Disseminated tumor cells in bone marrow of patients with transitional cell carcinoma: Immunocytochemical detection and correlation with established prognostic indicators

Journal of Urology

Volumn 169, Issue 4, 2003, Pages 1303-1307

  Hofmann, Thomas ^a   Riesenberg, Rainer ^a   Buchner, Alexander ^a   Zimmermann, Wolfgang ^a   Hofstetter, Alfons ^a   Oberneder, Ralph ^a  

^a NONE

Author keywords

Bladder; Bone marrow; Carcinoma; Immunohistochemistry; Transitional cell

Indexed keywords

CYTOKERATIN; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; BLADDER CARCINOMA; BONE MARROW BIOPSY; BONE MARROW CELL; BONE MARROW METASTASIS; CANCER GRADING; CANCER RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INCUBATION TIME; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; TRANSITIONAL CELL CARCINOMA; TUMOR GROWTH;

EID: 0037377252     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000054917.31718.cd     Document Type: Article

References (20)

1. Sloane, J. P., Ormerod, M. G. and Neville, A. M.: Potential pathological application of immunocytochemical methods to the detection of micrometastases. Cancer Res, 40: 3079, 1980
2. Funke, I. and Schraut, W.: Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. J Clin Oncol, 16: 557, 1998
3. Pantel, K., Izbicki, J., Passlick, B., Angstwurm, M., Haussinger, K., Thetter, O. et al: Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with nonsmall-cell lung cancer without overt metastases. Lancet, 347: 649, 1996
4. Schlimok, G., Funke, I., Pantel, K., Strobel, F., Lindemann, F., Witte, J. et al: Micrometastatic tumour cells in bone marrow of patients with gastric cancer: methodological aspects of detection and prognostic significance. Eur J Cancer, 27: 1461, 1991
5. Weckermann, D., Müller, P., Wawroschek, F., Harzmann, R., Riethmüller, G. and Schlimok, G.: Disseminated cytokeratin positive tumor cells in the bone marrow of patients with prostate cancer: detection and prognostic value. J Urol, 166: 699, 2001
6. Pantel, K. and Otte, M.: Disseminated tumor cells: diagnosis, prognostic relevance, and phenotyping. Recent Results Cancer Res, 158: 14, 2001
7. Schlimok, G., Funke, I., Holzmann, B., Gottlinger, G., Schmidt, G., Hauser, H. et al: Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies. Proc Natl Acad Sci USA, 84: 8672, 1987
8. Debus, E., Moll, R., Franke, W. W., Weber, K. and Osborn, M.: Immunohistochemical distinction of human carcinomas by cytokeratin typing with monoclonal antibodies. Am J Pathol, 114: 121, 1984
9. Cordell, J. L., Falini, B., Erber, W. N., Ghosh, A. K., Abdulaziz, Z., MacDonald, S. et al: Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem, 32: 219, 1984
10. Li, S., Leißner, J., Steinbach, F., Brenner, W., Bürger, R. A. and Stöckle, M.: Immunzytologische Färbung des Knochenmarks bei Patienten mit scheinbar organbegrenzten Tumoren-Nachweismöglichkeit einer beginnenden Tumordisseminierung? Akt Urol, 6: 96, 1995
11. Pantel, K., Schlimok, G., Angstwurm, M., Weckermann, D., Schmaus, W., Gath, H. et al: Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow. J Hematother, 3: 165, 1994
12. Hijazi, A., Devonec, M., Bouvier, R. and Revillard, J.-P.: Flow cytometric study of cytokeratin 18 expression according to tumor grade and deoxyribonucleic acid content in human bladder tumors. J Urol, 141: 522, 1989
13. Wood, D. P., Jr., Banks, E. R., Humpreys, S. and Rangekar, V. M.: Sensitivity of immunochemistry and polymerase chain reaction in detecting prostate cancer cells in bone marrow. J Histochem Cytochem, 42: 505, 1994
14. Desgrandchamps, F., Teren, M., Dal Cortivo, L., Marolleau, J. P., Bertheau, P., Villette, J. M. et al: The effects of transurethral resection and cystoprostatectomy on dissemination of epithelial cells in circulation of patients with bladder cancer. Br J Cancer, 81: 832, 1999
15. Zippelius, A., Kufer, P., Honold, G., Kollermann, M. W., Oberneder, R., Schlimok, G. et al: Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow. J Clin Oncol, 15: 2701, 1997
16. Ruud, P., Fodstad, O. and Hovig, E.: Identification of a novel cytokeratin 19 pseudogene that may interfere with with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells. Int J Cancer, 80: 119, 1999
17. Franke, W. W. and Moll, R.: Cytoskeletal components of lymphoid organs. I. Synthesis of cytokeratins 8 and 18 and desminin subpopulations of extrafollicular reticulum cells of human lymph nodes, tonsils and spleen. Differentiation, 36: 145, 1987
18. Riesenberg, R., Oberneder, R., Kriegmair, M., Epp, M., Bitzer, U., Hofstetter, A. et al: Immunocytochemical double staining of cytokeratin and prostate specific antigen in individual prostatic tumour cells. Histochemistry, 99: 61, 1993
19. Pantel, K., Schlimok, G., Braun, S., Kutter, D., Lindemann, F., Schaller, G. et al: Differential expression of proliferationassociated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst, 85: 1419, 1993
20. Allgayer, H., Heiss, M. M., Riesenberg, R., Gruetzner, K. U., Tarabichi, A., Babic, R. et al: Urokinase plasminogen activator receptor (uPa-R): one potential characteristic of metastatic phenotypes in minimal residual tumor disease. Cancer Res, 57: 1394, 1997