Amelioration of ischemia-reperfusion injury with cyclic peptide blockade of ICAM-1

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 284, Issue 4 53-4, 2003, Pages

  Merchant, Shakil H ^a   Gurule, Debbie M ^a   Larson, Richard S ^a,b  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Cell adhesion; Infarction; Peptide antagonist

Indexed keywords

CYSTEINYLLEUCYLLEUCYLARGINYLMETHIONYLLYSYLSERYLALANYLCYSTEINE; INTERCELLULAR ADHESION MOLECULE 1; IP 25; NONAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; DISEASE MODEL; FEMALE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; LEG; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; TOURNIQUET;

EID: 0037377555     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00840.2002     Document Type: Article

References (55)

1. Altavilla D, Squadrito F, Ioculano M, Canale P, Campo GM, Zingarelli B, and Caputi AP. E-selectin in the pathogenesis of experimental myocardial ischemia-reperfusion injury. Eur J Pharmacol 270: 45-51, 1994.
2. Amsterdam EA, Stahl GL, Pan HL, Rendig SV, Fletcher MP, and Longhurst JC. Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs. Am J Physiol Heart Circ Physiol 268: H448-H457, 1995.
3. Briaud SA, Ding ZM, Michael LH, Entman ML, Daniel S, and Ballantyne CM. Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice. Am J Physiol Heart Circ Physiol 280: H60-H67, 2001.
4. Burks EJ, Sillerud LO, Wester MJ, Brown DC, and Larson RS. ICAM-1 inhibitory peptides: identification and structure of potent derivatives. Biochemistry. In press.
5. Casasnovas JM, Pieroni C, and Springer TA. Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. Proc Natl Acad Sci USA 96: 3017-3022, 1999.
6. Chatelain P, Latour JG, Tran D, de Lorgeril M, Dupras G, and Bourassa M. Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion. Circulation 75: 1083-1090, 1987.
7. Dreyer WJ, Michael LH, West MS, Smith CW, Rothlein R, Rossen RD, Anderson DC, and Entman ML. Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion. Circulation 84: 400-411, 1991.
8. Dreyer WJ, Smith CW, Michael LH, Rossen RD, Hughes BJ, Entman ML, and Anderson DC. Canine neutrophil activation by cardiac lymph obtained during reperfusion of ischemic myocardium. Circ Res 65: 1751-1762, 1989.
9. Engler RL, Dahlgren MD, Peterson MA, Dobbs A, and Schmid-Schonbein GW. Accumulation of polymorphonuclear leukocytes during 3-h experimental myocardial ischemia. Am J Physiol Heart Circ Physiol 251: H93-H100, 1986.
10. Faxon DP, Gibbons RJ, Chronos NAF, Gurbal PA, and Martin JS. The effect of CD11/CD18 inhibitor (HU23F2G) on infarct size following direct angioplasty: The Halt MI Study. Circulation 100: 4180, 2000.
11. Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, and Ward PA. C5a-induced expression of P-selectin in endothelial cells. J Clin Invest 94: 1147-1155, 1994.
12. Ginis I, Mentzer SJ, and Faller DV. Oxygen tension regulates neutrophil adhesion to human endothelial cells via an LFA-1-dependent mechanism. J Cell Physiol 157: 569-578, 1993.
13. Genetech. Press release: Genetech announces phase II trial of experimental anti-CD18 antibody did not meet its primary objectives. 2000. http://www.gene.coni/gene/news/press-releases/detail. jsp?detail = 4623&pNo = 1&search= 1&keyword= Anti-CD18 + antibody&begindatemonth = January&begindateyear= 2000&enddatemonth=December&enddateyear=2000.
14. Goligorsky MS, Noiri E, Kessler H, and Romanov V. Therapeutic effect of arginine-glycine-aspartic acid peptides in acute renal injury. Clin Exp Pharmacol Physiol 25: 276-279, 1998.
