Functional regulation of choline acetyltransferase by phosphorylation

Neurochemical Research

Volumn 28, Issue 3-4, 2003, Pages 537-542

  Dobransky, Tomas ^a   Rylett, R Jane ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Acetylcholine; Choline acetyltransferase; Cholinergic; Phosphorylation; Proteomics

Indexed keywords

ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; SERINE; THREONINE;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CHOLINERGIC NERVE CELL; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SYNTHESIS;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; CHOLINE O-ACETYLTRANSFERASE; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION;

EID: 0037375883     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022873323561     Document Type: Article

References (37)

1. Misawa, H., Ishi, K., and Deguchi, T. 1992. Gene expression of mouse choline acetyltransferase: Alternative splicing and identification of a highly active promoter region. J. Biol. Chem. 267:20392-20399.
2. Oda, Y., Nakanishi, I., and Deguchi, T. 1992. A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells. Mol. Brain Res. 16:287-294.
3. Robert, I. and Quirin-Stricker, C. 2001. A novel untranslated 'exon H' of the human choline acetyltransferase gene in placenta. J. Neurochem. 79:9-16.
4. Misawa, H., Matsuura, J., Oda, Y., Takahashi, R., and Deguchi, T. 1997. Human choline acetyltransferase mRNAs with different 5′-region produce a 69-kD major translation product. Mol. Brain Res. 44:323-333.
5. Ohno, K., Tsujino, A., Brengman, J. M., Harper, C. M., Bajzer, Z., Udd, B., Beyring, R., Robb, S., Kirkham, F. J., and Engel, A. G. 2001. Choline acetyltransferase mutations cause myasthenic syndrome associated with apnea in humans. Proc. Nat. Acad. Sci. 98:2017-2022.
6. Resendes, M. C., Dobransky, T., Ferguson, S. S., and Rylett, R. J. 1999. Nuclear localization of the 82-kD form of human choline acetyltransferase. J. Biol. Chem. 274:19417-19421.
7. Dobransky, T., Davis, W. L., Xiao, G. H., and Rylett, R. J. 2000. Expression, purification and characterization of recombinant human choline acetyltransferase: Phosphorylation of the enzyme regulates catalytic activity. Biochem. J. 349: 141-151.
8. Tuček, S. 1990. The synthesis of acetylcholine: Twenty years of progress. Prog. Brain Res. 84:467-477.
9. Hersh, L. B. 1982. Kinetic studies of the choline acetyltransferase reaction using isotope exchange at equilibrium. J. Biol. Chem. 257:12820-12834.
10. Tuček, S. 1985. Regulation of acetylcholine synthesis in the brain. J. Neurochem. 44:10-24.
11. Uney, J. B. and Marchbanks, R. M. 1987. Specificity of ethylcholine mustard aziridinium as an irreversible inhibitor of choline transport in cholinergic and noncholinergic tissue. J. Neurochem. 48:1673-1676.
12. Pongrac, J. L. and Rylett, R. J. 1996. Differential effects of nerve growth factor on expression of choline acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture. J. Neurochem. 66:804-810.
13. Cooke, L. J. and Rylett, R. J. 1997. Inhibitors of serine/threonine phosphatases increase membrane-bound choline acetyltransferase activity and enhance acetylcholine synthesis. Brain Res. 751:232-238.
14. Rylett, R. J. and Schmidt, B. M. 1993. Regulation of the synthesis of acetylcholine. Prog. Brain Res. 98:161-166.
15. Collier, B., Tandon, A., Prado, M. A. M., and Bachoo, M. 1993. Storage and release of acetylcholine in a sympathetic ganglion. Prog. Brain Res. 98:183-189.
16. Tandon, A., Bachoo, M., Weldon, P., Polosa, C., and Collier, B. 1996. Effects of colchicine application to preganglionic axons on choline acetyltransferase activity and acetylcholine content and release in the superior cervical ganglion. J. Neurochem. 66:1033-1041.
