;80:1148-54.
13. Pollock JE, Neal JM, Liu SS, et al. Sedation during spinal anesthesia. Anesthesiology 2000;93:728-34.
14. Hodgson PS, Liu SS. Epidural lidocaine decreases sevoflurane requirement for adequate depth of anesthesia as measured by the Bispectral Index monitor. Anesthesiology 2001;94:799-803.
15. Antognini JF, Wang XW, Carstens E. Isoflurane anaesthetic depth in goats monitored using the bispectral index of the electroencephalogram. Vet Res Commun 2000;24:361-70.
16. Millan MJ. Descending control of pain. Prog Neurobiol 2002;66:355-474.
17. Lima D, Almeida A. The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system. Prog Neurobiol 2002;66:81-108.
18. Peng YB, Lin Q, Willis WD. The role of 5-HT3 receptors in periaqueductal gray-induced inhibition of nociceptive dorsal horn neurons in rats. J Pharmacol Exp Ther 1996;276:116-24.
19. Gerhart 0KD, Yezierski RP, Wilcox TK, Willis WD. Inhibition of primate spinothalamic tract neurons by stimulation in periaqueductal gray or adjacent midbrain reticular formation. J Neurophysiol 1984;51:450-66.
20. Carstens E, Bihl H, Irvine DR, Zimmermann M. Descending inhibition from medial and lateral midbrain of spinal dorsal horn neuronal responses to noxious and nonnoxious cutaneous stimuli in the cat. J Neurophysiol 1981;45:1029-42.
21. Carstens E, Douglass DK. Midbrain suppression of limb withdrawal and tail flick reflexes in the rat: correlates with descending inhibition of sacral spinal neurons. J Neurophysiol 1995;73:2179-94.
22. Steraide M, Demetrescu M. Unspecific systems of facilitation and inhibition and facilitation of potentials evoked by intermittent light. J Neurophysiol 1960;23:602-17.
23. Munk MH, Roelfsema PR, Konig P, et al. Role of reticular activation in the modulation of intracortical synchronization. Science 1996;272:271-4.