15. Grace PA. Ischaemia-reperfusion injury. Br J Surg 81: 637-647, 1994.
16. Harnarayan C, Bennett MA, Pentecost BL, and Brewer DB. Quantitative study of infarcted myocardium in cardiogenic shock. Br Heart J 32: 728-732, 1970.
17. Hartman JC, Anderson DC, Wiltse AL, Lane CL, Rosenbloom CL, Manning AM, Humphrey WR, Wall TM, and Shebuski RJ. Protection of ischemic/reperfused canine myocardium by CL18/6, a monoclonal antibody to adhesion molecule ICAM-1. Cardiovasc Res 30: 47-54, 1995.
18. Iwata A, Harlan JM, Vedder NB, and Winn RK. The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials. Blood 100: 2077-2080, 2002.
19. Jackson DY, Quan C, Artis DR, Rawson T, Blackburn B, Struble M, Fitzgerald G, Chan K, Mullins S, Burnier JP, Fairbrother WJ, Clark K, Berisini M, Chui H, Renz M, Jones S, and Fong S. Potent alpha4beta1 peptide antagonists as potential anti-inflammatory agents. J Med Chem 40: 3359-3368, 1997.
20. Jean WC, Spellman SR, Nussbaum ES, and Low WC. Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery 43: 1382-1396, 1998.
21. Jolly SR, Kane WJ, Hook BG, Abrams GD, Kunkel SL, and Lucchesi BR. Reduction of myocardial infarct size by neutrophil depletion: effect of duration of occlusion. Am Heart J 112: 682-690, 1986.
22. King RC, Binns OA, Rodriguez F, Kanithanon RC, Daniel TM, Spotnitz WD, Tribble CG, and Kron IL. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg 69: 1681-1685, 2000.
23. Kishimoto TK, Jutila MA, Berg EL, and Butcher EC. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238-1241, 1989.
24. Kukielka GL, Hawkins HK, Michael L, Manning AM, Youker K, Lane C, Entman ML, Smith CW, and Anderson DC. Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium. J Clin Invest 92: 1504-1516, 1993.
25. Lefer AM. Role of selectins in myocardial ischemia-reperfusion injury. Ann Thorac Surg 60: 773-777, 1995.
26. Lefer AM. Role of the beta2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion. Ann Thorac Surg 68: 1920-1923, 1999.
27. Lefkovits J and Topol EJ. Platelet glycoprotein IIb/IIIa receptor inhibitors in ischemic heart disease. Curr Opin Cardiol 10: 420-426, 1995.
28. Ma XL, Lefer DJ, Lefer AM, and Rothlein R. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 86: 937-946, 1992.
29. Ma XL, Tsao PS, and Lefer AM. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J Clin Invest 88: 1237-1243, 1991.
30. Metzler B, Mair J, Lercher A, Schaber C, Hintringer F, Pachinger O, and Xu Q. Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1. Cardiovasc Res 49: 399-407, 2001.
31. Mullane KM, Read N, Salmon JA, and Moncada S. Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther 228: 510-522, 1984.
32. Noiri E, Gailit J, Sheth D, Magazine H, Gurrath M, Muller G, Kessler H, and Goligorsky MS. Cyclic RGD peptides ameliorate ischemic acute renal failure in rats. Kidney Int 46: 1050-1058, 1994.
33. Nolte D, Hecht R, Schmid P, Botzlar A, Menger MD, Neumueller C, Sinowatz F, Vestweber D, and Messmer K. Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice. Am J Physiol Heart Circ Physiol 267: H1320-H1328, 1994.
34. Palazzo AJ, Jones SP, Girod WG, Anderson DC, Granger DN, and Lefer DJ. Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice. Am J Physiol Heart Circ Physiol 275: H2300-H2307, 1998.
35. Pemberton M, Anderson G, Vetvicka V, Justus DE, and Ross GD. Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle. J Immunol 150: 5104-5113, 1993.
36. Perez RG, Arai M, Richardson C, DiPaula A, Siu C, Matsumoto N, Hildreth JE, Mariscalco MM, Smith CW, and Becker LC. Factors modifying protective effect of anti-CD18 antibodies on myocardial reperfusion injury in dogs. Am J Physiol Heart Circ Physiol 270: H53-H64, 1996.