17. Browning, M. D., Huganir, R., and Greengard, P. 1985. Protein phosphorylation and neuronal function. J. Neurochem. 45:11-22.
18. Schenk, P. W. and Snaar-Jagalska, B. E. 1999. Signal perception and transduction: The role of protein kinases. Biochim. Biophys. Acta 1449:1-24.
19. Graves, J. D. and Krebs, E. G. 1999. Protein phosphorylation and signal transduction. Pharmacol. Ther. 82:111-121.
20. Yaffe, M. B. and Cantley, L. C. 1999. Signal transduction: Grabbing phosphoproteins. Nature 402:30-31.
21. Kumer, S. C. and Vrana, K. E. 1996. Intricate regulation of tyrosine hydroxylase activity and gene expression. J. Neurochem. 67:443-462.
22. Schmidt, B. M. and Rylett, R. J. 1993. Phosphorylation of rat brain choline acetyltransferase and its relationship to enzyme activity. J. Neurochem. 61:1774-1781.
23. Bruce, G. and Hersh, L. B. 1989. The phosphorylation of choline acetyltransferase. Neurochem. Res. 14:613-620.
24. Habert, E., Birman, S., and Mallet, J. 1992. High-level synthesis and fate of acetylcholine in baculovirus-infected cells: Characterization and purification of recombinant rat choline acetyltransferase. J. Neurochem. 58:1447-1453.
25. Dobransky, T., Davis, W. L., and Rylett, R. J. 2001. Functional characterization of phosphorylation of 69-kD human choline acetyltransferase at serine-440 by protein kinase C. J. Biol. Chem. 276:22244-22250.
26. Dobransky, T., Brewer, D., Lajoie, G., and Rylett, R. J. 2003. Phosphorylation of 69-kD choline acetyltransferase at threonine-456 in response to short-term exposure to amyloid-β peptide 1-42. J. Biol. Chem. in press.
27. +-, calmodulindependent protein kinase: Purification and characterization. J. Biol. Chem. 256:5404-5409.
28. Ichimura, T., Isobe, T., Okuyama, T., Takahashi, N., Araki, K., Kuwano, R., and Takahashi, Y. 1988. Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. Proc. Nat. Acad. Sci. 85:7084-7088.
29. Cozzari, C. and Hartman, B. K. 1983. Choline acetyltransferase: Purification procedure and factors affecting chromatographic properties and enzyme stability. J. Biol. Chem. 258:10013-10019.
30. Cozzari, C. and Hartman, B. K. 1983. An endogenous inhibitory factor for choline acetyltransferase. Brain Res. 276:109-117.
31. Andriamampandry, C. and Kanfer, J. N. 1993. Inhibition of cytosolic human forebrain choline acetyltransferase activity by phospho-L-serine: A phosphomonoester that accumulates during early stages of Alzheimer's disease. Neurobiol. Aging 14:367-372.
32. Singh, I., Xu, C., Pettegrew, J. W., and Kanfer, J. N. 1994. Endogenous inhibitors of human choline acetyltransferase present in Alzheimer's brain: Preliminary observation. Neurobiol. Aging 15:643-649.
33. Pahud, G., Salem, N., van de Goor, J., Medilanski, J., Pellegrinelli, N., and Eder-Colli, L. 1998. Study of subcellular localization of membrane-bound choline acetyltransferase in Drosophila central nervous system and its association with membranes. Eur. J. Neurosci. 10: 1644-1653.
34. Carroll, P. T., Badamchian, M., Craig, P., and Lyness, W. H. 1986. Veratridine-induced breakdown of cytosolic acetylcholine in rat hippocampal minces: An intraterminal form of acetylcholinesterase or choline O-acetyltransferase? Brain Res. 383:83-99.
35. Carroll, P. T. 1987. Veratridine-induced activation of cholineO-acetyltransferase activity in rat hippocampal tissue: Relationship to the veratridine-induced release of acetylcholine. Brain Res. 414:401-404.
36. Pisano, M. R., Wang, H. Y., and Friedmann, E. 1991. Protein kinase activity changes in the aging brain. Biomed. Environ. Sci. 4:173-171.
37. Clark, E. A., Leach, K. L., Trojanowski, J. Q., and Lee, M. Y. 1991. Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. Lab. Invest. 64:35-44.