Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine

Journal of Pharmaceutical Sciences

Volumn 92, Issue 3, 2003, Pages 485-493

  Kelly, Seán S ^a,c   Glynn, Padraig M ^a   Madden, Stuart J ^a   Grayson, David H ^b  

^a ELAN PHARMACEUTICALS   (United States)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c Merck Sharp and Dohme   (Ireland)

Author keywords

10 hydroxymorphine; 10 oxomorphine; 5 (hydroxymethyl) 2 furfural; Morphine sulfate; Nonpareil sugar seeds

Indexed keywords

10 HYDROXYMORPHINE; 10 OXOMORPHINE; 5 (HYDROXYMETHYL) 2 FURFURAL; FUMARIC ACID; FURFURAL; HEXOSE; ION EXCHANGE RESIN; MORPHINE DERIVATIVE; MORPHINE SULFATE; STARCH; SUCROSE; SUGAR; UNCLASSIFIED DRUG;

ANION EXCHANGE; ARTICLE; DRUG DEGRADATION; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG IMPURITY; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLID PHASE EXTRACTION;

EID: 0037373356     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10330     Document Type: Article

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