37. Pfeffer MA and Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 81: 1161-1172, 1990.
38. Rectenwald JE, Huber TS, Martin TD, Ozaki CK, Devidas M, Welborn MB, and Seeger JM. Functional outcome after thoracoabdominal aortic aneurysm repair. J Vasc Surg 35: 640-647, 2002.
39. Rhee P, Morris J, Durham R, Hauser C, Cipolle M, Wilson R, Luchette F, McSwain N, and Miller R. Recombinant humanized monoclonal antibody against CD18 (rhuMAb CD18) in traumatic hemorrhagic shock: results of a phase II clinical trial. Traumatic Shock Group. J Trauma 49: 611-619, 2000.
40. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, and Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 67: 1016-1023, 1983.
41. Rossen RD, Swain JL, Michael LH, Weakley S, Giannini E, and Entman ML. Selective accumulation of the first component of complement and leukocytes in ischemic canine heart muscle. A possible initiator of an extra myocardial mechanism of ischemic injury. Circ Res 57: 119-130, 1985.
42. Schmid-Schonbein GW and Engler RL. Granulocytes as active participants in acute myocardial ischemia and infarction. Am J Cardiovasc Pathol 1: 15-30, 1987.
43. Serracino-Inglott F, Habib NA, and Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg 181: 160-166, 2001.
44. Shannon JP, Silva MV, Brown DC, and Larson RS. Novel cyclic peptide inhibits intercellular adhesion molecule-1-mediated cell aggregation. J Pept Res 58: 140-150, 2001.
45. Sholter DE and Armstrong PW. Adverse effects of corticosteroids on the cardiovascular system. Can J Cardiol 16: 505-511, 2000.
46. Simms MG and Walley KR. Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1-dependent adhesion. Am J Physiol Heart Circ Physiol 277: H253-H260, 1999.
47. Sommers HM and Jennings RB. Experimental acute myocardial infarction. Histologic and histochemical studies of early myocardial infarcts induced by temporary or permanent occlusion of a coronary artery. Lab Invest 13: 1491-1503, 1964.
48. Staunton DE, Dustin ML, Erickson HP, and Springer TA. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 61: 243-254, 1990.
49. Tamiya Y, Yamamoto N, and Uede T. Protective effect of monoclonal antibodies against LFA-1 and ICAM-1 on myocardial reperfusion injury following global ischemia in rat hearts. Immunopharmacology 29: 53-63, 1995.
50. Tanaka M, Brooks SE, Richard VJ, FitzHarris GP, Stoler RC, Jennings RB, Arfors KE, and Reimer KA. Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 87:526-535, 1993.
51. Vedder NB, Harlan JM, and Winn RK. Immunomodulators: inhibitors of adhesion. Shock 13: 1, 2000.
52. Vuorte J, Lindsberg PJ, Kaste M, Meri S, Jansson SE, Rothlein R, and Repo H. Anti-ICAM-1 monoclonal antibody R6.5 (Enlimomab) promotes activation of neutrophils in whole blood. J Immunol 162: 2353-2357, 1999.
53. Youker KA, Hawkins HK, Kukielka GL, Perrard JL, Michael LH, Ballantyne CM, Smith CW, and Entman ML. Molecular evidence for induction of intracellular adhesion molecule-1 in the viable border zone associated with ischemiareperfusion injury of the dog heart. Circulation 89: 2736-2746, 1994.
54. Zhao ZQ, Lefer DJ, Sato H, Hart KK, Jefforda PR, and Vinten-Johansen J. Monoclonal antibody to ICAM-1 preserves postischemic blood flow and reduces infarct size after ischemia-reperfusion in rabbit. J Leukoc Biol 62: 292-300, 1997.
55. Zund G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE, and Colgan SP. Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci USA 93: 7075-7080, 1996.